Details of the Target

General Information of Target

Target ID LDTP03446
Target Name Dual specificity protein phosphatase 1 (DUSP1)
Gene Name DUSP1
Gene ID 1843
Synonyms
CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Nucleus
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
TTD ID
T35194
Uniprot ID
P28562
DrugMap ID
TTG8HIM
Ensemble ID
ENST00000239223.4
HGNC ID
HGNC:3064
ChEMBL ID
CHEMBL6026

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.53  LDD0403  [1]
DBIA
 Probe Info  		C132(0.88); C136(0.88)  LDD0593  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 PaTu 8988t C132(1.52); C136(1.52)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C132(1.28); C136(1.28)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C132(1.24); C136(1.24)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C132(1.45); C136(1.45)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C132(1.46); C136(1.46)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C132(1.82); C136(1.82)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C132(1.44); C136(1.44)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C132(1.69); C136(1.69)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C132(1.26); C136(1.26)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C132(1.84); C136(1.84)  LDD1104  [2]
 LDCM0227  AC110 PaTu 8988t C132(1.65); C136(1.65)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C132(1.29); C136(1.29)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C132(1.46); C136(1.46)  LDD1108  [2]
 LDCM0276  AC17 HCT 116 C132(0.88); C136(0.88)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C132(1.17); C136(1.17)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C132(0.93); C136(0.93)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C132(0.79); C136(0.79)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C132(0.92); C136(0.92)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C132(0.96); C136(0.96)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C132(0.51); C136(0.51)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C132(0.95); C136(0.95)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C132(0.75); C136(0.75)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C132(0.57); C136(0.57)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C132(0.64); C136(0.64)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C132(0.70); C136(0.70)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C132(0.67); C136(0.67)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C132(0.58); C136(0.58)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C132(0.64); C136(0.64)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C132(0.74); C136(0.74)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C132(0.73); C136(0.73)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C132(1.03); C136(1.03)  LDD0612  [2]
 LDCM0296  AC35 PaTu 8988t C132(1.27); C136(1.27)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C132(1.34); C136(1.34)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C132(1.13); C136(1.13)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C132(1.23); C136(1.23)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C132(1.25); C136(1.25)  LDD1179  [2]
 LDCM0302  AC40 PaTu 8988t C132(1.38); C136(1.38)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C132(1.62); C136(1.62)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C132(1.42); C136(1.42)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C132(1.24); C136(1.24)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C132(1.31); C136(1.31)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C132(1.11); C136(1.11)  LDD1186  [2]
 LDCM0308  AC46 HCT 116 C132(0.84); C136(0.84)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C132(0.99); C136(0.99)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C132(1.01); C136(1.01)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C132(0.86); C136(0.86)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C132(0.93); C136(0.93)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C132(0.85); C136(0.85)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C132(1.26); C136(1.26)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C132(1.01); C136(1.01)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C132(0.98); C136(0.98)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C132(1.17); C136(1.17)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C132(1.23); C136(1.23)  LDD0636  [2]
 LDCM0320  AC57 PaTu 8988t C132(2.05); C136(2.05)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C132(1.89); C136(1.89)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C132(2.55); C136(2.55)  LDD1201  [2]
 LDCM0324  AC60 PaTu 8988t C132(1.24); C136(1.24)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C132(1.26); C136(1.26)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C132(1.56); C136(1.56)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C132(1.51); C136(1.51)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C132(1.90); C136(1.90)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C132(1.70); C136(1.70)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C132(2.73); C136(2.73)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C132(1.33); C136(1.33)  LDD1210  [2]
 LDCM0365  AC98 PaTu 8988t C132(1.35); C136(1.35)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C132(1.41); C136(1.41)  LDD1245  [2]
 LDCM0156  Aniline NCI-H1299 10.53  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C132(0.86); C136(0.86)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C132(0.96); C136(0.96)  LDD1247  [2]
 LDCM0374  CL105 HCT 116 C132(0.77); C136(0.77)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C132(0.94); C136(0.94)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C132(0.99); C136(0.99)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C132(1.01); C136(1.01)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C132(0.69); C136(0.69)  LDD0695  [2]
 LDCM0379  CL11 PaTu 8988t C132(1.17); C136(1.17)  LDD1258  [2]
 LDCM0380  CL110 HCT 116 C132(0.72); C136(0.72)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C132(0.76); C136(0.76)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C132(0.62); C136(0.62)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C132(0.70); C136(0.70)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C132(0.63); C136(0.63)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C132(0.62); C136(0.62)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C132(0.60); C136(0.60)  LDD0703  [2]
 LDCM0387  CL117 PaTu 8988t C132(1.03); C136(1.03)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C132(1.10); C136(1.10)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C132(1.21); C136(1.21)  LDD1268  [2]
 LDCM0390  CL12 PaTu 8988t C132(1.52); C136(1.52)  LDD1269  [2]
 LDCM0391  CL120 PaTu 8988t C132(1.28); C136(1.28)  LDD1270  [2]
 LDCM0392  CL121 HCT 116 C132(0.75); C136(0.75)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C132(0.99); C136(0.99)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C132(0.80); C136(0.80)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C132(0.94); C136(0.94)  LDD0712  [2]
 LDCM0396  CL125 PaTu 8988t C132(2.39); C136(2.39)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C132(1.22); C136(1.22)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C132(1.11); C136(1.11)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C132(1.26); C136(1.26)  LDD1278  [2]
 LDCM0400  CL13 PaTu 8988t C132(2.03); C136(2.03)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C132(1.78); C136(1.78)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C132(1.97); C136(1.97)  LDD1281  [2]
 LDCM0407  CL2 PaTu 8988t C132(1.55); C136(1.55)  LDD1286  [2]
 LDCM0418  CL3 PaTu 8988t C132(1.29); C136(1.29)  LDD1297  [2]
 LDCM0429  CL4 PaTu 8988t C132(1.46); C136(1.46)  LDD1308  [2]
 LDCM0436  CL46 HCT 116 C132(0.84); C136(0.84)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C132(0.76); C136(0.76)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C132(1.07); C136(1.07)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C132(1.17); C136(1.17)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C132(1.45); C136(1.45)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C132(0.73); C136(0.73)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C132(1.07); C136(1.07)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C132(0.91); C136(0.91)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C132(0.66); C136(0.66)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C132(0.63); C136(0.63)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C132(1.76); C136(1.76)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C132(0.92); C136(0.92)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C132(0.48); C136(0.48)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C132(1.22); C136(1.22)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C132(0.89); C136(0.89)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C132(1.03); C136(1.03)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C132(0.92); C136(0.92)  LDD0769  [2]
 LDCM0462  CL7 PaTu 8988t C132(1.59); C136(1.59)  LDD1341  [2]
 LDCM0473  CL8 PaTu 8988t C132(1.20); C136(1.20)  LDD1352  [2]
 LDCM0484  CL9 PaTu 8988t C132(1.80); C136(1.80)  LDD1363  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Mitogen-activated protein kinase 3 (MAPK3) CMGC Ser/Thr protein kinase family P27361
S-phase kinase-associated protein 2 (SKP2) . Q13309
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyubiquitin-B (UBB) Ubiquitin family P0CG47

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Avastin+/-tarceva Small molecular drug D0C0NH
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-ethoxynaphthalene-1,2-dione Small molecular drug D07REK
Adociaquinone B Small molecular drug D07FFL
Okadaic Acid Small molecular drug D01SLG

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.