Details of the Target

General Information of Target

Target ID LDTP03454
Target Name Receptor-type tyrosine-protein phosphatase mu (PTPRM)
Gene Name PTPRM
Gene ID 5797
Synonyms
PTPRL1; Receptor-type tyrosine-protein phosphatase mu; Protein-tyrosine phosphatase mu; R-PTP-mu; EC 3.1.3.48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
CYEVALEYLNSG
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Receptor class 2B subfamily
Subcellular location
Cell membrane
Function
Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation. Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function.
Uniprot ID
P28827
Ensemble ID
ENST00000332175.12
HGNC ID
HGNC:9675
ChEMBL ID
CHEMBL4661

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K234(1.53); K231(1.53); K375(5.30)  LDD3494  [1]
DBIA
 Probe Info  		C907(2.84)  LDD3319  [2]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C182(0.76)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C182(0.77)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C182(1.01)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C182(1.03)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C182(1.10)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C182(1.12)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C182(0.94)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C182(0.80)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C182(1.12)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C182(0.81)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C182(0.80)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C182(1.03)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C182(1.13)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C182(1.03)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C182(1.17)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C182(0.84)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C182(0.82)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C182(0.94)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C182(0.88)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C182(0.94)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C182(1.16)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C182(0.95)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C182(1.06)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C182(1.16)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C182(0.77)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C182(0.84)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C182(0.91)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C182(0.85)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C182(0.97)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C182(0.99)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C182(1.10)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C182(1.05)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C182(1.15)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C182(0.95)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C182(0.97)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C182(0.94)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C182(0.97)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C182(0.99)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C182(0.90)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C182(1.11)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C182(1.05)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C182(1.01)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C182(0.89)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C182(0.77)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C182(0.84)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C182(1.09)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C182(0.84)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C182(0.77)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C182(0.94)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C182(1.20)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C182(0.86)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C182(0.76)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C182(0.95)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C182(1.57)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C182(1.00)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C182(1.15)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C182(0.95)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C182(0.84)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C182(1.38)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C182(1.13)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C182(1.10)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C182(1.26)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C182(1.01)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C182(1.43)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C182(1.25)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C182(1.21)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C182(0.97)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C182(1.42)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C182(1.20)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C182(1.06)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C182(1.37)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C182(0.89)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C182(1.07)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C182(1.27)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C182(1.01)  LDD1583  [5]
 LDCM0381  CL111 HEK-293T C182(1.18)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C182(0.97)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C182(0.93)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C182(1.34)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C182(1.12)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C182(1.43)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C182(0.98)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C182(1.06)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C182(0.91)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C182(0.91)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C182(1.07)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C182(1.00)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C182(1.01)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C182(1.18)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C182(0.98)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C182(0.91)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C182(1.39)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C182(0.97)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C182(1.02)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C182(0.93)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C182(0.82)  LDD1610  [5]
 LDCM0408  CL20 HEK-293T C182(0.87)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C182(1.23)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C182(0.96)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C182(1.09)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C182(0.99)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C182(1.05)  LDD1617  [5]
 LDCM0415  CL27 HEK-293T C182(1.24)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C182(1.10)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C182(1.08)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C182(0.92)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C182(0.75)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C182(0.92)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C182(1.03)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C182(1.11)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C182(1.21)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C182(1.07)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C182(1.07)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C182(1.24)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C182(1.16)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C182(0.85)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C182(1.07)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C182(0.73)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C182(0.69)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C182(1.21)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C182(1.09)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C182(1.47)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C182(1.40)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C182(1.06)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C182(1.08)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C182(0.76)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C182(0.66)  LDD1644  [5]
 LDCM0443  CL52 HEK-293T C182(0.88)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C182(0.89)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C182(1.04)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C182(1.04)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C182(0.97)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C182(1.48)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C182(1.43)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C182(1.42)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C182(0.85)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C182(1.26)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C182(1.74)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C182(1.10)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C182(0.85)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C182(0.96)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C182(0.89)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C182(0.91)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C182(0.91)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C182(0.86)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C182(0.94)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C182(1.86)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C182(0.99)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C182(1.20)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C182(2.43)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C182(0.95)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C182(0.81)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C182(0.78)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C182(0.83)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C182(1.02)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C182(1.07)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C182(0.84)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C182(1.25)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C182(0.90)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C182(1.53)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C182(0.93)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C182(1.37)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C182(1.00)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C182(0.73)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C182(1.20)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C182(1.34)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C182(1.11)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C182(1.08)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C182(1.37)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C182(1.47)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C182(1.34)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C182(0.93)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C182(1.56)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C182(1.30)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C182(1.10)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C182(1.08)  LDD1671  [5]
 LDCM0022  KB02 HEK-293T C182(0.58)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C182(0.82)  LDD1497  [5]
 LDCM0024  KB05 MEWO C907(2.84)  LDD3319  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-type tyrosine-protein phosphatase mu (PTPRM) Protein-tyrosine phosphatase family P28827

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402