Details of the Target

General Information of Target

Target ID LDTP04616
Target Name Ornithine decarboxylase antizyme 1 (OAZ1)
Gene Name OAZ1
Gene ID 4946
Synonyms
OAZ; Ornithine decarboxylase antizyme 1; AZ1; ODC-Az
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNP
GPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQS
RLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNR
EDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE
Target Bioclass
Other
Family
ODC antizyme family
Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Uniprot ID
P54368
Ensemble ID
ENST00000602676.6
HGNC ID
HGNC:8095
ChEMBL ID
CHEMBL4523241

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C175(1.16)  LDD0814  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C175(1.16)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C175(1.13)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C175(1.11)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C175(1.10)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C175(1.12)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C175(0.86)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C175(1.32)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C175(1.09)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C175(1.10)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C175(1.28)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C175(1.34)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C175(1.16)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C175(1.15)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C175(0.70)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C175(0.83)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C175(1.04)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C175(0.90)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C175(0.64)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C175(0.86)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C175(0.94)  LDD0834  [1]
 LDCM0238  AC120 HEK-293T C175(0.98)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C175(0.75)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C175(0.68)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C175(0.71)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C175(0.77)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C175(0.79)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C175(0.85)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C175(0.78)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C175(0.96)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C175(1.36)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C175(1.02)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C175(0.91)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C175(1.23)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C175(1.04)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C175(0.99)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C175(0.93)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C175(0.94)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C175(1.19)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C175(0.95)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C175(1.17)  LDD0856  [1]
 LDCM0260  AC140 HEK-293T C175(1.10)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C175(1.05)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C175(0.89)  LDD0860  [1]
 LDCM0276  AC17 HEK-293T C175(1.02)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C175(1.08)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C175(0.86)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C175(1.07)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C175(0.94)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C175(0.90)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C175(0.67)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C175(0.90)  LDD0882  [1]
 LDCM0320  AC57 HEK-293T C175(1.13)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C175(1.20)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C175(1.28)  LDD0920  [1]
 LDCM0324  AC60 HEK-293T C175(1.02)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C175(0.97)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C175(1.15)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C175(0.98)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C175(1.05)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C175(1.12)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C175(1.37)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C175(1.12)  LDD0929  [1]
 LDCM0349  AC83 HEK-293T C175(1.02)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C175(0.97)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C175(0.87)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C175(0.91)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C175(0.80)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C175(0.99)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C175(0.78)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C175(0.91)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C175(0.82)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C175(1.04)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C175(0.80)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C175(0.90)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C175(0.83)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C175(0.67)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C175(1.08)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C175(1.12)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C175(1.21)  LDD0964  [1]
 LDCM0374  CL105 HEK-293T C175(0.66)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C175(0.78)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C175(0.94)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C175(0.70)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C175(0.64)  LDD0976  [1]
 LDCM0380  CL110 HEK-293T C175(0.62)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C175(0.59)  LDD0979  [1]
 LDCM0396  CL125 HEK-293T C175(0.85)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C175(0.94)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C175(1.17)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C175(1.56)  LDD0997  [1]
 LDCM0420  CL31 HEK-293T C175(0.47)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C175(0.69)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C175(1.03)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C175(0.49)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C175(0.81)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C175(0.64)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C175(0.66)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C175(0.63)  LDD1026  [1]
 LDCM0430  CL40 HEK-293T C175(0.65)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C175(0.55)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C175(0.74)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C175(0.78)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C175(1.11)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C175(0.66)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C175(0.40)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C175(0.36)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C175(0.46)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C175(0.46)  LDD1037  [1]
 LDCM0441  CL50 HEK-293T C175(0.36)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C175(0.54)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C175(0.67)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C175(0.49)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C175(0.45)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C175(0.72)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C175(0.40)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C175(0.43)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C175(0.95)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C175(0.66)  LDD1048  [1]
 LDCM0452  CL60 HEK-293T C175(0.48)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C175(0.67)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C175(0.39)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C175(0.37)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C175(0.70)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C175(0.97)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C175(0.42)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C175(0.99)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C175(0.83)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C175(0.43)  LDD1059  [1]
 LDCM0463  CL70 HEK-293T C175(0.79)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C175(0.50)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C175(1.00)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C175(0.47)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C175(0.39)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C175(0.89)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C175(0.58)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C175(1.17)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C175(0.92)  LDD1070  [1]
 LDCM0474  CL80 HEK-293T C175(1.06)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C175(0.74)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C175(0.91)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C175(0.58)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C175(0.47)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C175(0.78)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C175(0.88)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C175(0.56)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C175(0.99)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C175(1.00)  LDD1081  [1]
 LDCM0485  CL90 HEK-293T C175(0.93)  LDD1083  [1]
 LDCM0468  Fragment33 HEK-293T C175(0.39)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C175(0.82)  LDD1025  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.