Details of the Target

General Information of Target

Target ID LDTP03340
Target Name Tumor necrosis factor receptor superfamily member 5 (CD40)
Gene Name CD40
Gene ID 958
Synonyms
TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECL
PCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCV
LHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTN
KTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPD
DLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Subcellular location
Secreted; Cell membrane
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
TTD ID
T45758
Uniprot ID
P25942
DrugMap ID
TTN6Y9A
Ensemble ID
ENST00000372276.7
HGNC ID
HGNC:11919
ChEMBL ID
CHEMBL1250358

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE150 SNV: p.P43L .
P31FUJ SNV: p.L209F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C125(1.27)  LDD1700  [1]
IPM
 Probe Info  		C125(8.37); C186(0.46)  LDD1701  [1]
DBIA
 Probe Info  		C161(0.57); C167(0.57)  LDD0533  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C125(0.43)  LDD2095  [1]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C125(0.72)  LDD2130  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C125(1.04)  LDD2117  [1]
 LDCM0216  AC100 HCT 116 C161(0.57); C167(0.57)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C161(0.58); C167(0.58)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C161(0.55); C167(0.55)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C161(0.37); C167(0.37)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C161(0.36); C167(0.36)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C161(0.42); C167(0.42)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C161(0.38); C167(0.38)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C161(0.32); C167(0.37)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C161(0.49); C167(0.46)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C161(0.45); C167(0.41)  LDD0542  [2]
 LDCM0227  AC110 HCT 116 C161(0.50); C167(0.45)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C161(0.44); C167(0.41)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C161(0.37); C167(0.37)  LDD0546  [2]
 LDCM0246  AC128 HCT 116 C161(0.78); C167(0.78)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C161(1.47); C167(1.47)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C161(0.93); C167(0.93)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C161(1.36); C167(1.36)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C161(1.41); C167(1.41)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C161(1.23); C167(1.23)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C161(1.10); C167(1.10)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C161(0.98); C167(0.98)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C161(1.05); C167(1.05)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C161(1.04); C167(1.04)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C161(1.08); C167(1.08)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C161(1.08); C167(1.08)  LDD0575  [2]
 LDCM0260  AC140 HCT 116 C161(1.11); C167(1.11)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C161(1.19); C167(1.19)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C161(1.35); C167(1.35)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C161(1.08); C167(1.08)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C161(0.85); C167(0.85)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C161(1.00); C167(1.00)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C161(0.87); C167(0.87)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C161(0.82); C167(0.82)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C161(0.60); C167(0.60)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C161(0.76); C167(0.76)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C161(1.07); C167(1.07)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C161(1.77); C167(1.77)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C161(0.70); C167(0.70)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C161(0.51); C167(0.51)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C161(0.88); C167(0.88)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C161(0.53); C167(0.53)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C161(0.86); C167(0.86)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C161(0.72); C167(0.72)  LDD2161  [2]
 LDCM0296  AC35 HCT 116 C186(2.34)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C186(3.49)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C186(2.04)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C186(2.75)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C186(2.10)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C186(1.83)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C186(1.97)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C186(2.06)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C186(2.00)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C186(1.70)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C186(1.45)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C186(1.29)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C186(1.23)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C186(2.75)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C186(0.77)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C186(0.93)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C186(3.33)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C186(1.35)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C186(0.99)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C186(0.89)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C186(0.87)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C186(0.86)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C167(0.52); C186(0.77); C161(0.83)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C167(0.52); C161(0.81); C186(1.08)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C167(0.30); C161(0.51); C186(0.61)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C167(0.34); C186(0.61); C161(0.68)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C167(0.62); C186(0.71); C161(0.98)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C167(0.28); C161(0.49); C186(0.81)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C167(0.32); C161(0.59); C186(0.84)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C167(0.29); C161(0.49); C186(0.51)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C167(0.77); C161(1.37); C186(2.29)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C167(0.90); C161(1.44); C186(1.84)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C167(0.40); C186(0.67); C161(0.76)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C186(0.88)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C186(1.17)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C186(0.67)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C186(0.91)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C186(0.70)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C186(0.47)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C186(0.40)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C186(0.36)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C186(0.92)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C186(0.60)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C186(1.32)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C186(1.02)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C186(0.59)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C186(0.46)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C186(0.32)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C161(0.13); C167(0.13)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C161(0.47); C167(0.47)  LDD0683  [2]
 LDCM0545  Acetamide MDA-MB-231 C125(0.74)  LDD2138  [1]
 LDCM0020  ARS-1620 HCC44 C125(1.03)  LDD2171  [2]
 LDCM0498  BS-3668 MDA-MB-231 C125(0.80)  LDD2091  [1]
 LDCM0387  CL117 HCT 116 C186(1.32)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C186(2.20)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C186(1.21)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C186(2.09)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C186(1.41)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C186(1.41)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C186(1.37)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C186(1.18)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C186(1.18); C161(1.93); C167(2.03)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C186(1.68); C161(1.83); C167(1.83)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C167(1.31); C161(1.46); C186(2.80)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C167(0.40); C161(0.69); C186(0.75)  LDD0716  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C125(3.13)  LDD1702  [1]
 LDCM0022  KB02 A2780 C77(1.34); C83(1.40)  LDD2254  [3]
 LDCM0023  KB03 MDA-MB-231 C125(8.37); C186(0.46)  LDD1701  [1]
 LDCM0024  KB05 MEL167 C83(1.53)  LDD3316  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C186(0.43)  LDD2102  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C125(1.13)  LDD2121  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C125(1.01)  LDD2089  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C125(1.09)  LDD2093  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C125(1.01)  LDD2099  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C125(0.82)  LDD2101  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C186(1.05)  LDD2105  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C125(1.08)  LDD2109  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C125(0.86)  LDD2111  [1]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C125(1.02)  LDD2123  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C125(0.90)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C125(1.03)  LDD2127  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C125(0.96)  LDD2129  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C125(0.51)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C125(0.99)  LDD2135  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C125(0.75)  LDD2137  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C125(1.27)  LDD1700  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C125(0.79)  LDD2140  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C125(0.71)  LDD2141  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C125(1.66)  LDD2144  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C125(1.24)  LDD2145  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C125(0.40)  LDD2148  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C125(0.89)  LDD2150  [1]
 LDCM0021  THZ1 HCT 116 C125(1.03)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) . Q8NBI2
TLC domain-containing protein 1 (TLCD1) . Q96CP7
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Proton-coupled zinc antiporter SLC30A2 (SLC30A2) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q9BRI3
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Myelin and lymphocyte protein (MAL) MAL family P21145
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
BOS complex subunit TMEM147 (TMEM147) TMEM147 family Q9BVK8
Zinc transporter ZIP13 (SLC39A13) ZIP transporter (TC 2.A.5) family Q96H72
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) Chemokine-like factor family Q9NX76
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-defensin 121 (DEFB121) Beta-defensin family Q5J5C9
Transmembrane protein 107 (TMEM107) . Q6UX40

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Apx005m Antibody D01ZLK
Askp-1240 Antibody D0G3TJ
Bi 655064 Antibody D0C8NG
Cfz533 . D0SD6V
Phase 1
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cdx-1140 Antibody DKM7S3
Gen1042 Antibody DN28KM
Ng-350a Gene therapy DTM8B0
Sl-172154 Recombinant protein DKUF26
Cp-870,893 Small molecular drug DE0TD1
Abbv-323 . D01NZH
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pg-120 Antibody D0A9BO
Dacetuzumab Monoclonal antibody DB12589
Lucatumumab Monoclonal antibody DB06360
Anti-cd40-xten . D0V3HC
Cd154 . D0Q5GS
Human Cd40 Agonist Ligand . D0SO4M
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hucd40l . D0L4BR
Rhucd40l . D0Y3XB

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840