Details of the Target

General Information of Target

Target ID LDTP03758
Target Name Fibrillin-2 (FBN2)
Gene Name FBN2
Gene ID 2201
Synonyms
Fibrillin-2 [Cleaved into: Placensin]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRRRRLCLQLYFLWLGCVVLWAQGTAGQPQPPPPKPPRPQPPPQQVRSATAGSEGGFLA
PEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG
DGFCSRPNMCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVC
ENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCC
ATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFE
CRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCID
QRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDG
LPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGG
QGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECT
SNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQC
ICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVD
ECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFP
GAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICA
NGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPG
YVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWL
NIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECE
VFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF
RMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAF
PGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFEC
ECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVD
INECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNS
EGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDM
KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDM
HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF
TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNI
CVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPP
DFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCET
CPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQG
YYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC
YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFD
IHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL
CQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICH
NGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSF
FGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFR
CICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR
QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHG
TVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIG
NPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP
IGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDEN
ECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASS
SRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLC
TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRG
YVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPS
LCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCP
QGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECS
SSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPE
ACYECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILE
LRPAIQPLNNHIRYVISQGNDDSVFRIHQRNGLSYLHTAKKKLMPGTYTLEITSIPLYKK
KELKKLEESNEDDYLLGELGEALRMRLQIQLY
Target Bioclass
Other
Family
Fibrillin family
Subcellular location
Secreted; Secreted, extracellular space, extracellular matrix
Function
[Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.; [Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels.
Uniprot ID
P35556
Ensemble ID
ENST00000262464.9
HGNC ID
HGNC:3604

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.C280Ter DBIA    Probe Info 
COLO679 SNV: p.R999C DBIA    Probe Info 
COLO792 SNV: p.G455E DBIA    Probe Info 
HCC15 Deletion: p.D2138TfsTer111 DBIA    Probe Info 
HCT116 SNV: p.C1606Y .
HCT15 SNV: p.G583V; p.D1734Y .
HEC1 SNV: p.E846D DBIA    Probe Info 
HEC1B SNV: p.E846D .
HT SNV: p.P1623L; p.Y2521D .
IPC298 SNV: p.G1239D DBIA    Probe Info 
JURKAT SNV: p.Q2370Ter; p.G2731V .
KMCH1 SNV: p.I328L; p.P2324S DBIA    Probe Info 
KU1919 SNV: p.G2208A DBIA    Probe Info 
KYSE30 SNV: p.R1640I .
LS180 SNV: p.Q2777K .
MDAMB436 SNV: p.M1320I DBIA    Probe Info 
MEWO SNV: p.G1062E DBIA    Probe Info 
MFE296 Insertion: p.N614KfsTer4 .
MFE319 SNV: p.C1142R DBIA    Probe Info 
MOLT4 SNV: p.E2423D .
NCIH1048 SNV: p.R717C .
NCIH1793 SNV: p.G120V DBIA    Probe Info 
NCIH2170 SNV: p.N1218K .
NCIH2172 SNV: p.P444Q DBIA    Probe Info 
NCIH358 SNV: p.K570N; p.G1635R DBIA    Probe Info 
NCIH661 SNV: p.G428V .
NCIH82 Deletion: p.Y2521MfsTer90 .
OPM2 SNV: p.V407F .
OV90 SNV: p.A1032V .
OVK18 SNV: p.E2494K DBIA    Probe Info 
RL952 SNV: p.I495T .
SKNAS SNV: p.C706S .
SNGM SNV: p.M702I .
SW1271 Substitution: p.G2375F .
SW403 SNV: p.S597N DBIA    Probe Info 
SW620 Deletion: p.Q41PfsTer13 .
TE8 SNV: p.W1007G .
TFK1 SNV: p.C1764Y DBIA    Probe Info 
THP1 SNV: p.V2172A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
DBIA
 Probe Info  		C898(4.37); C821(5.06); C826(5.06); C808(6.61)  LDD0080  [2]
m-APA
 Probe Info  		N.A.  LDD2232  [3]
IA-alkyne
 Probe Info  		C375(0.00); C1052(0.00); C2321(0.00); C641(0.00)  LDD0165  [4]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
IPM
 Probe Info  		C115(0.00); C124(0.00); C119(0.00)  LDD2156  [6]
AOyne
 Probe Info  		6.50  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1084(1.14); C89(0.91); C115(1.08); C519(0.64)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C1084(1.10); C89(1.11); C2733(1.13); C935(1.16)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C1084(1.08); C89(1.02)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C1084(1.00); C89(1.03); C1100(0.92); C395(1.33)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C1084(0.96); C149(1.13); C115(0.94); C519(0.95)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C1084(0.98); C1100(1.32); C149(0.96); C395(1.33)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C1084(0.95); C89(0.99); C115(0.89); C519(1.32)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C1084(1.05); C89(1.06); C2733(1.20); C935(0.92)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C1084(1.33); C89(1.65)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C1084(1.06); C89(1.08); C2733(0.97); C935(1.04)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C1084(0.97); C89(1.03); C1100(1.01); C395(1.22)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C89(1.06); C1791(1.02); C935(1.01); C519(0.97)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C1084(0.96); C149(1.12); C115(0.99); C519(0.82)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C1084(1.01); C1100(1.20); C149(0.91); C395(1.27)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C1084(0.89); C89(1.05); C519(0.79); C1876(0.92)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C1084(0.96); C89(0.96); C115(1.13); C519(0.90)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C1084(1.02); C89(1.12); C2733(1.12); C935(0.91)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C1084(1.06); C89(1.01)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C1084(1.02); C89(1.01); C1100(1.20); C395(1.18)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C89(1.19); C1791(0.90); C935(0.98); C519(0.98)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C1084(1.10); C89(0.97)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C1084(1.09); C149(1.02); C115(1.05); C519(0.82)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C1084(0.99); C1100(0.98); C149(0.94); C395(0.91)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C1084(0.91); C89(0.95); C519(0.86); C1876(1.07)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C1084(1.06); C89(1.11); C115(1.13); C519(1.05)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C1084(1.06); C89(1.17); C2733(1.16); C935(1.00)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C1084(1.13); C89(0.96)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C1084(1.04); C89(1.11); C1100(1.09); C395(1.22)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C89(1.17); C1791(1.11); C935(1.12); C519(1.20)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C1084(1.09); C149(0.97); C115(1.12); C519(1.15)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C1084(0.98); C1100(0.99); C149(0.89); C395(1.07)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C1084(1.06); C89(0.92); C1100(1.04); C395(1.01)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C1084(0.95); C89(1.17); C519(1.09); C1876(1.01)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C1084(0.95); C89(0.93); C115(0.99); C519(0.95)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C1084(1.04); C89(1.24); C2733(1.06); C935(1.07)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C1084(1.08); C89(0.93)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C1084(0.95); C89(1.01); C1100(1.11); C395(1.33)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C89(1.18); C1791(1.01); C935(0.88); C519(1.05)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C1084(1.14); C149(1.05); C115(1.05); C519(0.87)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C1084(1.14); C1100(1.29); C149(0.88); C395(1.14)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C1084(0.93); C89(1.10); C519(0.86); C1876(0.92)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C1084(0.93); C89(1.12); C115(0.99); C519(0.79)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C89(1.23); C1791(1.14); C935(0.89); C519(0.78)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C1084(1.06); C89(1.08); C2733(1.03); C935(1.15)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C1084(1.10); C89(0.92)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C1084(1.00); C89(1.16); C1100(1.19); C395(1.17)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C89(1.15); C1791(1.09); C935(1.10); C519(0.97)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C1084(1.07); C149(1.16); C115(1.09); C519(1.01)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C1084(1.06); C1100(1.04); C149(0.90); C395(1.25)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C1084(1.00); C89(1.12); C519(0.91); C1876(1.09)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C1084(1.03); C89(0.97); C115(0.96); C519(0.86)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C1084(1.11); C89(1.08); C2733(1.08); C935(1.00)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C1084(1.16); C89(1.00)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C1084(1.20); C149(0.94); C115(0.93); C519(0.89)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C1084(1.04); C89(1.07); C1100(0.88); C395(1.22)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C89(1.15); C1791(1.19); C935(0.88); C519(1.06)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C1084(1.23); C149(0.90); C115(0.93); C519(0.96)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C1084(1.13); C1100(1.05); C149(0.87); C395(0.99)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C1084(1.03); C89(1.06); C519(0.79); C1876(0.95)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C1084(1.01); C1100(0.96); C149(0.89); C395(1.01)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C1084(0.96); C89(1.17); C519(0.84); C1876(0.97)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C89(1.23); C1791(1.04); C935(1.02); C519(0.85)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C1084(0.96); C89(1.06); C115(0.94); C519(1.03)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C1084(0.94); C89(1.09); C519(1.00); C1876(0.96)  LDD1514  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0367  CL1 HEK-293T C1084(0.98); C89(1.23); C2733(1.21); C1100(1.01)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C1084(0.85); C149(2.22); C115(0.93); C519(2.75)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C1084(1.09); C89(1.05)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C1084(1.23); C89(0.92); C2733(1.28); C1100(0.96)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C89(1.03)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C1084(0.98); C89(1.02); C1100(1.03); C519(0.79)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C1084(1.15); C89(0.92)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C1084(0.95); C89(1.26); C2733(1.18); C1100(0.74)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C89(1.18)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C1084(0.89); C89(1.10); C1100(1.00); C519(0.69)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C1084(1.08); C89(1.00)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C1084(0.94); C89(1.01); C2733(0.97); C1100(1.05)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C1084(0.83); C1100(1.18); C149(1.15); C395(1.98)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C89(1.08)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C1084(0.97); C89(1.00); C1100(0.84); C519(1.11)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C1084(1.01); C89(1.00)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C1084(1.22); C89(1.06); C2733(0.93); C1100(0.74)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C89(1.18)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C1084(0.88); C89(1.13); C1100(1.15); C519(1.18)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C1084(1.07); C89(0.91)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C1084(1.21); C89(0.94); C2733(1.03); C1100(1.27)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C89(1.15)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C1084(0.88); C89(1.04); C1100(0.97); C519(0.96)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C1084(0.73); C89(1.30); C519(1.49); C1876(0.92)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C1084(1.09); C89(0.98)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C1084(1.09); C89(0.97); C2733(1.19); C1100(0.93)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C89(1.09)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C1084(0.97); C89(0.95); C1100(1.10); C519(1.04)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C1084(1.08); C89(0.85)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C1084(1.22); C89(1.14); C2733(1.33); C1100(1.65)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C89(0.99)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C1084(1.00); C89(1.17); C1100(1.13); C519(0.91)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C1084(1.23); C89(1.01)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C1084(1.30); C89(1.08); C2733(1.14); C1100(1.08)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C89(1.06)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C1084(0.88); C89(1.20); C1100(1.16); C519(1.54)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C1084(1.10); C89(0.99)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C1084(0.87); C89(1.06); C115(0.94); C519(1.30)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C1084(0.88); C89(1.23); C2733(0.94); C935(1.24)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C1084(1.05); C89(0.96)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C89(1.08)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C1084(0.80); C89(1.04); C1100(1.19); C395(2.06)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C89(1.31); C1791(0.91); C935(1.13); C519(2.63)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C1084(0.78); C149(1.82); C115(1.04); C519(1.54)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C1084(0.77); C1100(1.58); C149(1.17); C395(2.06)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C1084(0.71); C89(1.25); C519(1.48); C1876(0.97)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C1084(1.03); C89(0.86); C2733(1.17); C1100(1.05)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C89(1.05)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C1084(0.91); C89(1.02); C1100(1.05); C519(0.98)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C1084(0.97); C89(0.89)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C1084(0.88); C89(0.96); C115(1.08); C519(1.07)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C1084(0.86); C89(0.99); C1100(1.16); C519(0.75)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C1084(0.87); C89(1.07); C2733(1.04); C935(0.89)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C1084(1.05); C89(0.96)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C1084(0.82); C89(0.92); C1100(1.34); C395(2.07)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C89(1.15); C1791(0.89); C935(1.03); C519(1.74)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C1084(0.73); C149(1.81); C115(1.01); C519(2.24)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C1084(0.79); C1100(1.45); C149(1.23); C395(2.17)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C1084(0.73); C89(1.07); C519(1.56); C1876(1.00)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C1084(1.25); C89(0.99); C2733(1.23); C1100(0.70)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C1084(0.95); C89(1.00); C1100(1.04); C519(1.08)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C1084(1.04); C89(0.92)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C1084(0.91); C89(0.98)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C1084(0.93); C89(0.95); C115(0.90); C519(0.92)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C1084(0.98); C89(1.01); C2733(1.10); C935(1.20)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C1084(1.02); C89(1.05)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C1084(0.95); C89(1.17); C1100(1.35); C395(1.82)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C89(1.20); C1791(0.90); C935(1.20); C519(2.18)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C1084(0.81); C149(1.77); C115(1.00); C519(2.02)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C1084(0.82); C1100(1.36); C149(1.18); C395(2.09)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C1084(0.77); C89(1.11); C519(2.20); C1876(1.02)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C1084(1.11); C89(0.90); C2733(1.00); C1100(0.88)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C1084(0.96); C89(1.06); C115(0.83); C519(1.77)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C89(1.08)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C1084(1.05); C89(0.85)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C1084(0.94); C89(1.01); C115(0.77); C519(1.96)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C1084(0.89); C89(1.16); C2733(0.98); C935(1.04)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C1084(1.03); C89(0.95)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C1084(0.90); C89(1.13); C1100(1.42); C395(1.82)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C89(1.57); C1791(0.95); C935(1.29); C519(0.31)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C1084(0.76); C149(1.70); C115(0.97); C519(1.68)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C1084(0.89); C1100(1.32); C149(1.32); C395(1.83)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C1084(0.93); C89(1.08); C2733(1.17); C935(1.07)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C1084(0.71); C89(1.19); C519(2.79); C1876(0.95)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C1084(1.22); C89(0.99); C2733(1.12); C1100(1.05)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C89(1.17)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C1084(0.97); C89(0.96); C1100(0.99); C519(0.92)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C1084(1.01); C89(1.00)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C1084(0.94); C89(1.01); C115(1.07); C519(0.96)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C1084(0.93); C89(1.09); C2733(1.14); C935(1.09)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C1084(1.07); C89(1.02)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C1084(0.89); C89(1.12); C1100(1.27); C395(1.88)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C89(1.27); C1791(1.06); C935(1.20); C519(1.59)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C1084(1.12); C89(1.09)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C1084(0.82); C149(1.69); C115(0.99); C519(2.36)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C1084(0.83); C1100(1.27); C149(1.19); C395(2.55)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C1084(0.74); C89(1.10); C519(2.34); C1876(1.04)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C1084(1.33); C89(0.82); C2733(1.31); C1100(0.96)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C89(1.05)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C1084(1.03); C89(0.83)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C1084(0.91); C89(1.01); C115(0.89); C519(1.55)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C1084(0.97); C89(1.06); C2733(1.11); C935(1.13)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C1084(1.01); C89(0.96)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C1084(0.93); C89(1.06); C1100(1.51); C395(2.11)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C1084(0.81); C89(1.12); C1100(1.28); C395(1.47)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C89(1.24); C1791(1.28); C935(1.29); C519(1.60)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C1084(0.85); C149(1.59); C115(1.07); C519(1.41)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C1084(0.88); C1100(1.31); C149(1.14); C395(1.75)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C1084(0.82); C89(1.04); C519(1.77); C1876(1.02)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C1084(1.26); C89(0.84); C2733(1.17); C1100(0.92)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C89(1.07)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C1084(0.90); C89(1.13); C1100(1.04); C519(0.77)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C1084(1.14); C89(0.95)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C1084(1.01); C89(1.07); C115(1.00); C519(1.06)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C89(1.45); C1791(1.12); C935(1.25); C519(1.72)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C1084(1.01); C89(1.15); C2733(1.02); C935(1.26)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C1084(1.07); C89(0.99)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C1084(0.97); C89(1.07); C1100(0.99); C395(1.63)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C89(1.27); C1791(1.06); C935(1.03); C519(1.39)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C1084(0.97); C149(1.61); C115(1.04); C519(2.00)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C1084(1.01); C1100(1.17); C149(1.03); C395(2.50)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C1084(0.93); C89(1.11); C519(1.03); C1876(0.93)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C1084(1.04); C89(0.97); C2733(1.09); C1100(0.83)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C89(1.02)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C1084(1.04); C89(1.18); C1100(1.02); C519(0.65)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C1084(0.85); C89(1.11); C1100(1.02); C519(1.30)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C1084(0.88); C89(0.97); C1100(1.05); C519(0.94)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C89(1.06)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C898(4.37); C821(5.06); C826(5.06); C808(6.61)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C898(6.82); C821(5.84); C826(5.84); C808(20.00)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C898(5.87); C821(4.63); C826(4.63); C808(4.58)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibrillin-1 (FBN1) Fibrillin family P35555
Fibronectin (FN1) . P02751

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402