Details of the Target

General Information of Target

Target ID LDTP04513
Target Name Arf-GAP domain and FG repeat-containing protein 1 (AGFG1)
Gene Name AGFG1
Gene ID 3267
Synonyms
HRB; RAB; RIP; Arf-GAP domain and FG repeat-containing protein 1; HIV-1 Rev-binding protein; Nucleoporin-like protein RIP; Rev-interacting protein; Rev/Rex activation domain-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASAKRKQEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLN
PPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSSAIPDFRDPQKVKEFLQEK
YEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKSLLGDSAPTLHLNKGTPSQ
SPVVGRSQGQQQEKKQFDLLSDLGSDIFAAPAPQSTATANFANFAHFNSHAAQNSANADF
ANFDAFGQSSGSSNFGGFPTASHSPFQPQTTGGSAASVNANFAHFDNFPKSSSADFGTFN
TSQSHQTASAVSKVSTNKAGLQTADKYAALANLDNIFSAGQGGDQGSGFGTTGKAPVGSV
VSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQPAS
SSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTPAPY
SLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQTKPVVTPFGQVAAAGVSSN
PFMTGAPTGQFPTGSSSTNPFL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication.
Uniprot ID
P52594
Ensemble ID
ENST00000310078.13
HGNC ID
HGNC:5175

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 SNV: p.A518T .
CAL62 SNV: p.A518T DBIA    Probe Info 
HCT116 SNV: p.A378V .
HDQP1 SNV: p.A375V DBIA    Probe Info 
MCAS SNV: p.P552L DBIA    Probe Info 
OVCAR4 SNV: p.F107L DBIA    Probe Info 
RAMOS Deletion: p.H305SfsTer7 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K12(5.04); K175(1.61)  LDD0277  [2]
DBIA
 Probe Info  		C89(1.45)  LDD3314  [3]
BTD
 Probe Info  		C89(0.91)  LDD2093  [4]
HHS-475
 Probe Info  		Y327(0.95)  LDD0264  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
5E-2FA
 Probe Info  		H305(0.00); H140(0.00)  LDD2235  [7]
m-APA
 Probe Info  		H172(0.00); H305(0.00); H140(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0147  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Methacrolein
 Probe Info  		K90(0.00); C89(0.00)  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
HHS-482
 Probe Info  		Y327(1.81)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C89(0.88); C29(0.62)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C29(1.05)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C89(0.91); C32(1.09)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C89(1.00); C32(1.08)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C89(1.03); C32(1.15)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C89(1.05); C32(1.06)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C89(1.10); C32(1.12)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C89(1.00); C32(1.05)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C89(0.80); C32(1.07)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C89(0.94); C32(1.10)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C89(0.98); C32(0.80)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C89(1.11); C32(0.99)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C89(1.02); C32(1.03)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C89(1.04); C32(1.06); C52(1.25)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C89(1.01); C32(1.08)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C89(1.01); C32(0.97)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C89(0.97); C49(1.18)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C89(0.88); C32(1.16)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C89(0.99); C32(0.95)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C89(1.01); C32(1.10)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C89(0.98); C32(0.95)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C89(0.95); C32(1.04); C52(0.93)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C89(1.01); C32(1.09)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C89(1.03); C32(1.19)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C89(0.90); C32(1.01)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C89(0.94); C49(0.92)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C89(0.92); C32(1.16)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C89(0.94); C32(1.29)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C89(0.98); C32(1.14)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C89(1.03); C32(0.92)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C89(1.08); C32(1.04); C52(1.01)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C89(1.12); C32(1.01)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C89(0.91); C32(1.11)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C89(1.02); C32(0.94)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C89(0.91); C49(0.77)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C89(0.90); C32(1.21)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C89(0.88); C32(1.02)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C89(1.06); C32(1.16)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C89(1.03); C32(0.96)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C89(0.99); C32(0.96); C52(0.96)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C89(1.02); C32(1.10)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C89(1.14); C32(1.04)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C89(0.99); C49(1.03)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C89(0.97); C32(1.12)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C89(1.02); C32(0.91); C52(0.91)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C89(0.97); C32(0.93)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C89(1.05); C32(1.03)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C89(0.99); C32(0.95)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C89(1.02); C32(1.01); C52(1.10)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C89(1.06); C32(1.09)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C89(0.95); C32(1.04)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C89(0.96); C49(0.94)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C89(0.87); C32(1.06)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C89(0.99); C32(1.10)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C89(1.06); C32(1.08)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C89(1.09); C32(1.06)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C89(1.01); C32(1.01)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C89(0.92); C32(0.96); C52(1.01)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C89(1.01); C32(1.15)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C89(0.98); C32(1.00)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C89(0.89); C49(1.00)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C89(0.92); C32(1.05)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C89(0.96); C49(1.06)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C89(1.04); C32(1.05); C52(1.20)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C89(0.93); C32(1.10)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C89(0.98); C49(1.23)  LDD1514  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C89(0.92); C32(0.93); C49(0.88); C52(1.25)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C89(0.93); C32(0.83)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C89(0.99); C32(1.00); C52(1.18)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C89(0.95); C32(1.03); C49(0.91); C52(0.98)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C89(0.94); C32(0.99)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C89(0.99); C32(1.06)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C89(1.03); C32(0.94); C52(1.12)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C89(0.93); C32(0.98); C49(0.96); C52(0.91)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C89(0.97); C32(1.04)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C89(0.98); C32(0.96)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C89(0.96); C32(0.90); C52(0.95)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C89(0.96); C32(1.05); C49(0.90); C52(0.95)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C89(0.94); C32(0.98)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C89(0.90); C32(0.96)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C89(0.93); C32(0.98)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C89(0.94); C32(0.97); C52(1.09)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C89(0.96); C32(0.96); C49(0.85); C52(1.10)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C89(0.91); C32(0.91)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C89(0.96); C32(1.03)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C89(0.95); C32(0.98); C52(1.13)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C89(0.97); C32(1.00); C49(0.91); C52(1.05)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C89(0.99); C32(1.02)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C89(0.99); C32(1.07)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C89(1.05); C49(0.94)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C89(0.97); C32(1.00); C52(0.97)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C89(0.95); C32(0.97); C49(1.13); C52(1.10)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C89(0.98); C32(0.98)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C89(0.88); C32(0.95)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C89(0.99); C32(1.02); C52(0.92)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C89(0.99); C32(0.97); C49(0.91); C52(1.29)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C89(0.93); C32(1.06)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C89(0.95); C32(1.05)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C89(0.95); C32(0.96); C52(0.98)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C89(0.90); C32(0.86); C49(0.79); C52(1.12)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C89(0.96); C32(1.01)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C89(0.82); C32(0.85)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C89(0.97); C32(1.02); C52(1.50)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C89(0.78); C32(1.00)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C89(0.98); C32(1.11)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C89(1.02); C32(1.18)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C89(0.97); C32(1.02)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C89(1.02); C32(1.10)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C89(0.89); C32(1.01); C52(0.96)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C89(1.03); C32(0.91)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C89(0.83); C32(1.05)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C89(1.11); C49(0.92)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C89(1.00); C32(0.90); C49(0.93); C52(0.99)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C89(1.04); C32(0.96)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C89(0.98); C32(1.00)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C89(1.00); C32(1.04); C52(0.94)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C89(1.03); C32(1.06)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C89(0.93); C32(0.97)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C89(1.12); C32(1.10)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C89(1.00); C32(1.08)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C89(1.04); C32(1.08)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C89(0.95); C32(0.94); C52(1.04)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C89(1.09); C32(0.96)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C89(1.05); C32(1.12)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C89(1.03); C49(0.81)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C89(0.97); C32(0.95); C49(0.92); C52(1.18)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C89(0.96); C32(0.91)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C89(0.94); C32(0.91); C52(1.03)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C89(1.05); C32(0.94); C52(0.97)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C89(0.90); C32(0.97)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C89(1.07); C32(1.16)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C89(1.13); C32(1.02)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C89(1.00); C32(1.09)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C89(0.97); C32(1.05); C52(0.82)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C89(1.04); C32(0.90)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C89(0.86); C32(1.09)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C89(1.01); C49(0.99)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C89(0.94); C32(0.96); C49(0.84); C52(1.06)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C89(0.90); C32(1.05)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C89(0.95); C32(0.99)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C89(0.93); C32(0.98); C52(1.00)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C89(0.89); C32(1.07)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C89(0.86); C32(1.13)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C89(1.09); C32(1.08)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C89(0.98); C32(1.15)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C89(0.97); C32(1.03); C52(1.03)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C89(1.13); C32(1.05)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C89(1.02); C32(1.06)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C89(0.88); C32(1.03)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C89(1.04); C49(0.94)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C89(1.04); C32(0.93); C49(0.98); C52(1.04)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C89(1.05); C32(0.99)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C89(1.00); C32(1.14)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C89(0.89); C32(0.98); C52(1.13)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C89(0.92); C32(1.07)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C89(1.00); C32(1.08)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C89(1.06); C32(1.18)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C89(1.10); C32(1.10)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C89(1.05); C32(1.02); C52(0.87)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C89(0.99); C32(1.24)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C89(1.14); C32(1.01)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C89(1.05); C32(1.19)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C89(1.01); C49(0.87)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C89(0.94); C32(0.97); C49(0.83); C52(1.15)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C89(1.02); C32(0.97)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C89(0.98); C32(0.99); C52(0.95)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C89(0.78); C32(0.97)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C89(1.01); C32(1.02)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C89(1.11); C32(1.04)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C89(0.86); C32(0.85)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C89(1.12); C32(0.95)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C89(1.04); C32(1.08); C52(0.90)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C89(1.07); C32(0.97)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C89(0.96); C32(1.03)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C89(0.95); C49(0.93)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C89(1.08); C32(0.88); C49(0.87); C52(1.21)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C89(1.00); C32(0.92)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C89(1.00); C32(1.01)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C89(0.98); C32(1.09); C52(0.91)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C89(0.94); C32(1.07)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C89(1.01); C32(0.97); C52(0.82)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C89(0.86); C32(0.93)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C89(1.13); C32(1.08)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C89(1.03); C32(0.99)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C89(1.02); C32(1.00); C52(1.03)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C89(1.06); C32(1.07)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C89(0.84); C32(0.99)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C89(0.95); C49(0.98)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C89(0.94); C32(0.90); C49(0.95); C52(0.92)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C89(0.95); C32(1.02)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C89(0.98); C32(0.95)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C89(0.95); C32(0.93)  LDD1698  [13]
 LDCM0586  Fragment28 Ramos C89(0.19)  LDD2198  [14]
 LDCM0468  Fragment33 HEK-293T C89(0.97); C32(1.01)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C89(1.00); C32(0.97)  LDD1631  [13]
 LDCM0569  Fragment7 Ramos C89(0.20)  LDD2186  [14]
 LDCM0116  HHS-0101 DM93 Y327(0.95)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y327(1.56)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y327(1.08)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y327(0.50)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y327(0.64)  LDD0268  [5]
 LDCM0022  KB02 HEK-293T C89(0.94); C32(0.94)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C89(1.05); C32(0.99)  LDD1497  [13]
 LDCM0024  KB05 IGR37 C89(1.45)  LDD3314  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C89(0.91)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C89(1.00)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C89(2.27)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C89(1.08); C29(0.96)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C89(0.55)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C89(1.07)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C89(1.93)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C89(0.91); C29(0.79)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C89(1.38)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C89(1.11)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C89(1.02)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C89(1.41)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C89(1.12); C29(0.57)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C89(1.15)  LDD2136  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C89(1.15); C29(0.87)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C89(2.33)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C89(0.81)  LDD2146  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C89(1.05)  LDD2207  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase epsilon subunit 2 (POLE2) DNA polymerase epsilon subunit B family P56282
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 (NYAP2) NYAP family Q9P242
Vesicle-associated membrane protein 7 (VAMP7) Synaptobrevin family P51809
Epidermal growth factor receptor substrate 15 (EPS15) . P42566

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.