Details of the Target

General Information of Target

Target ID LDTP04368
Target Name Max-interacting protein 1 (MXI1)
Gene Name MXI1
Gene ID 4601
Synonyms
BHLHC11; Max-interacting protein 1; Max interactor 1; Class C basic helix-loop-helix protein 11; bHLHc11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERVKMINVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSG
SSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLE
EAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVD
VESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
Uniprot ID
P50539
Ensemble ID
ENST00000239007.11
HGNC ID
HGNC:7534

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C64(1.84)  LDD3418  [1]
CY-1
 Probe Info  		N.A.  LDD0246  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C100(0.90)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C100(1.05)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C100(1.29)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C100(1.01)  LDD1513  [4]
 LDCM0278  AC19 HEK-293T C100(0.95)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C100(0.85)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C100(1.16)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C100(0.77)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C100(0.80)  LDD1523  [4]
 LDCM0287  AC27 HEK-293T C100(0.87)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C100(0.88)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C100(0.85)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C100(1.03)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C100(1.10)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C100(0.95)  LDD1532  [4]
 LDCM0296  AC35 HEK-293T C100(0.94)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C100(1.12)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C100(1.08)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C100(0.81)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C100(1.12)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C100(0.98)  LDD1541  [4]
 LDCM0305  AC43 HEK-293T C100(0.89)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C100(1.08)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C100(0.98)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C100(0.97)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C100(1.01)  LDD1549  [4]
 LDCM0314  AC51 HEK-293T C100(0.92)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C100(1.02)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C100(1.25)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C100(0.89)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C100(1.15)  LDD1558  [4]
 LDCM0322  AC59 HEK-293T C100(1.09)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C100(1.04)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C100(1.05)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C100(1.06)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C100(1.17)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C100(1.08)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C100(0.94)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C100(1.00)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C100(1.00)  LDD1514  [4]
 LDCM0368  CL10 HEK-293T C100(1.21)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C100(0.84)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C100(0.84)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C100(0.86)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C100(1.05)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C100(0.93)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C100(1.29)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C100(0.89)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C100(0.98)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C100(0.93)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C100(0.96)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C100(0.86)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C100(0.86)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C100(0.95)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C100(0.85)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C100(0.99)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C100(1.00)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C100(0.93)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C100(0.90)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C100(0.97)  LDD1607  [4]
 LDCM0406  CL19 HEK-293T C100(1.06)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C100(0.94)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C100(1.18)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C100(1.12)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C100(0.80)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C100(0.80)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C100(0.88)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C100(0.70)  LDD1620  [4]
 LDCM0420  CL31 HEK-293T C100(0.56)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C100(0.80)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C100(0.71)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C100(0.72)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C100(0.64)  LDD1629  [4]
 LDCM0429  CL4 HEK-293T C100(0.96)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C100(0.85)  LDD1634  [4]
 LDCM0433  CL43 HEK-293T C100(1.01)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C100(0.98)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C100(1.05)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C100(1.00)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C100(0.74)  LDD1642  [4]
 LDCM0441  CL50 HEK-293T C100(0.87)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C100(0.70)  LDD1646  [4]
 LDCM0446  CL55 HEK-293T C100(0.70)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C100(0.70)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C100(0.89)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C100(1.01)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C100(0.73)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C100(0.96)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C100(0.76)  LDD1659  [4]
 LDCM0459  CL67 HEK-293T C100(0.86)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C100(0.88)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C100(0.88)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C100(0.99)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C100(0.85)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C100(0.83)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C100(0.97)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C100(0.71)  LDD1672  [4]
 LDCM0472  CL79 HEK-293T C100(0.62)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C100(1.39)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C100(0.70)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C100(0.84)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C100(0.97)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C100(0.53)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C100(0.98)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C100(0.87)  LDD1685  [4]
 LDCM0486  CL91 HEK-293T C100(0.82)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C100(1.11)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C100(1.01)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C100(1.35)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C100(0.82)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C100(0.83)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C100(0.94)  LDD1631  [4]
 LDCM0022  KB02 CC-LP-1 C64(3.10)  LDD2298  [1]
 LDCM0023  KB03 CC-LP-1 C64(3.17)  LDD2715  [1]
 LDCM0024  KB05 SG231 C64(1.84)  LDD3418  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate phosphatase ENTPD5 (ENTPD5) GDA1/CD39 NTPase family O75356
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Protein max (MAX) MAX family P61244
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Platelet endothelial aggregation receptor 1 (PEAR1) MEGF family Q5VY43
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402