Details of the Target

General Information of Target

Target ID LDTP04996
Target Name Protein yippee-like 5 (YPEL5)
Gene Name YPEL5
Gene ID 51646
Synonyms
Protein yippee-like 5
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRV
MLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDN
S
Target Bioclass
Enzyme
Family
Yippee family
Subcellular location
Nucleus
Function
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for normal cell proliferation.
Uniprot ID
P62699
Ensemble ID
ENST00000261353.9
HGNC ID
HGNC:18329

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(0.74)  LDD0812  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C20(0.74)  LDD0812  [1]
 LDCM0216  AC100 HEK-293T C20(1.04)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C20(1.04)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C20(1.08)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C20(1.16)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C20(1.14)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C20(0.79)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C20(0.79)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C20(1.10)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C20(1.49)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C20(1.33)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C20(1.55)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C20(1.89)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C20(2.05)  LDD0827  [1]
 LDCM0276  AC17 HEK-293T C20(1.39)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C20(1.17)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C20(1.38)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C20(0.83)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C20(1.29)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C20(1.17)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C20(1.46)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C20(1.40)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C20(1.07)  LDD0882  [1]
 LDCM0290  AC3 HEK-293T C20(0.87)  LDD0888  [1]
 LDCM0296  AC35 HEK-293T C20(1.15)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C20(1.13)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C20(1.12)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C20(1.31)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C20(1.20)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C20(1.32)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C20(1.05)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C20(1.10)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C20(1.18)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C20(1.44)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C20(1.41)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C20(1.10)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C20(1.13)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C20(0.98)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C20(0.88)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C20(1.23)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C20(1.16)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C20(1.04)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C20(1.18)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C20(1.06)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C20(1.16)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C20(1.27)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C20(1.24)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C20(1.01)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C20(1.39)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C20(1.04)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C20(1.10)  LDD0920  [1]
 LDCM0324  AC60 HEK-293T C20(0.84)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C20(1.26)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C20(0.99)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C20(0.97)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C20(0.99)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C20(1.30)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C20(1.10)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C20(1.36)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C20(1.02)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C20(1.04)  LDD0931  [1]
 LDCM0335  AC70 HEK-293T C20(1.22)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C20(1.10)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C20(1.19)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C20(1.12)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C20(1.38)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C20(1.02)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C20(1.02)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C20(1.21)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C20(1.03)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C20(1.16)  LDD0942  [1]
 LDCM0346  AC80 HEK-293T C20(1.20)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C20(1.14)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C20(1.41)  LDD0946  [1]
 LDCM0365  AC98 HEK-293T C20(1.05)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C20(1.00)  LDD0964  [1]
 LDCM0367  CL1 HEK-293T C20(0.96)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C20(1.74)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C20(0.95)  LDD0967  [1]
 LDCM0374  CL105 HEK-293T C20(1.01)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C20(0.90)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C20(1.26)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C20(1.22)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C20(0.96)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C20(1.21)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C20(1.06)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C20(1.11)  LDD0979  [1]
 LDCM0387  CL117 HEK-293T C20(0.97)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C20(1.06)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C20(1.20)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C20(1.31)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C20(1.15)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C20(1.43)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C20(1.27)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C20(1.01)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C20(1.00)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C20(1.15)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C20(1.07)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C20(0.99)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C20(1.12)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C20(1.36)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C20(1.03)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C20(1.28)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C20(0.80)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C20(0.79)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C20(1.13)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C20(1.00)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C20(0.93)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C20(1.09)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C20(1.01)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C20(1.14)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C20(1.34)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C20(1.15)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C20(1.11)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C20(1.24)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C20(1.22)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C20(1.09)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C20(1.18)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C20(1.05)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C20(1.46)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C20(0.92)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C20(1.25)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C20(1.25)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C20(1.11)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C20(1.18)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C20(1.11)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C20(1.29)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C20(1.91)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C20(1.13)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C20(1.24)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C20(1.63)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C20(1.70)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C20(1.90)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C20(1.33)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C20(1.26)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C20(1.09)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C20(1.05)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C20(0.93)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C20(1.00)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C20(1.16)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C20(1.31)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C20(0.97)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C20(0.82)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C20(0.89)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C20(1.00)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C20(1.06)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C20(1.16)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C20(1.13)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C20(1.03)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C20(1.22)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C20(1.17)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C20(1.38)  LDD1050  [1]
 LDCM0462  CL7 HEK-293T C20(1.44)  LDD1060  [1]
 LDCM0469  CL76 HEK-293T C20(1.29)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C20(1.00)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C20(1.66)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C20(1.61)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C20(0.78)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C20(1.48)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C20(1.72)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C20(1.05)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C20(1.11)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C20(1.87)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C20(1.70)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C20(1.98)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C20(1.11)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C20(1.71)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C20(1.49)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C20(0.77)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C20(1.26)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C20(0.71)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C20(1.06)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C20(0.75)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C20(0.91)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C20(1.58)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C20(0.83)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C20(0.87)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C20(1.02)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C20(0.75)  LDD1092  [1]
 LDCM0427  Fragment51 HEK-293T C20(1.26)  LDD1025  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
SHC-transforming protein 3 (SHC3) . Q92529

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.