Details of the Target

General Information of Target

Target ID LDTP03451
Target Name DNA excision repair protein ERCC-5 (ERCC5)
Gene Name ERCC5
Gene ID 2073
Synonyms
ERCM2; XPG; XPGC; DNA excision repair protein ERCC-5; EC 3.1.-.-; DNA repair protein complementing XP-G cells; Xeroderma pigmentosum group G-complementing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
Target Bioclass
Enzyme
Family
XPG/RAD2 endonuclease family, XPG subfamily
Subcellular location
Nucleus
Function
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair . Makes the 3'incision in DNA nucleotide excision repair (NER). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble. Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA. Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II. Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity. Required for DNA replication fork maintenance and preservation of genomic stability. Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site. During HRR, binds to the replication fork with high specificity and stabilizes it. Also, acts upstream of HRR, to promote the release of BRCA1 from DNA.
Uniprot ID
P28715
Ensemble ID
ENST00000652225.2
HGNC ID
HGNC:3437
ChEMBL ID
CHEMBL4736

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.L918IfsTer12 DBIA    Probe Info 
CASKI SNV: p.K1027N DBIA    Probe Info 
HCT15 SNV: p.P882H DBIA    Probe Info 
HT Deletion: p.R216del DBIA    Probe Info 
KURAMOCHI SNV: p.P593L .
LNCaP clone FGC SNV: p.L1023I DBIA    Probe Info 
LS180 SNV: p.S477A DBIA    Probe Info 
MDST8 SNV: p.S674F DBIA    Probe Info 
OCUG1 SNV: p.E727K; p.E887K DBIA    Probe Info 
SNU308 SNV: p.R435K DBIA    Probe Info 
SW1116 Deletion: p.S133_T135del DBIA    Probe Info 
TOV21G SNV: p.D709H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1021(4.98); C12(9.12)  LDD0209  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		C529(0.00); C404(0.00)  LDD2224  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0005  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1021(0.90); C12(1.04)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C529(1.15); C1021(1.03)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C529(1.04)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C529(1.13); C1021(0.95)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C1021(1.11)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C1021(0.90)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C1021(0.94); C12(1.01)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C529(0.99); C1021(0.88)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C529(1.20)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C529(1.05); C1021(0.99)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C529(0.95); C1021(1.07)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C404(1.08); C1021(1.04); C12(0.97); C569(0.95)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C1021(1.40)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C1021(0.94)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C12(1.03)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C1021(0.94); C12(0.90)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C529(1.12); C1021(1.04)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C529(1.00)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C529(1.05); C1021(1.02)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C404(1.09); C1021(1.03); C12(0.83); C569(0.87)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C529(1.14)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C1021(1.13)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C1021(0.98)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C12(1.11)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C1021(1.00); C12(1.04)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C529(1.12); C1021(1.05)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C529(0.88)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C529(1.00); C1021(1.02)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C404(1.04); C1021(1.06); C12(0.94); C569(1.00)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C1021(1.21)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C1021(0.98)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C529(0.95); C1021(1.01)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C12(0.96)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C1021(0.98); C12(0.96)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C529(0.92); C1021(1.10)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C529(1.04)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C529(0.95); C1021(1.06)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C404(1.11); C1021(0.89); C12(0.94); C569(1.01)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C1021(1.01)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C1021(1.03)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C12(1.05)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C1021(0.98); C12(1.03)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C404(1.01); C1021(1.07); C12(0.93); C569(1.06)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C529(1.15); C1021(1.17)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C529(1.04)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C529(0.94); C1021(1.07)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C404(0.96); C1021(0.98); C12(0.95); C569(0.99)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C1021(1.13)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C1021(0.95)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C12(1.08)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C1021(0.96); C12(1.04)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C529(1.06); C1021(0.99)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C529(1.14)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C1021(1.02)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C529(0.93); C1021(0.87)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C404(1.00); C1021(0.87); C12(0.93); C569(0.94)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C1021(0.93)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C1021(1.00)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C12(1.12)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C1021(0.94)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C12(0.96)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C404(0.99); C1021(0.91); C12(0.94); C569(1.05)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C1021(0.93); C12(0.95)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C12(1.03)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C529(1.28); C1021(0.87)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C1021(1.72)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C529(1.06); C1021(1.02)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C529(1.09); C1021(1.13)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C529(0.94); C1021(0.99); C550(1.00)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C529(0.91); C1021(1.02)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C529(0.98); C1021(1.02)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C529(0.96); C1021(1.10)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C529(0.94); C1021(0.96); C550(1.50)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C529(1.02); C1021(1.05)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C529(0.93); C1021(0.90)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C529(1.10); C1021(0.97)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C1021(1.20)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C529(1.03); C1021(1.06); C550(0.88)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C529(1.16); C1021(0.81)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C529(1.23); C1021(0.98)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C529(1.03); C1021(1.17)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C529(1.22); C1021(1.01); C550(0.75)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C529(0.91); C1021(1.01)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C529(0.94); C1021(0.89)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C529(1.09); C1021(1.07)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C529(1.13); C1021(0.98); C550(1.41)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C529(1.20); C1021(1.06)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C12(1.03)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C529(0.97); C1021(1.02)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C529(1.14); C1021(1.02)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C529(1.25); C1021(1.02); C550(1.23)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C529(0.91); C1021(1.02)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C529(0.97); C1021(1.07)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C529(1.10); C1021(1.07)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C529(1.00); C1021(1.00); C550(0.89)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C529(1.32); C1021(0.91)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C529(1.08); C1021(0.92)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C529(1.13); C1021(1.23)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C529(0.97); C1021(0.93); C550(1.05)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C529(1.36); C1021(1.02)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C529(1.06); C1021(0.90)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C1021(1.00); C12(0.94)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C529(1.20); C1021(1.00)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C529(0.87)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C529(1.04); C1021(0.97); C550(1.10)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C529(1.04); C1021(1.05)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C404(1.05); C1021(1.20); C12(0.98); C569(1.11)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C1021(1.96)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C1021(1.18)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C12(1.07)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C529(1.08); C1021(0.99)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C529(1.10); C1021(0.99); C550(0.92)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C529(0.68); C1021(0.95)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C529(0.93); C1021(0.90)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C1021(0.96); C12(0.90)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C529(0.91); C1021(0.99)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C529(0.91); C1021(1.06)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C529(0.96)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C529(0.96); C1021(1.00)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C404(1.10); C1021(1.11); C12(1.04); C569(0.79)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C1021(1.86)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C1021(1.14)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C12(1.07)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C529(1.07); C1021(1.01)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C529(1.05); C1021(0.90)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C529(0.98); C1021(0.93)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C529(1.06); C1021(1.00)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C1021(0.99); C12(0.96)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C529(1.12); C1021(1.07)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C529(0.96)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C529(1.04); C1021(1.10)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C404(0.95); C1021(1.99); C12(0.94); C569(1.08)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C1021(1.47)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C1021(1.23)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C12(1.08)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C529(1.05); C1021(1.06)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C1021(0.91); C12(0.96)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C529(1.35); C1021(0.98); C550(0.88)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C529(0.90); C1021(0.94)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C1021(1.01); C12(1.00)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C529(0.92); C1021(1.06)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C529(1.16)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C529(1.10); C1021(1.25)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C404(0.98); C1021(1.50); C12(1.19); C569(0.99)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C1021(1.61)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C1021(1.12)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C529(1.21); C1021(1.07)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C12(1.12)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C529(1.00); C1021(1.12)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C529(1.05); C1021(0.97); C550(1.08)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C529(1.12); C1021(1.00)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C529(0.98); C1021(0.99)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C1021(0.91); C12(0.97)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C529(0.93); C1021(1.05)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C529(0.92)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C529(1.28); C1021(1.06)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C404(0.84); C1021(1.26); C12(0.97); C569(1.37)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C529(0.95)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C1021(1.32)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C1021(1.08)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C12(1.13)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C529(1.02); C1021(1.09)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C529(1.22); C1021(0.92); C550(1.02)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C529(1.05); C1021(0.89)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C1021(0.97); C12(0.94)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C529(1.07); C1021(1.09)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C529(0.84)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C529(1.84); C1021(1.19)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C529(1.15); C1021(1.09)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C404(0.85); C1021(1.29); C12(1.04); C569(0.99)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C1021(1.81)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C1021(1.20)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C12(1.02)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C529(1.15); C1021(1.03)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C529(0.91); C1021(0.86); C550(0.90)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C529(1.06); C1021(0.92)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C529(1.19); C1021(0.88)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C1021(0.94); C12(1.07)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C404(0.98); C1021(1.36); C12(0.98); C569(0.91)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C529(0.71); C1021(0.96)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C529(1.03)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C529(1.07); C1021(1.03)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C404(1.06); C1021(1.25); C12(1.04); C569(0.89)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C1021(1.69)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C1021(1.18)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C12(1.04)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C529(1.13); C1021(0.96)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C529(1.32); C1021(0.96); C550(0.77)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C529(1.05); C1021(1.02)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C529(1.76); C1021(1.08)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C529(1.74); C1021(0.96)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C529(1.18); C1021(0.96); C550(1.09)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C529(0.96)  LDD1492  [6]
 LDCM0023  KB03 Jurkat C1021(4.98); C12(9.12)  LDD0209  [1]
 LDCM0024  KB05 COLO792 C12(4.19)  LDD3310  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) GADD45 family P24522

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840