Details of the Target

General Information of Target

Target ID LDTP02907
Target Name NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7)
Gene Name NDUFB7
Gene ID 4713
Synonyms
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Cell adhesion protein SQM1; Complex I-B18; CI-B18; NADH-ubiquinone oxidoreductase B18 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAHLVRRYLGDASVEPDPLQMPTFPPDYGFPERKEREMVATQQEMMDAQLRLQLRDYCA
HHLIRLLKCKRDSFPNFLACKQERHDWDYCEHRDYVMRMKEFERERRLLQRKKRREKKAA
ELAKGQGPGEVDPKVAL
Target Bioclass
Enzyme
Family
Complex I NDUFB7 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot ID
P17568
Ensemble ID
ENST00000215565.3
HGNC ID
HGNC:7702
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C80(2.16)  LDD1701  [1]
DBIA
 Probe Info  		C80(0.98)  LDD0532  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C80(0.00); C90(0.00); C59(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C59(0.00); C80(0.00); C90(0.00)  LDD0037  [3]
NHS
 Probe Info  		N.A.  LDD0010  [4]
TFBX
 Probe Info  		C80(0.00); C59(0.00)  LDD0148  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
NAIA_5
 Probe Info  		C80(0.00); C59(0.00); C90(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C80(0.63)  LDD1093  [2]
 LDCM0215  AC10 HCT 116 C80(0.98)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C80(0.93)  LDD0543  [2]
 LDCM0230  AC113 HEK-293T C80(0.91)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C80(0.76)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C80(0.99)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C80(1.13)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C80(0.82)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C80(0.83)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C80(0.78)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C80(0.94)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C80(0.86)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C80(0.81)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C80(0.70)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C80(0.63)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C80(0.75)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C80(0.62)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C80(0.43)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C80(0.32)  LDD0843  [2]
 LDCM0259  AC14 HCT 116 C80(1.05)  LDD0576  [2]
 LDCM0263  AC143 PaTu 8988t C80(1.02)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C80(1.08)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C80(0.87)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C80(0.89)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C80(0.92)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C80(0.99)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C80(0.81)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C80(1.05)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C80(0.86)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C80(0.50)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C80(0.69)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C80(0.76)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C80(0.76)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C80(0.82)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C80(0.93)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C80(0.83)  LDD2169  [2]
 LDCM0279  AC2 PaTu 8988t C80(0.76)  LDD1158  [2]
 LDCM0281  AC21 HEK-293T C80(0.98)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C90(0.99)  LDD1521  [8]
 LDCM0284  AC24 HEK-293T C80(0.96)  LDD1523  [8]
 LDCM0289  AC29 HEK-293T C80(1.02)  LDD1528  [8]
 LDCM0290  AC3 PaTu 8988t C80(0.60)  LDD1169  [2]
 LDCM0291  AC30 HEK-293T C90(0.98)  LDD1530  [8]
 LDCM0293  AC32 HEK-293T C80(0.99)  LDD1532  [8]
 LDCM0296  AC35 HEK-293T C80(0.90)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C80(0.75)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C80(0.64)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C80(0.86)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C80(0.85)  LDD0898  [2]
 LDCM0301  AC4 PaTu 8988t C80(0.62)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C80(0.75)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C80(0.82)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C80(0.84)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C80(0.79)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C80(0.66)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C80(0.74)  LDD0905  [2]
 LDCM0308  AC46 PaTu 8988t C80(1.11)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C80(1.05)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C80(0.99)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C80(1.05)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C80(0.62)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C80(1.03)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C80(0.93)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C80(1.07)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C80(1.10)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C80(0.90)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C80(0.96)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C80(1.35)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C80(1.02)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C80(1.01)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C80(0.96)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C80(0.88)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C80(1.04)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C80(1.02)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C80(0.99)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C80(1.10)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C80(1.11)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C80(1.12)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C80(0.92)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C80(1.07)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C80(0.96)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C80(1.13)  LDD0931  [2]
 LDCM0334  AC7 HCT 116 C80(1.03)  LDD0651  [2]
 LDCM0335  AC70 HEK-293T C80(1.05)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C80(0.89)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C80(1.11)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C80(0.76)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C80(0.93)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C80(0.79)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C80(1.00)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C80(1.05)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C80(0.91)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C80(1.01)  LDD0942  [2]
 LDCM0345  AC8 HCT 116 C80(1.04)  LDD0662  [2]
 LDCM0346  AC80 HEK-293T C80(1.05)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C80(1.10)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C80(1.15)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C80(1.10)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C80(1.18)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C80(0.92)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C80(1.12)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C80(1.07)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C80(0.95)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C80(1.09)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C80(1.02)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C80(1.20)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C80(1.11)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C80(1.09)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C80(1.30)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C80(1.07)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C80(1.13)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C80(1.16)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C80(1.02)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C80(1.04)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C80(0.88)  LDD0592  [2]
 LDCM0108  Chloroacetamide HeLa C59(0.00); C90(0.00); C80(0.00)  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C80(0.92)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C80(0.85)  LDD0685  [2]
 LDCM0369  CL100 PaTu 8988t C80(0.46)  LDD1248  [2]
 LDCM0370  CL101 HCT 116 C80(1.07)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C80(1.08)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C80(0.86)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C80(0.96)  LDD0690  [2]
 LDCM0379  CL11 HCT 116 C80(0.96)  LDD0696  [2]
 LDCM0387  CL117 HEK-293T C80(0.91)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C80(0.86)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C80(0.70)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C80(0.87)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C80(0.74)  LDD0989  [2]
 LDCM0392  CL121 PaTu 8988t C80(1.24)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C80(1.27)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C80(1.04)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C80(1.25)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C80(1.07)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C80(0.83)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C80(1.04)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C80(1.00)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C80(0.92)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C80(0.94)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C80(0.95)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C80(0.92)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C80(0.87)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C80(0.89)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C80(0.86)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C80(0.88)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C80(0.86)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C80(0.96)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C80(0.51)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C80(0.85)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C80(0.74)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C80(0.72)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C80(0.75)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C80(1.07)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C80(0.80)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C80(0.79)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C80(0.82)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C80(0.79)  LDD0736  [2]
 LDCM0420  CL31 PaTu 8988t C80(1.00)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C80(1.10)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C80(0.92)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C80(1.00)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C80(0.92)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C80(1.36)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C80(0.86)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C80(0.93)  LDD1307  [2]
 LDCM0429  CL4 HCT 116 C80(0.99)  LDD0746  [2]
 LDCM0430  CL40 PaTu 8988t C80(1.17)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C80(1.06)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C80(0.85)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C80(0.32)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C80(1.17)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C80(1.06)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C90(1.06)  LDD1640  [8]
 LDCM0438  CL48 HEK-293T C80(1.13)  LDD1642  [8]
 LDCM0440  CL5 HCT 116 C80(0.92)  LDD0757  [2]
 LDCM0448  CL57 HEK-293T C80(1.00)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C90(0.96)  LDD1652  [8]
 LDCM0451  CL6 HCT 116 C80(0.89)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C80(1.14)  LDD1655  [8]
 LDCM0461  CL69 HEK-293T C80(0.99)  LDD1664  [8]
 LDCM0462  CL7 HCT 116 C80(0.88)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C90(1.02)  LDD1666  [8]
 LDCM0465  CL72 HEK-293T C80(1.06)  LDD1668  [8]
 LDCM0473  CL8 HCT 116 C80(1.05)  LDD0790  [2]
 LDCM0475  CL81 HEK-293T C80(1.06)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C90(1.07)  LDD1679  [8]
 LDCM0478  CL84 HEK-293T C80(1.06)  LDD1681  [8]
 LDCM0484  CL9 HCT 116 C80(0.88)  LDD0801  [2]
 LDCM0486  CL91 PaTu 8988t C80(0.56)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C80(0.49)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C80(0.52)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C80(0.56)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C80(0.50)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C80(0.57)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C80(0.47)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C80(0.59)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C80(0.48)  LDD1373  [2]
 LDCM0427  Fragment51 PaTu 8988t C80(1.01)  LDD1306  [2]
 LDCM0107  IAA HeLa C80(0.00); C59(0.00)  LDD0221  [6]
 LDCM0022  KB02 A2058 C59(1.98)  LDD2253  [9]
 LDCM0023  KB03 MDA-MB-231 C80(2.16)  LDD1701  [1]
 LDCM0024  KB05 COLO792 C59(2.42)  LDD3310  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807
GTP-binding protein GEM (GEM) RGK family P55040
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
NF-kappa-B inhibitor beta (NFKBIB) NF-kappa-B inhibitor family Q15653
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Transcription factor AP-4 (TFAP4) . Q01664
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
Cyclin-C (CCNC) Cyclin family P24863
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Keratin-associated protein 10-10 (KRTAP10-10) KRTAP type 10 family P60014
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Protein ripply1 (RIPPLY1) Ripply family Q0D2K3
Protein ripply2 (RIPPLY2) Ripply family Q5TAB7
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840