Details of the Target

General Information of Target

Target ID LDTP03580
Target Name Homeobox protein Hox-A10 (HOXA10)
Gene Name HOXA10
Gene ID 3206
Synonyms
HOX1H; Homeobox protein Hox-A10; Homeobox protein Hox-1.8; Homeobox protein Hox-1H; PL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAH
GGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLD
APRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPK
VSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGP
FPAQPPGRGFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAE
ELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMY
LTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.
Uniprot ID
P31260
Ensemble ID
ENST00000283921.5
HGNC ID
HGNC:5100

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCFSTTG1 SNV: p.F159L .
HCC15 SNV: p.G95C .
HDQP1 SNV: p.C280Ter .
HEC1 SNV: p.T376M .
HT SNV: p.P144T .
KYSE150 SNV: p.A201V .
PF382 SNV: p.A201T .
REH SNV: p.S167N .
SNU1 Deletion: p.L349RfsTer21 .
UACC62 SNV: p.C280F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y110(5.24)  LDD0257  [1]
AHL-Pu-1
 Probe Info  		C78(2.21); C200(3.14)  LDD0168  [2]
DBIA
 Probe Info  		C200(2.67)  LDD0080  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		13.30  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C78(2.21); C200(3.14)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C78(2.13); C200(2.75)  LDD0169  [2]
 LDCM0215  AC10 HEK-293T C200(0.98)  LDD1508  [8]
 LDCM0237  AC12 HEK-293T C200(1.14)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C200(0.94); C20(0.97)  LDD1512  [8]
 LDCM0277  AC18 HEK-293T C200(1.08)  LDD1516  [8]
 LDCM0279  AC2 HEK-293T C200(1.21)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C200(1.17)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C200(0.85); C170(1.18)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C200(1.15); C20(1.00)  LDD1521  [8]
 LDCM0284  AC24 HEK-293T C200(0.96)  LDD1523  [8]
 LDCM0286  AC26 HEK-293T C200(1.08)  LDD1525  [8]
 LDCM0288  AC28 HEK-293T C200(1.07)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C200(0.94); C170(1.17)  LDD1528  [8]
 LDCM0291  AC30 HEK-293T C200(1.11); C20(0.96)  LDD1530  [8]
 LDCM0293  AC32 HEK-293T C200(1.15)  LDD1532  [8]
 LDCM0295  AC34 HEK-293T C200(1.26)  LDD1534  [8]
 LDCM0297  AC36 HEK-293T C200(1.10)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C200(0.93); C170(1.12)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C200(1.11); C20(0.94)  LDD1538  [8]
 LDCM0301  AC4 HEK-293T C200(1.18)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C200(1.14)  LDD1541  [8]
 LDCM0304  AC42 HEK-293T C200(1.08)  LDD1543  [8]
 LDCM0306  AC44 HEK-293T C200(1.16)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C200(1.03); C170(1.01)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C200(1.22); C20(1.20)  LDD1547  [8]
 LDCM0310  AC48 HEK-293T C200(1.12)  LDD1549  [8]
 LDCM0312  AC5 HEK-293T C200(0.85); C170(1.11)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C200(1.09)  LDD1552  [8]
 LDCM0315  AC52 HEK-293T C200(1.11)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C200(0.93); C170(1.24)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C200(0.93); C20(0.93)  LDD1556  [8]
 LDCM0319  AC56 HEK-293T C200(1.34)  LDD1558  [8]
 LDCM0321  AC58 HEK-293T C200(1.09)  LDD1560  [8]
 LDCM0323  AC6 HEK-293T C200(0.99); C20(0.66)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C200(1.04)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C200(1.02); C170(1.08)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C200(0.99); C20(1.01)  LDD1565  [8]
 LDCM0328  AC64 HEK-293T C200(1.04)  LDD1567  [8]
 LDCM0345  AC8 HEK-293T C200(1.09)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C200(0.86); C170(1.00)  LDD1511  [8]
 LDCM0275  AKOS034007705 HEK-293T C200(1.14)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C200(1.13); C20(0.74)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C200(0.96); C20(0.52)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C200(0.97)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C200(1.14); C20(0.80)  LDD1574  [8]
 LDCM0372  CL103 HEK-293T C200(0.96)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C200(1.26)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C200(1.23); C20(0.87)  LDD1578  [8]
 LDCM0376  CL107 HEK-293T C200(0.97)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C200(1.14)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C200(1.10); C20(0.93)  LDD1582  [8]
 LDCM0381  CL111 HEK-293T C200(1.22)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C200(1.15)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C200(1.17); C20(0.87)  LDD1587  [8]
 LDCM0385  CL115 HEK-293T C200(1.25)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C200(0.98)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C200(1.07); C20(1.03)  LDD1591  [8]
 LDCM0389  CL119 HEK-293T C200(1.11)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C200(1.14)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C200(1.09)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C200(1.03); C20(1.29)  LDD1596  [8]
 LDCM0394  CL123 HEK-293T C200(0.96)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C200(0.97)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C200(1.08); C20(1.51)  LDD1600  [8]
 LDCM0398  CL127 HEK-293T C200(1.12)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C200(1.02)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C200(1.37); C20(1.22)  LDD1604  [8]
 LDCM0402  CL15 HEK-293T C200(0.87)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C200(1.23)  LDD1607  [8]
 LDCM0405  CL18 HEK-293T C200(1.16)  LDD1609  [8]
 LDCM0408  CL20 HEK-293T C200(1.07)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C200(1.01); C170(1.23)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C200(1.27); C20(0.87)  LDD1614  [8]
 LDCM0412  CL24 HEK-293T C200(1.10)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C200(0.95); C20(1.08)  LDD1617  [8]
 LDCM0415  CL27 HEK-293T C200(1.14)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C200(1.08)  LDD1620  [8]
 LDCM0418  CL3 HEK-293T C200(1.21)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C200(1.11)  LDD1623  [8]
 LDCM0421  CL32 HEK-293T C200(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C200(0.79); C170(0.84)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C200(0.95); C20(0.81)  LDD1627  [8]
 LDCM0425  CL36 HEK-293T C200(1.08)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C200(1.06); C20(0.95)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C200(0.86)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C200(0.94)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C200(1.07)  LDD1634  [8]
 LDCM0432  CL42 HEK-293T C200(1.16)  LDD1636  [8]
 LDCM0434  CL44 HEK-293T C200(1.06)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C200(1.02); C170(0.95)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C200(1.07); C20(0.84)  LDD1640  [8]
 LDCM0438  CL48 HEK-293T C200(1.05)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C200(1.05); C20(1.07)  LDD1643  [8]
 LDCM0443  CL52 HEK-293T C200(0.98)  LDD1646  [8]
 LDCM0445  CL54 HEK-293T C200(1.04)  LDD1648  [8]
 LDCM0447  CL56 HEK-293T C200(0.99)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C200(0.93); C170(1.20)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C200(1.00); C20(1.26)  LDD1652  [8]
 LDCM0451  CL6 HEK-293T C200(1.14)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C200(1.12)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C200(1.12); C20(0.77)  LDD1656  [8]
 LDCM0455  CL63 HEK-293T C200(1.04)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C200(1.13)  LDD1659  [8]
 LDCM0458  CL66 HEK-293T C200(1.11)  LDD1661  [8]
 LDCM0460  CL68 HEK-293T C200(1.17)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C200(0.93); C170(0.96)  LDD1664  [8]
 LDCM0463  CL70 HEK-293T C200(1.14); C20(1.27)  LDD1666  [8]
 LDCM0465  CL72 HEK-293T C200(0.94)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C200(1.08); C20(0.88)  LDD1669  [8]
 LDCM0469  CL76 HEK-293T C200(0.94)  LDD1672  [8]
 LDCM0471  CL78 HEK-293T C200(1.18)  LDD1674  [8]
 LDCM0473  CL8 HEK-293T C200(1.21)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C200(1.07)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C200(0.95); C170(0.98)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C200(0.94); C20(0.62)  LDD1679  [8]
 LDCM0478  CL84 HEK-293T C200(1.06)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C200(1.07); C20(0.81)  LDD1682  [8]
 LDCM0481  CL87 HEK-293T C200(1.12)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C200(1.17)  LDD1685  [8]
 LDCM0484  CL9 HEK-293T C200(1.03); C170(1.00)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C200(0.99)  LDD1688  [8]
 LDCM0487  CL92 HEK-293T C200(1.07)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C200(0.94); C170(1.05)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C200(1.04); C20(0.73)  LDD1692  [8]
 LDCM0491  CL96 HEK-293T C200(1.44)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C200(1.11); C20(0.96)  LDD1695  [8]
 LDCM0494  CL99 HEK-293T C200(0.88)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C200(1.11)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C200(1.06)  LDD1671  [8]
 LDCM0022  KB02 HCT 116 C200(2.67)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C200(1.79)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C200(2.09)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor PU.1 (SPI1) ETS family P17947
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcitriol Small molecular drug DB00136

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402