Details of the Target

General Information of Target

Target ID LDTP02566
Target Name Fibroblast growth factor receptor 1 (FGFR1)
Gene Name FGFR1
Gene ID 2260
Synonyms
BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; Fibroblast growth factor receptor 1; FGFR-1; EC 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD antigen CD331
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
Subcellular location
Cell membrane
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
TTD ID
T47101
Uniprot ID
P11362
DrugMap ID
TTRLW2X
Ensemble ID
ENST00000326324.10
HGNC ID
HGNC:3688
ChEMBL ID
CHEMBL3650

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.S597F .
HCT116 SNV: p.A343V .
HCT15 SNV: p.A268S .
IM95 SNV: p.I421V .
Ishikawa (Heraklio) 02 ER SNV: p.T79A .
JURKAT SNV: p.A259V .
MCC13 SNV: p.S371L .
MEWO SNV: p.P252S .
NCIH358 SNV: p.R209H .
RKO SNV: p.P150L .
SHP77 SNV: p.E792K .
SUPT1 SNV: p.T26A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C615(2.15)  LDD3376  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C736(0.89); C178(0.89); C603(1.03); C488(1.02)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C736(1.04); C178(0.99); C603(1.08); C488(1.08)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C736(1.07); C178(0.97); C603(0.96); C488(1.12)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C736(1.05); C178(0.96); C488(1.12); C551(1.06)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C736(1.04); C603(0.98); C488(0.97)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C736(1.11); C603(1.08); C488(1.06); C584(1.00)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C736(1.08); C178(1.14); C603(1.03); C488(1.01)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C736(0.98); C178(0.99); C603(1.21); C488(1.13)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C736(1.04); C178(1.24); C603(1.02); C488(1.12)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C736(1.10); C178(1.02); C603(1.10); C488(1.01)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C736(1.00); C178(0.97); C488(1.09); C551(0.99)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C736(0.96); C603(0.93); C488(1.07)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C736(1.03); C603(0.97); C488(0.89)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C736(1.15); C603(1.03); C488(1.09); C584(0.96)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C736(0.99); C178(1.03); C603(0.98); C488(0.92)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C736(1.10); C178(0.83); C603(1.02); C488(1.02)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C736(1.04); C178(1.04); C603(1.09); C488(1.02)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C736(1.08); C178(0.94); C603(0.96); C488(1.10)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C736(1.02); C178(1.10); C488(1.17); C551(0.99)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C736(1.02); C603(0.95); C488(1.11)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C736(1.01); C178(0.99); C603(1.05); C488(1.11)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C736(0.95); C603(1.06); C488(0.99)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C736(1.03); C603(1.07); C488(1.03); C584(1.03)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C736(0.91); C178(1.04); C603(1.01); C488(0.95)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C736(1.14); C178(1.17); C603(1.00); C488(1.03)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C736(1.11); C178(0.92); C603(1.03); C488(1.09)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C736(1.16); C178(0.90); C603(0.94); C488(1.02)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C736(1.07); C178(1.18); C488(1.08); C551(1.03)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C736(1.08); C603(0.89); C488(0.99)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C736(1.06); C603(0.91); C488(1.00)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C736(1.18); C603(0.99); C488(1.05); C584(0.97)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C736(1.07); C178(1.14); C488(1.07); C551(1.04)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C736(1.08); C178(0.86); C603(0.97); C488(0.99)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C736(1.25); C178(1.21); C603(0.99); C488(1.04)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C736(1.14); C178(1.01); C603(1.10); C488(1.02)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C736(1.02); C178(0.94); C603(0.97); C488(1.10)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C736(1.07); C178(1.10); C488(1.08); C551(0.89)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C736(1.02); C603(0.84); C488(0.99)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C736(1.13); C603(1.00); C488(1.11)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C736(1.03); C603(1.03); C488(1.01); C584(1.03)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C736(1.00); C178(0.98); C603(0.96); C488(0.98)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C736(0.99); C178(1.10); C603(0.98); C488(1.10)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C736(1.04); C603(0.91); C488(1.01)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C736(1.10); C178(0.99); C603(1.12); C488(1.07)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C736(1.10); C178(0.93); C603(1.02); C488(1.09)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C736(1.03); C178(1.21); C488(1.08); C551(1.03)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C736(0.92); C603(1.00); C488(1.03)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C736(1.08); C603(1.03); C488(1.08)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C736(1.05); C603(1.05); C488(0.98); C584(0.95)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C736(1.05); C178(0.95); C603(0.98); C488(1.01)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C736(0.97); C178(1.14); C603(0.93); C488(1.03)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C736(1.06); C178(1.04); C603(1.05); C488(1.14)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C736(1.01); C178(0.89); C603(1.01); C488(1.09)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C736(1.03); C603(1.02); C488(1.03)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C736(1.02); C178(1.01); C488(1.16); C551(1.13)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C736(1.03); C603(1.10); C488(1.15)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C736(0.98); C603(1.05); C488(1.03)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C736(1.01); C603(0.99); C488(1.05); C584(0.98)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C736(1.04); C178(0.98); C603(1.00); C488(1.00)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C736(0.98); C603(1.12); C488(1.07); C584(1.06)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C736(0.99); C178(0.96); C603(1.00); C488(1.00)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C736(0.94); C603(0.90); C488(1.03)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C736(1.10); C178(1.01); C603(1.01); C488(1.12)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C736(1.02); C178(0.95); C603(1.06); C488(1.07)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C736(1.09); C178(0.90); C603(0.99); C488(1.35)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C736(1.40); C603(1.12); C488(1.42)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C736(1.06); C178(0.95); C603(1.07); C488(0.86)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C736(1.06); C178(1.03); C603(1.00); C488(1.05)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C736(0.91); C178(0.96); C603(1.06); C488(1.01)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C736(1.08); C178(1.08); C603(0.88); C488(0.91)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C736(1.02); C178(0.90); C603(1.06); C488(1.04)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C736(1.05); C178(0.94); C603(0.98); C488(0.88)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C736(0.96); C178(0.95); C603(0.99); C488(1.00)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C736(1.06); C178(1.00); C603(1.12); C488(0.97)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C736(0.95); C178(1.09); C603(1.02); C488(0.87)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C736(1.04); C178(0.89); C603(1.00); C488(0.94)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C736(1.56); C603(1.14); C488(0.79); C584(1.08)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C736(0.92); C178(1.02); C603(1.21); C488(1.04)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C736(1.01); C178(1.04); C603(0.92); C488(1.02)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C736(0.96); C178(0.90); C603(1.06); C488(0.95)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C736(1.06); C178(0.86); C603(1.01); C488(1.06)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C736(0.96); C178(0.92); C603(1.13); C488(1.06)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C736(1.05); C178(1.03); C603(0.95); C488(0.91)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C736(1.01); C178(1.11); C603(1.03); C488(0.92)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C736(1.05); C178(1.01); C603(1.00); C488(1.02)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C736(0.94); C178(0.93); C603(0.95); C488(1.10)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C736(1.02); C178(0.97); C603(0.72); C488(0.92)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C736(1.11); C178(0.93); C603(1.06); C488(1.26)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C736(1.02); C178(0.94); C603(0.98); C488(0.93)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C736(1.03); C178(0.97); C603(0.97); C488(1.05)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C736(0.87); C178(0.93); C603(0.95); C488(1.06)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C736(1.07); C178(1.19); C603(1.14); C488(0.88)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C736(1.05); C178(1.13); C603(1.16); C488(1.01)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C736(0.99); C178(0.87); C603(0.93); C488(0.99)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C736(0.91); C178(0.95); C603(1.02); C488(1.08)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C736(1.01); C178(1.04); C603(0.85); C488(1.01)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C736(0.96); C178(0.86); C603(1.05); C488(0.97)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C736(1.11); C178(1.02); C603(1.03); C488(1.23)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C736(1.01); C178(0.82); C603(0.95); C488(1.00)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C736(1.12); C178(1.09); C603(1.06); C488(1.17)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C736(1.00); C178(0.90); C603(1.15); C488(1.13)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C736(1.03); C178(1.15); C603(0.92); C488(1.44)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C736(1.16); C178(0.96); C603(0.96); C488(1.06)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C736(1.25); C178(0.93); C603(0.99); C488(1.19)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C736(1.01); C178(0.83); C603(0.89); C488(0.92)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C736(1.18); C178(0.91); C488(0.97); C551(1.15)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C736(1.50); C603(0.90); C488(0.57)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C736(1.35); C603(0.87); C488(1.35)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C736(1.73); C603(0.94); C488(0.66); C584(1.15)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C736(1.07); C178(0.93); C603(1.00); C488(1.37)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C736(1.06); C178(1.08); C603(1.08); C488(1.05)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C736(1.01); C178(0.98); C603(0.96); C488(0.90)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C736(1.09); C178(0.95); C603(1.09); C488(0.92)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C736(0.99); C178(1.15); C603(1.06); C488(0.99)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C736(1.06); C178(1.01); C603(0.97); C488(1.22)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C736(1.16); C178(0.94); C603(1.01); C488(1.04)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C736(1.09); C178(1.02); C603(1.02); C488(1.03)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C736(1.31); C178(1.00); C603(1.10); C488(0.95)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C736(1.08); C178(0.93); C488(0.92); C551(1.14)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C736(1.49); C603(1.02); C488(0.62)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C736(1.22); C603(0.97); C488(1.31)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C736(1.42); C603(1.04); C488(0.60); C584(1.11)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C736(1.13); C178(0.98); C603(0.95); C488(1.49)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C736(1.05); C178(1.02); C603(1.03); C488(0.97)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C736(1.10); C178(1.01); C603(1.06); C488(1.05)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C736(1.11); C178(0.97); C603(1.00); C488(1.01)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C736(0.99); C178(0.90); C603(0.99); C488(1.04)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C736(1.13); C178(1.01); C603(1.10); C488(1.01)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C736(1.05); C178(0.91); C603(1.00); C488(0.90)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C736(1.27); C178(0.96); C603(1.10); C488(0.97)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C736(1.00); C178(0.87); C488(0.99); C551(1.19)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C736(1.38); C603(1.15); C488(0.56)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C736(1.27); C603(1.02); C488(1.33)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C736(1.56); C603(1.05); C488(0.65); C584(1.17)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C736(1.11); C178(0.98); C603(1.03); C488(1.55)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C736(1.12); C178(0.84); C603(1.00); C488(0.96)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C736(1.14); C178(1.13); C603(0.99); C488(1.09)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C736(1.11); C178(0.88); C603(1.02); C488(1.00)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C736(1.05); C178(0.82); C603(1.05); C488(0.96)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C736(1.21); C178(0.99); C603(1.01); C488(1.11)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C736(1.16); C178(0.97); C603(1.10); C488(0.90)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C736(1.32); C178(0.86); C603(1.05); C488(1.06)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C736(1.10); C178(1.06); C488(0.89); C551(1.10)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C736(1.41); C603(0.97); C488(0.60)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C736(1.32); C603(1.14); C488(1.14)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C736(1.76); C603(1.03); C488(0.66); C584(1.09)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C736(1.20); C178(0.96); C603(1.21); C488(0.97)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C736(1.06); C178(0.92); C603(0.98); C488(1.26)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C736(1.05); C178(0.91); C603(1.06); C488(1.12)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C736(0.97); C178(0.88); C603(1.13); C488(1.02)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C736(1.10); C178(1.00); C603(0.94); C488(0.93)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C736(1.03); C178(0.93); C603(1.07); C488(0.89)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C736(1.11); C178(1.18); C603(0.92); C488(1.03)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C736(1.14); C178(1.06); C603(1.10); C488(0.96)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C736(1.18); C178(0.94); C603(0.94); C488(1.03)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C736(1.08); C178(1.36); C488(0.93); C551(1.13)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C736(1.25); C603(0.77); C488(0.63)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C736(1.27); C178(0.92); C603(1.00); C488(1.10)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C736(1.41); C603(0.96); C488(1.23)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C736(1.61); C603(1.10); C488(0.70); C584(1.02)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C736(1.02); C178(1.01); C603(1.09); C488(1.20)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C736(1.07); C178(1.02); C603(0.98); C488(1.23)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C736(0.83); C178(0.89); C603(0.97); C488(0.83)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C736(1.01); C178(1.01); C603(1.02); C488(0.98)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C736(1.16); C178(1.11); C603(1.19); C488(1.07)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C736(1.12); C178(0.96); C603(0.99); C488(0.97)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C736(1.22); C178(0.94); C603(1.01); C488(1.05)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C736(1.23); C178(1.45); C488(1.13); C551(1.44)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C736(1.13); C178(0.92); C488(0.92); C551(1.11)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C736(1.46); C603(0.95); C488(0.66)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C736(1.27); C603(0.96); C488(1.24)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C736(1.31); C603(1.06); C488(0.83); C584(1.05)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C736(1.06); C178(1.02); C603(1.00); C488(1.36)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C736(1.00); C178(0.94); C603(1.03); C488(0.96)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C736(0.87); C178(0.91); C603(1.13); C488(1.03)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C736(1.03); C178(1.11); C603(1.23); C488(1.08)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C736(1.02); C178(0.87); C603(1.16); C488(0.89)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C736(1.01); C178(0.99); C603(1.02); C488(1.02)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C736(1.44); C603(0.93); C488(0.61)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C736(1.23); C178(1.20); C603(1.22); C488(1.50)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C736(1.11); C178(1.05); C603(1.10); C488(1.11)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C736(1.04); C178(1.07); C488(1.01); C551(1.17)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C736(1.22); C603(0.99); C488(0.79)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C736(1.16); C603(1.08); C488(1.26)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C736(1.34); C603(1.18); C488(1.04); C584(1.03)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C736(1.02); C178(0.94); C603(1.15); C488(1.22)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C736(1.02); C178(0.96); C603(1.01); C488(1.04)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C736(0.98); C178(0.94); C603(1.01); C488(0.98)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C736(1.00); C178(1.10); C603(0.95); C488(0.88)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C736(1.09); C178(1.09); C603(1.08); C488(0.95)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C736(1.10); C178(1.14); C603(1.05); C488(0.96)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C736(1.02); C178(0.93); C603(1.07); C488(0.91)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C178(0.90); C584(0.94); C488(0.99); C603(1.14)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C178(1.06); C584(0.99); C488(1.09); C603(1.04)  LDD1497  [4]
 LDCM0024  KB05 ONS-76 C615(2.15)  LDD3376  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 1 (FGFR1) Tyr protein kinase family P11362
Fibroblast growth factor receptor 2 (FGFR2) Tyr protein kinase family P21802
Fibroblast growth factor receptor 4 (FGFR4) Tyr protein kinase family P22455
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
E3 ubiquitin-protein ligase NEDD4 (NEDD4) . P46934
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Fibroblast growth factor 2 (FGF2) Heparin-binding growth factors family P09038
Fibroblast growth factor 23 (FGF23) Heparin-binding growth factors family Q9GZV9
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxytryptamine receptor 1A (HTR1A) G-protein coupled receptor 1 family P08908
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Fibroblast growth factor 1 (FGF1) Heparin-binding growth factors family P05230
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Anosmin-1 (ANOS1) . P23352
Fibroblast growth factor receptor substrate 2 (FRS2) . Q8WU20
Nostrin (NOSTRIN) . Q8IVI9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 17 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Palifermin BiotechDrug DB00039
Fostamatinib Small molecular drug DB12010
Heparin Small molecular drug DB01109
Infigratinib Small molecular drug DB11886
Intedanib Small molecular drug D09HNV
Lenvatinib Small molecular drug DB09078
Nintedanib Small molecular drug DB09079
Ponatinib Small molecular drug DB08901
Regorafenib Small molecular drug DB08896
Romiplostim Small molecular drug D01PZD
Sorafenib Small molecular drug DB00398
Tivozanib Small molecular drug DB11800
Erdafitinib . DB12147
Futibatinib . DB15149
Pemigatinib . D0O6UY
Pralsetinib . DB15822
Selpercatinib . DB15685
Phase 3
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rosiglitazone + Metformin Combination drug (small molecular drug) D0A1AQ
Azd4547 Small molecular drug D0NU0U
Bgj398 Small molecular drug D03LWG
E-3810 Small molecular drug D02WVT
Arq-087 . D07PQJ
Sulfatinib . D05PWX
Phase 2
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mk-2461 Small molecular drug D00DRL
Am-001 . D08DFF
Debio 1347 . D0XT0W
Fgf-1 . D08ZHL
Fp-1039 . D0U2DO
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Kw-2449 Small molecular drug D00ABO
Ngm313 . D0DJ0S
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-695735 Small molecular drug D0LF0O
Investigative
Click To Hide/Show 24 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-fgfr1 Mab Program Antibody D00JZS
2-(1h-indazol-3-yl)-1h-benzo[D]Imidazole Small molecular drug D0XC6G
3-(3-methoxybenzyl)-1h-pyrrolo[2,3-b]Pyridine Small molecular drug D06QUJ
3-(3-methoxybenzyl)-1h-pyrrolo[23-b]Pyridine Small molecular drug DB07525
3-benzimidazol-2-ylhydroquinolin-2-one Small molecular drug D07QMC
3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)Methylene]-2-indolinone Small molecular drug DB08577
Aal-993 Small molecular drug D0EE6A
Hki-9924129 Small molecular drug D0D5EW
Np-506 Small molecular drug D04FNY
Pd-0166326 Small molecular drug D0P3JW
Pd-0173952 Small molecular drug D0S1KJ
Pd-0173955 Small molecular drug D03NPX
Pd-0173956 Small molecular drug D0GW4Q
Pd-0173958 Small molecular drug D0Z7GH
Pd-0179483 Small molecular drug D0OH3J
Pmid22765894c8h Small molecular drug D0C2GE
Pmid24900538c2c Small molecular drug D0E7VO
Pmid26080733c7r Small molecular drug D06FFZ
Ro-4396686 Small molecular drug D09XIL
(E)-[4-(35-difluorophenyl)-3h-pyrrolo[23-b]Pyridin-3-ylidene](3-methoxyphenyl)Methanol . DB07840
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone . DB02058
Actb-1003 . D0R6OM
Sar-106881 . D01AVF
Xl999 . DB05014
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pd-0183812 Small molecular drug D0Z0KD

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402