Details of the Target

General Information of Target

Target ID LDTP04012
Target Name Excitatory amino acid transporter 3 (SLC1A1)
Gene Name SLC1A1
Gene ID 6505
Synonyms
EAAC1; EAAT3; HEAAC1; Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A1 subfamily
Subcellular location
Cell membrane
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate . Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.
TTD ID
T31721
Uniprot ID
P43005
DrugMap ID
TTG2A6F
Ensemble ID
ENST00000262352.8
HGNC ID
HGNC:10939
ChEMBL ID
CHEMBL2721

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C343(1.28)  LDD3341  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C343(1.07)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C343(1.20)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C343(1.15)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C343(0.89)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C343(1.00)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C343(0.96)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C343(1.09)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C343(1.00)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C343(1.16)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C343(0.96)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C343(1.19)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C343(1.00)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C343(0.96)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C343(0.97)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C343(0.99)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C343(1.18)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C343(1.17)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C343(1.08)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C343(0.90)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C343(0.89)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C343(1.01)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C343(1.01)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C343(0.93)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C343(1.04)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C343(1.15)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C343(1.05)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C343(1.04)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C343(0.88)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C343(0.95)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C343(0.95)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C343(1.05)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C343(0.91)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C343(0.98)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C343(1.21)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C343(1.14)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C343(1.13)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C343(1.02)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C343(0.97)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C343(0.98)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C343(1.03)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C343(1.03)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C343(1.23)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C343(0.98)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C343(0.99)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C343(1.03)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C343(0.85)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C343(0.91)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C343(1.08)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C343(1.07)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C343(1.07)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C343(1.17)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C343(1.09)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C343(1.05)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C343(0.99)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C343(1.20)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C343(0.98)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C343(0.99)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C343(0.96)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C343(1.10)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C343(0.99)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C343(0.96)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C343(1.00)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C343(1.13)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C343(1.04)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C343(1.19)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C343(1.52)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C343(1.03)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C343(1.00)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C343(1.21)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C343(1.15)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C343(1.09)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C343(0.97)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C343(1.11)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C343(1.03)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C343(1.20)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C343(1.06)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C343(1.13)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C343(1.29)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C343(1.10)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C343(1.12)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C343(0.94)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C343(1.44)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C343(1.02)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C343(1.04)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C343(1.01)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C343(1.10)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C343(1.03)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C343(1.01)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C343(1.09)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C343(1.12)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C343(1.21)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C343(1.29)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C343(1.19)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C343(1.27)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C343(1.16)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C343(1.22)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C343(1.08)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C343(1.17)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C343(1.14)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C343(1.40)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C343(1.06)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C343(1.47)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C343(1.09)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C343(1.13)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C343(1.11)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C343(0.94)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C343(1.12)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C343(1.08)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C343(1.07)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C343(1.06)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C343(1.48)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C343(1.07)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C343(1.03)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C343(1.04)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C343(1.11)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C343(1.08)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C343(1.00)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C343(1.16)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C343(0.94)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C343(1.41)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C343(1.13)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C343(1.04)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C343(1.15)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C343(1.20)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C343(1.13)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C343(1.25)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C343(0.97)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C343(1.15)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C343(0.96)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C343(1.08)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C343(0.88)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C343(1.22)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C343(1.12)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C343(1.17)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C343(1.17)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C343(1.22)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C343(1.19)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C343(1.26)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C343(1.17)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C343(1.34)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C343(1.32)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C343(1.07)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C343(0.87)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C343(1.23)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C343(1.06)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C343(1.26)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C343(1.26)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C343(1.06)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C343(1.12)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C343(1.01)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C343(1.00)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C343(1.21)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C343(1.14)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C343(1.16)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C343(1.06)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C343(0.85)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C343(1.12)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C343(1.09)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C343(1.10)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C343(1.09)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C343(1.04)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C343(1.25)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C343(1.09)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C343(1.09)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C343(1.36)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C343(1.05)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C343(1.09)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C343(1.51)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C343(0.80)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C343(1.18)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C343(1.04)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C343(1.12)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C343(1.21)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C343(1.47)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C343(1.14)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C343(1.21)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C343(1.07)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C343(1.25)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C343(1.04)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C343(1.69)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C343(1.06)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C343(1.06)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C343(1.20)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C343(1.03)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C343(1.50)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C343(1.23)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C343(1.16)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C343(1.10)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C343(0.99)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C343(1.11)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C343(1.17)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C343(1.07)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C343(0.95)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C343(0.98)  LDD1497  [4]
 LDCM0024  KB05 NCI-H1048 C343(1.28)  LDD3341  [1]
 LDCM0628  OTUB2-COV-1 HEK-293T C343(1.23)  LDD2207  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
P antigen family member 1 (PAGE1) GAGE family O75459
Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1) LDLR family Q5T700
Synaptoporin (SYNPR) Synaptophysin/synaptobrevin family Q8TBG9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aspartic Acid Small molecular drug DB00128
Glutamic Acid Small molecular drug DB00142
Pregabalin Small molecular drug DB00230
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-aspartic Acid Small molecular drug D08CAB
Dl-tboa Small molecular drug D07GUB
L-beta-ba Small molecular drug D09HET
Nbi-59159 Small molecular drug D0F5SO
[3h]Etb-tboa Small molecular drug D07CIW

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.