Details of the Target

General Information of Target

Target ID LDTP04742
Target Name Histone deacetylase 4 (HDAC4)
Gene Name HDAC4
Gene ID 9759
Synonyms
KIAA0288; Histone deacetylase 4; HD4; EC 3.5.1.98
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Histone deacetylase family, HD type 2 subfamily
Subcellular location
Nucleus
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1.
TTD ID
T63816
Uniprot ID
P56524
DrugMap ID
TTTQGH8
Ensemble ID
ENST00000345617.7
HGNC ID
HGNC:14063
ChEMBL ID
CHEMBL3524

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C952(20.59)  LDD0209  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C952(0.00); C777(0.00); C751(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C952(0.00); C777(0.00); C751(0.00); C194(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C952(0.00); C777(0.00); C751(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C751(0.82); C194(1.12)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C751(0.96); C194(0.94); C1048(1.33)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C751(1.14); C194(1.09)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C751(1.07); C194(1.06)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C751(1.06); C194(1.05)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C194(1.08)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C751(0.87); C194(1.13)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C751(1.05); C194(0.92); C1048(1.19)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C751(0.84); C194(1.38)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C751(1.15); C194(0.96); C1048(1.01)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C751(0.92); C194(1.06)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C751(0.72); C194(1.04); C1048(1.08)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C751(1.00); C194(1.01)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C194(1.04)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C194(0.97)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C751(0.86); C194(1.14)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C751(0.97); C194(0.92); C1048(0.97)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C751(0.96); C194(1.06)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C751(1.13); C194(0.92)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C751(0.87); C194(0.98); C1048(1.17)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C751(0.81); C194(0.97)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C751(1.08); C194(1.12)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C194(0.91)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C194(1.02)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C751(0.99); C194(1.24)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C751(1.13); C194(0.92); C1048(1.05)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C751(1.00); C194(1.13)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C751(0.98); C194(1.04)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C751(0.86); C194(1.18); C1048(1.18)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C751(1.05); C194(0.96)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C194(1.01)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C751(1.01); C194(1.06)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C194(0.88)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C751(0.84); C194(1.13)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C751(1.12); C194(1.11); C1048(1.12)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C751(0.94); C194(1.12)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C751(1.06); C194(1.06)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C751(0.87); C194(1.10); C1048(0.95)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C751(1.21); C194(1.06)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C194(1.04)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C194(0.93)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C751(0.97); C194(1.08)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C751(0.84); C194(1.12); C1048(1.11)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C751(1.04); C194(0.92); C1048(1.13)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C751(0.93); C194(1.05)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C751(0.92); C194(0.99)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C751(0.82); C194(1.07); C1048(1.12)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C751(1.04); C194(1.06)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C194(0.99)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C194(0.97)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C751(0.94); C194(1.05)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C751(0.93); C194(0.89); C1048(1.17)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C751(1.00); C194(0.92)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C751(0.96); C194(1.02)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C751(1.00); C194(0.96)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C751(0.91); C194(1.01); C1048(1.04)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C751(1.04); C194(0.93)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C194(0.94)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C194(0.95)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C194(1.00)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C194(1.11)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C751(1.03); C194(0.88); C1048(1.00)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C751(0.97); C194(1.15)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C194(0.93)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C751(0.95); C194(0.93)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C751(1.17); C194(1.07)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C751(0.93); C194(0.93)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C751(1.04); C194(1.15)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C751(1.27); C194(1.10)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C751(0.95); C194(1.10)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C751(1.02); C194(0.99)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C751(0.75); C194(0.94)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C751(1.10); C194(1.17)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C751(1.27); C194(0.86)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C751(1.02); C194(0.94)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C751(1.07); C194(1.12)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C194(0.98)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C751(1.21); C194(1.19)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C751(1.24); C194(0.87)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C751(0.86); C194(0.97)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C751(1.07); C194(0.99)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C751(0.83); C194(1.12)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C751(1.04); C194(0.95)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C751(0.85); C194(1.10)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C751(1.08); C194(0.99)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C751(0.96); C194(1.21)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C751(0.90); C194(0.97)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C194(0.87)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C751(0.94); C194(0.93)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C751(1.05); C194(1.04)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C751(1.05); C194(1.17)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C751(0.93); C194(0.95)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C751(0.96); C194(0.97)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C751(0.86); C194(1.12)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C751(0.89); C194(1.06)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C751(0.98); C194(0.94)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C751(0.88); C194(0.98)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C751(0.85); C194(1.11)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C751(1.39); C194(0.98)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C751(1.03); C194(0.80)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C751(0.90); C194(0.92)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C751(0.93); C194(1.08)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C751(1.20); C194(0.92); C1048(1.14)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C751(1.35); C194(0.93)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C751(1.19); C194(1.02)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C751(0.91); C194(1.01)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C751(0.98); C194(1.11); C1048(0.93)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C751(1.37); C194(1.04)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C194(0.99)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C194(0.96)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C751(1.00); C194(1.07)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C751(1.13); C194(1.18)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C751(1.03); C194(0.90)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C751(0.80); C194(1.05)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C751(0.93); C194(1.06)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C751(0.98); C194(0.97)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C751(0.99); C194(0.97); C1048(1.18)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C751(1.18); C194(1.02)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C751(0.90); C194(1.13)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C751(1.28); C194(0.98); C1048(0.82)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C751(1.20); C194(0.94)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C194(1.03)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C194(0.88)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C751(1.28); C194(0.96)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C751(0.92); C194(0.96)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C751(1.02); C194(0.93)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C751(0.93); C194(0.93)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C751(0.88); C194(0.97)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C751(1.15); C194(0.97); C1048(1.03)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C751(0.86); C194(0.98)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C751(0.94); C194(1.03)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C751(0.78); C194(1.26); C1048(0.90)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C751(1.18); C194(0.92)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C194(0.92)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C194(0.89)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C751(1.05); C194(0.95)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C751(0.87); C194(1.11)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C751(1.19); C194(1.07)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C751(1.16); C194(0.97)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C751(1.13); C194(1.08)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C751(1.50); C194(1.04); C1048(0.86)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C751(0.89); C194(0.97)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C751(0.99); C194(1.06)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C751(0.77); C194(1.03); C1048(1.10)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C751(1.08); C194(1.01)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C194(0.96)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C751(1.19); C194(0.89); C1048(1.12)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C194(0.92)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C751(1.06); C194(0.94)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C751(0.97); C194(0.99)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C751(1.06); C194(0.89)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C751(0.93); C194(0.98)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C751(1.05); C194(1.18)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C751(1.08); C194(0.95); C1048(0.95)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C751(1.07); C194(0.97)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C751(0.98); C194(0.90)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C751(0.96); C194(0.95); C1048(0.88)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C751(0.86); C194(0.97)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C751(1.41); C194(0.98)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C194(1.04)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C194(1.10)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C751(1.01); C194(1.04)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C751(1.01); C194(1.15)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C751(0.98); C194(0.99)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C751(0.97); C194(1.07)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C751(1.02); C194(0.90); C1048(1.25)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C751(1.05); C194(1.00)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C751(0.92); C194(1.02)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C751(1.17); C194(0.93)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C751(0.99); C194(1.12); C1048(1.30)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C751(1.32); C194(0.95)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C194(0.94)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C194(0.86)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C751(0.92); C194(0.97)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C751(1.05); C194(0.96)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C751(1.14); C194(0.94)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C751(0.98); C194(0.89)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C751(0.89); C194(1.14)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C751(0.84); C194(1.07); C1048(0.85)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C751(1.18); C194(0.92); C1048(0.83)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C751(0.97); C194(0.89)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C751(0.94); C194(1.02)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C751(1.03); C194(0.98); C1048(1.04)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C751(1.01); C194(0.92)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C194(1.26)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C194(0.96)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C751(1.56); C194(1.17)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C751(1.34); C194(1.18)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C751(1.02); C194(0.92)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C751(1.14); C194(0.85)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C751(1.04); C194(0.87)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C751(1.14); C194(1.11)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C194(1.04); C751(0.87)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C952(20.59)  LDD0209  [1]
 LDCM0024  KB05 SH4 C751(1.05)  LDD3321  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 4 (HDAC4) Histone deacetylase family P56524
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme family P63279
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
14-3-3 protein theta (YWHAQ) 14-3-3 family P27348
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myocyte-specific enhancer factor 2B (MEF2B) MEF2 family Q02080
Myocyte-specific enhancer factor 2C (MEF2C) MEF2 family Q06413
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Androgen receptor (AR) Nuclear hormone receptor family P10275
B-cell lymphoma 6 protein (BCL6) . P41182
Golgin-45 (BLZF1) . Q9H2G9
Runt-related transcription factor 3 (RUNX3) . Q13761
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 41 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ankyrin repeat and SOCS box protein 15 (ASB15) Ankyrin SOCS box (ASB) family Q8WXK1
Breast cancer metastasis-suppressor 1 (BRMS1) BRMS1 family Q9HCU9
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cysteine-rich DPF motif domain-containing protein 1 (CDPF1) CDPF1 family Q6NVV7
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
DPY30 domain-containing protein 1 (DYDC1) Dpy-30 family Q8WWB3
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Protein LDOC1 (LDOC1) LDOC1 family O95751
MIF4G domain-containing protein (MIF4GD) MIF4GD family A9UHW6
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Ankyrin repeat family A protein 2 (ANKRA2) . Q9H9E1
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
Huntingtin-associated protein 1 (HAP1) . P54257
PRKCA-binding protein (PICK1) . Q9NRD5
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Decitabine Small molecular drug DB01262
Phenylbutyric Acid Small molecular drug DB06819
Propanoic Acid Small molecular drug DB03766
Romidepsin Small molecular drug DB06176
Valproic Acid Small molecular drug DB00313
Vorinostat Small molecular drug DB02546
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Investigative
Click To Hide/Show 84 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(E)-8-biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Small molecular drug D0KE3I
2,2-bis(3-fluorophenyl)-n-hydroxyacetamide Small molecular drug D0A4HF
2,2-bis(4-chlorophenyl)-n-hydroxyacetamide Small molecular drug D0PK9V
2,2-bis(4-fluorophenyl)-n-hydroxyacetamide Small molecular drug D0FN5D
2-(Methylsulfonylthio)Ethyl 2-propylpentanoate Small molecular drug D0H1FZ
4-benzoylamino-n-hydroxy-benzamide Small molecular drug D09ZNU
4-butyrylamino-n-hydroxy-benzamide Small molecular drug D05LLX
4-chloro-n-(5-hydroxycarbamoyl-pentyl)-benzamide Small molecular drug D0A5LS
4-dimethylamino-n-(6-mercapto-hexyl)-benzamide Small molecular drug D06XNP
4-hydroxy-n-(5-hydroxycarbamoyl-pentyl)-benzamide Small molecular drug D04NSP
5-(4-chloro-phenyl)-pentanoic Acid Hydroxyamide Small molecular drug D0V2ZO
5-(4-hydroxyphenyl)-3h-1,2-dithiole-3-thione Small molecular drug D06IQB
5-mercapto-pentanoic Acid Phenylamide Small molecular drug D0D2KE
6-(2-bromo-acetylamino)-hexanoic Acid Phenylamide Small molecular drug D02MQM
6-benzenesulfinylhexanoic Acid Hydroxamide Small molecular drug D00ZSD
6-benzenesulfonylhexanoic Acid Hydroxamide Small molecular drug D05AHZ
6-mercapto-hexanoic Acid Phenylamide Small molecular drug D0B3ZM
6-phenoxy-hexane-1-thiol Small molecular drug D09YBN
6-phenylsulfanylhexanoic Acid Hydroxamide Small molecular drug D0S9JF
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D0B2ZJ
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Small molecular drug D0Z3BM
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D02WZK
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D05VFP
7-mercapto-heptanoic Acid Benzothiazol-2-ylamide Small molecular drug D0Z5KX
7-mercapto-heptanoic Acid Biphenyl-3-ylamide Small molecular drug D05XAN
7-mercapto-heptanoic Acid Biphenyl-4-ylamide Small molecular drug D01XWZ
7-mercapto-heptanoic Acid Phenylamide Small molecular drug D00SEE
7-mercapto-heptanoic Acid Pyridin-3-ylamide Small molecular drug D07FJU
7-mercapto-heptanoic Acid Quinolin-3-ylamide Small molecular drug D0T4IY
7-mercapto-n-(4-phenylthiazol-2-yl)Heptanamide Small molecular drug D02HVH
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Small molecular drug D0AX7B
8-mercapto-octanoic Acid Phenylamide Small molecular drug D0XZ9Q
8-oxo-8-phenyl-octanoic Acid Small molecular drug D0RU1X
8-oxo-8-phenyl-octanoic Acid Hydroxyamide Small molecular drug D0S0WK
9,9,9-trifluoro-8-oxo-nonanoic Acid Phenylamide Small molecular drug D00KFF
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Small molecular drug D05FEJ
Abexinostat Small molecular drug DB12565
Azumamide B Small molecular drug D0M1ZI
Azumamide C Small molecular drug D0Q9PO
Azumamide E Small molecular drug D0E9DD
Cyclo(-l-am7(S2py)-a2in-l-ala-d-pro-) Small molecular drug D02NVY
Cyclo(-l-am7(S2py)-aib-l-ala-d-pro-) Small molecular drug D0R3XO
Cyclo(-l-am7(S2py)-aib-l-ala-d-tic-) Small molecular drug D0N5RV
Cyclo(-l-am7(S2py)-aib-l-ph4-d-pro-) Small molecular drug D0X4QC
Cyclo(-l-am7(S2py)-aib-l-ph5-d-pro-) Small molecular drug D03PRG
Cyclo(-l-am7(S2py)-aib-l-phe-d-pro-) Small molecular drug D0Z6MI
Cyclo(-l-am7(S2py)-aib-l-phg-d-pro-) Small molecular drug D0G1EX
Cyclo(-l-am7(S2py)-aib-l-ser(Bzl)-d-pro-) Small molecular drug D0E8UH
Cyclo(-l-am7(S2py)-aib-l-ser-d-pro-) Small molecular drug D0U0EZ
Cyclo(-l-am7(S2py)-d-2mephe-l-ala-d-pro-) Small molecular drug D04CDZ
Cyclo(-l-am7(S2py)-d-a1in-l-ala-d-pro-) Small molecular drug D02NAF
Cyclo(-l-am7(S2py)-l-2mephe-l-ala-d-pro-) Small molecular drug D0Z6HR
Cyclo(-l-am7(S2py)-l-a1in-l-ala-d-pro-) Small molecular drug D00XTC
Cyclostellettamine Derivative Small molecular drug D0C0VP
Largazole Small molecular drug D0Z8PX
N-(2-mercapto-ethyl)-n'-phenyl-oxalamide Small molecular drug D0F0KS
N-(2-mercapto-ethyl)-n'-phenyl-succinamide Small molecular drug D01MFV
N-(5-hydroxycarbamoyl-pentyl)-4-nitro-benzamide Small molecular drug D0C2KD
N-(6-hydroxycarbamoyl-hexyl)-benzamide Small molecular drug D0YY9M
N-(6-mercapto-hexyl)-benzamide Small molecular drug D04HSS
N-hydroxy-2,2-diphenylacetamide Small molecular drug D03QOD
N-hydroxy-2,2-diphenylpropanamide Small molecular drug D0I4RK
N-hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Small molecular drug D04ZDI
N-hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Small molecular drug D0QO0L
N-hydroxy-4-(2-phenyl-butyrylamino)-benzamide Small molecular drug D06VBN
N-hydroxy-4-(4-phenyl-butyrylamino)-benzamide Small molecular drug D0S7WQ
N-hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Small molecular drug D0R5VG
N-hydroxy-4-(Pentanoylamino-methyl)-benzamide Small molecular drug D0Z7YS
N-hydroxy-4-(Phenylacetylamino-methyl)-benzamide Small molecular drug D02UTC
N-hydroxy-4-phenylacetylamino-benzamide Small molecular drug D01XXN
N-hydroxy-9,10-dihydroanthracene-9-carboxamide Small molecular drug D03BQS
N-hydroxy-9h-xanthene-9-carboxamide Small molecular drug D06IMY
Octanedioic Acid Bis-hydroxyamide Small molecular drug D07YZZ
Octanedioic Acid Hydroxyamide Pyridin-2-ylamide Small molecular drug D0E8KR
Octanedioic Acid Hydroxyamide Pyridin-4-ylamide Small molecular drug D04GGW
Psammaplin A Small molecular drug D0N0TS
Santacruzamate A Small molecular drug D09RKA
St-2987 Small molecular drug D0T0SK
St-3050 Small molecular drug D01YBR
Thioacetic Acid S-(6-phenylcarbamoyl-hexyl) Ester Small molecular drug D05GVY
Tmp269 Small molecular drug D0R7JA
222-trifluoro-1-{5-[(3-phenyl-56-dihydroimidazo[12-a]Pyrazin-7(8h)-yl)Carbonyl]Thiophen-2-yl}Ethane-11-diol . DB08613
N-hydroxy-4-(3-phenyl-propionylamino)-benzamide . D0R4BS
N-hydroxy-5-[(3-phenyl-56-dihydroimidazo[12-a]Pyrazin-7(8h)-yl)Carbonyl]Thiophene-2-carboxamide . DB07879
Patented
Click To Hide/Show 23 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid29671355-compound-12 Small molecular drug D0UE9B
Pmid29671355-compound-21 Small molecular drug D0LP1K
Pmid29671355-compound-23 Small molecular drug D00HXJ
Pmid29671355-compound-25 Small molecular drug D0RA0D
Pmid29671355-compound-31 Small molecular drug D0DI9S
Pmid29671355-compound-43 Small molecular drug D0BP8I
Pmid29671355-compound-45a Small molecular drug D0YN2T
Pmid29671355-compound-47a Small molecular drug D0L1NO
Pmid29671355-compound-47b Small molecular drug D0NG9V
Pmid29671355-compound-47c Small molecular drug D07KQB
Pmid29671355-compound-47d Small molecular drug D0SP7T
Pmid29671355-compound-50 Small molecular drug D0M7GG
Pmid29671355-compound-52 Small molecular drug D02YLT
Pmid29671355-compound-56 Small molecular drug D0CH8Q
Pmid29671355-compound-61 Small molecular drug D0JB4S
Pmid29671355-compound-62 Small molecular drug D07WAT
Pmid29671355-compound-67 Small molecular drug D0M0RE
Pmid29671355-compound-68b Small molecular drug D0GD6R
Pmid29671355-compound-70 Small molecular drug D08CYC
Pmid29671355-compound-71a Small molecular drug D0O1LX
Pmid29671355-compound-71b Small molecular drug D0BV4M
Pmid29671355-compound-72a Small molecular drug D03KOH
Pmid29671355-compound-72b Small molecular drug D0E7TU

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840