Details of the Target

General Information of Target

Target ID LDTP02998
Target Name Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Gene Name TNFRSF1A
Gene ID 7132
Synonyms
TNFAR; TNFR1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Subcellular location
Secreted; Cell membrane
Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
TTD ID
T86552
Uniprot ID
P19438
DrugMap ID
TTG043C
Ensemble ID
ENST00000162749.7
HGNC ID
HGNC:11916
ChEMBL ID
CHEMBL3378

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GAMG Insertion: p.R235HfsTer119; p.Y236LfsTer19 .
ICC137 SNV: p.C442W DBIA    Probe Info 
IM95 SNV: p.V424M .
MDST8 SNV: p.K265Ter .
SNU1 SNV: p.A361T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K107(1.07)  LDD3494  [1]
m-APA
 Probe Info  		12.77  LDD0403  [2]
DBIA
 Probe Info  		C44(0.90)  LDD3323  [3]
IPM
 Probe Info  		C248(6.40)  LDD1702  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C248(1.12)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C248(1.03)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C248(0.93); C304(0.99)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C248(1.01); C304(1.05)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C248(0.99); C195(1.17)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C248(1.01)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C248(0.91)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C248(1.01)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C248(1.10); C304(0.91)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C248(1.10)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C248(0.91); C304(1.25)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C248(1.03); C195(1.03)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C248(1.04); C195(0.93)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C248(0.97)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C84(0.77); C248(0.96); C195(0.99); C304(1.22)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C248(0.94)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C248(1.01)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C248(1.00); C304(1.08)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C248(0.96); C304(0.82)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C248(0.92); C195(1.01)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C248(0.88); C304(1.12)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C248(0.92); C195(1.29)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C248(1.12)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C84(0.77); C248(0.94); C195(1.00); C304(1.16)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C248(1.01)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C248(0.98)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C248(0.90); C304(1.08)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C248(0.93); C304(1.16)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C248(0.92); C195(1.16)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C248(0.95); C195(1.18)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C248(1.04)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C248(0.86); C304(1.17)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C84(1.02); C248(1.01); C195(1.01); C304(1.09)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C248(0.94)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C248(0.96)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C248(0.94); C304(1.10)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C248(0.91); C304(0.99)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C248(0.97); C195(1.07)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C248(0.96); C195(1.15)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C248(0.93)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C84(1.16); C248(1.01); C195(1.03); C304(1.01)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C248(0.96)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C248(0.99); C195(1.09)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C248(0.91)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C248(0.94); C304(1.01)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C248(0.91); C304(1.04)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C248(0.99); C195(1.08)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C248(0.92); C195(1.06)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C248(0.89)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C84(1.03); C248(0.97); C195(1.18); C304(0.96)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C248(0.97)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C248(1.02)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C248(0.90); C304(1.08)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C248(1.01); C195(1.21)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C248(0.92); C304(1.08)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C248(0.96); C195(1.03)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C248(0.96); C195(1.08)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C248(0.93)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C84(0.82); C248(0.95); C195(1.02); C304(1.38)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C248(0.93)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C84(1.25); C248(1.02); C195(1.01); C304(0.94)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C248(0.98); C195(1.25)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C248(0.94)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C84(1.16); C248(1.01); C195(1.07); C304(1.50)  LDD1514  [5]
 LDCM0156  Aniline NCI-H1299 12.77  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C248(0.92); C195(1.19)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C248(1.83); C195(1.18)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C248(0.86); C195(0.94); C304(1.13)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C248(0.95); C195(1.15)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C248(0.91)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C248(0.96)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C248(0.87); C195(1.02); C304(1.18)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C248(1.03); C195(0.96)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C248(0.98)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C248(0.97)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C248(0.90); C195(1.07); C304(1.10)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C248(0.92); C195(0.92)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C248(1.35)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C248(0.93)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C248(0.91)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C248(0.91); C195(1.07); C304(1.08)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C248(0.90); C195(1.12)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C248(0.94)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C248(0.81)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C248(0.90); C195(0.93); C304(1.19)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C248(0.99); C195(1.00)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C248(0.93)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C248(0.88)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C84(1.33); C248(1.38); C195(1.14); C304(1.09)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C248(0.87); C195(1.17); C304(1.45)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C248(0.95); C195(0.95)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C248(0.96)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C248(0.85)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C248(0.83); C195(1.15); C304(1.04)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C248(1.00); C195(1.01)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C248(0.97)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C248(0.91)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C248(0.90); C195(1.05); C304(1.22)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C248(0.90); C195(1.15)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C248(0.89)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C248(1.10)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C248(0.76); C195(0.84); C304(1.17)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C248(1.07)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C248(1.08)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C248(0.93); C304(1.87)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C248(1.05)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C248(1.12); C304(1.13)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C248(1.24); C195(1.07)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C248(1.39); C195(1.16)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C248(1.24)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C84(1.11); C248(1.30); C195(1.09); C304(1.15)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C248(0.99); C195(1.25)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C248(0.92)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C248(0.90)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C248(0.88); C195(1.02); C304(0.89)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C248(0.99)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C248(1.08)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C248(0.97)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C248(1.10); C304(0.90)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C248(1.06); C304(1.24)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C248(1.19); C195(0.90)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C248(1.22); C195(1.13)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C248(1.17)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C84(1.42); C248(1.34); C195(1.15); C304(1.12)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C248(0.99); C195(0.97)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C248(0.83)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C248(0.92); C195(0.89); C304(1.05)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C248(0.87); C195(0.89); C304(1.08)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C248(1.00)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C248(0.92)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C248(0.99); C304(1.13)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C248(1.06); C304(1.17)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C248(1.20); C195(1.02)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C248(1.31); C195(1.21)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C248(1.59)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C84(1.68); C248(1.43); C195(1.10); C304(1.68)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C248(0.90); C195(1.02)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C248(1.09)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C248(0.90)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C248(0.89); C195(1.08); C304(1.42)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C248(0.96)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C248(1.08)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C248(0.95); C304(1.04)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C248(0.94); C304(0.76)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C248(1.24); C195(1.03)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C248(1.35); C195(1.43)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C248(1.20)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C248(1.12)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C84(1.78); C248(1.31); C195(1.20); C304(1.00)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C248(0.88); C195(1.21)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C248(0.97)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C248(0.94)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C248(0.81); C195(1.03); C304(1.12)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C248(1.00)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C248(1.05)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C248(1.03); C304(0.99)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C248(0.99); C304(0.92)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C248(1.16); C195(1.22)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C248(1.00); C304(1.03)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C248(1.13); C195(1.12)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C248(1.24)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C84(1.12); C248(1.33); C195(1.26); C304(1.10)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C248(0.86); C195(0.97)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C248(0.88)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C248(0.79); C195(0.99); C304(0.88)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C248(0.82)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C248(1.04)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C248(0.92); C304(1.31)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C248(1.23); C304(1.07)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C248(1.10); C304(1.09)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C248(1.15); C195(0.98)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C248(1.13); C195(1.17)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C248(1.07)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C84(0.79); C248(1.16); C195(0.91); C304(1.14)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C248(0.90); C195(0.98)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C248(1.02)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C248(0.97)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C248(0.88); C195(0.88); C304(1.08)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C248(1.07)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C248(1.28); C195(0.65)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C248(1.33)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C248(0.98); C304(1.24)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C248(1.00); C304(0.86)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C248(1.06); C195(1.09)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C248(1.16); C195(1.04)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C248(1.20)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C84(1.15); C248(1.16); C195(1.10); C304(1.09)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C248(0.96); C195(1.13)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C248(1.00)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C248(0.93)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C248(0.81)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C248(6.40)  LDD1702  [4]
 LDCM0468  Fragment33 HEK-293T C248(0.86)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C248(1.00)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C248(1.03)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C248(1.09)  LDD1497  [5]
 LDCM0024  KB05 SKMEL24 C44(0.90)  LDD3323  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) TKL Ser/Thr protein kinase family Q13546
Riboflavin kinase (RFK) . Q969G6
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) . Q15628

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tasonermin . DB11626
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vb-111 . D0S4LV
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Drug 2862277 Antibody D07LMO
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Avx-470 Antibody D03HIG
Gsk1995057 Antibody D08ENB
Investigative
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ads-0101 Antibody D0G9XS
Anti-tnf Human Mabs Antibody D0X8SM
Nm-9405 Antibody D08TQK
Tnfmab Antibody D0B6WV
6-[3-(4-morpholinyl)Propyl]-2-(3-nitrophenyl)-5-thioxo-56-dihydro-7h-thienol[2'3':45]Pyrrolo[12-c]Imidazol-7-one . DB03507
Alf-421 . D0W7FG
Nm-2014 . D0W0BN
Recombinant Human Tnf Receptor . D0P4WI
Tnfcept . D0U4QQ
Tnfr1 Nam . D03IMU
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-ifn Gamma Antibody D0R4OD

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402