Details of the Target

General Information of Target

Target ID LDTP01962
Target Name Transthyretin (TTR)
Gene Name TTR
Gene ID 7276
Synonyms
PALB; Transthyretin; ATTR; Prealbumin; TBPA
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
Target Type
Successful
Target Bioclass
Enzyme
Family
Transthyretin family
Subcellular location
Secreted
Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TTD ID
T23389
Uniprot ID
P02766
DrugMap ID
TTC1I86
Ensemble ID
ENST00000237014.8
HGNC ID
HGNC:12405
ChEMBL ID
CHEMBL3194

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C30(0.73)  LDD3314  [1]
BTD
 Probe Info  		C30(1.00)  LDD2089  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C30(0.89)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C30(0.85)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C30(0.63)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C30(0.55)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C30(0.71)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C30(0.80)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C30(0.72)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C30(0.81)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C30(0.57)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C30(0.41)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C30(0.77)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C30(0.67)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C30(0.82)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C30(0.76)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C30(0.67)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C30(0.88)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C30(0.82)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C30(0.62)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C30(0.71)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C30(0.67)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C30(0.87)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C30(0.65)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C30(0.71)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C30(0.61)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C30(0.83)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C30(0.89)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C30(0.70)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C30(0.60)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C30(0.74)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C30(0.98)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C30(0.76)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C30(0.71)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C30(0.69)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C30(0.90)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C30(0.87)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C30(0.66)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C30(0.72)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C30(0.65)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C30(0.87)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C30(0.73)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C30(0.66)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C30(0.76)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C30(0.81)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C30(0.86)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C30(0.61)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C30(0.63)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C30(0.68)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C30(0.85)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C30(0.68)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C30(0.64)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C30(0.81)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C30(0.71)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C30(0.57)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C30(0.53)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C30(0.72)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C30(0.77)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C30(0.70)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C30(0.71)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C30(0.74)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C30(0.76)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C30(0.76)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C30(0.85)  LDD1569  [5]
 LDCM0545  Acetamide MDA-MB-231 C30(1.30)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C30(0.83)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C30(0.81)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C30(0.77)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C30(0.69)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C30(0.80)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C30(0.72)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C30(0.74)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C30(0.74)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C30(0.72)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C30(0.65)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C30(0.83)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C30(0.72)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C30(0.68)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C30(0.60)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C30(0.83)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C30(0.62)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C30(0.71)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C30(0.74)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C30(0.66)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C30(0.87)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C30(0.74)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C30(0.69)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C30(0.68)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C30(0.76)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C30(0.69)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C30(0.64)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C30(0.80)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C30(0.69)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C30(0.78)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C30(0.69)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C30(0.62)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C30(0.62)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C30(0.70)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C30(0.49)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C30(0.40)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C30(0.65)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C30(0.65)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C30(0.54)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C30(0.47)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C30(0.62)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C30(0.71)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C30(0.55)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C30(0.52)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C30(0.58)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C30(0.60)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C30(0.75)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C30(0.76)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C30(0.70)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C30(0.72)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C30(0.58)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C30(0.65)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C30(0.53)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C30(0.59)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C30(0.70)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C30(0.50)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C30(0.50)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C30(0.38)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C30(0.54)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C30(0.65)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C30(0.69)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C30(0.68)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C30(0.82)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C30(0.59)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C30(0.55)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C30(0.58)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C30(0.65)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C30(0.75)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C30(0.49)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C30(0.61)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C30(0.59)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C30(0.67)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C30(0.76)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C30(0.78)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C30(0.94)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C30(0.55)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C30(0.59)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C30(0.59)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C30(0.72)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C30(0.78)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C30(0.57)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C30(0.55)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C30(0.62)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C30(0.77)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C30(0.77)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C30(0.74)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C30(0.49)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C30(0.92)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C30(0.56)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C30(0.64)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C30(0.47)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C30(0.72)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C30(0.70)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C30(0.52)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C30(0.48)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C30(0.59)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C30(0.66)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C30(0.33)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C30(0.78)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C30(0.62)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C30(0.81)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C30(0.60)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C30(0.50)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C30(0.62)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C30(0.62)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C30(0.56)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C30(0.48)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C30(0.46)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C30(0.53)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C30(0.68)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C30(0.73)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C30(0.57)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C30(0.71)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C30(0.64)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C30(0.37)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C30(0.28)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C30(0.54)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C30(0.48)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C30(0.67)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C30(0.46)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C30(0.26)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C30(0.50)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C30(0.58)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C30(0.72)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C30(0.48)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C30(0.64)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C30(0.72)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C30(0.80)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C30(0.70)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C30(0.54)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C30(1.06)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C30(0.47)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C30(0.62)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C30(0.87)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C30(0.95)  LDD1497  [5]
 LDCM0024  KB05 IGR37 C30(0.73)  LDD3314  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C30(1.00)  LDD2089  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C30(0.47)  LDD2100  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C30(0.61)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5) Complex I NDUFA5 subunit family Q16718
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
Protein prune homolog 2 (PRUNE2) PPase class C family Q8WUY3
Ribose-phosphate pyrophosphokinase 2 (PRPS2) Ribose-phosphate pyrophosphokinase family P11908
3-ketodihydrosphingosine reductase (KDSR) Short-chain dehydrogenases/reductases (SDR) family Q06136
Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2) Sulfatase-modifying factor family Q8NBJ7
Kinesin-like protein KIF1A (KIF1A) Kinesin family Q12756
Transthyretin (TTR) Transthyretin family P02766
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
E3 ubiquitin-protein ligase UBR1 (UBR1) UBR1 family Q8IWV7
G/T mismatch-specific thymine DNA glycosylase (TDG) TDG/mug family Q13569
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Ubiquitin-like protein 3 (UBL3) . O95164
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1) ATPase alpha/beta chains family P15313
Retinol-binding protein 4 (RBP4) Lipocalin family P02753
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Nucleoporin Nup43 (NUP43) . Q8NFH3
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) BZIP family Q9Y2D1
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Zinc finger protein ZXDC (ZXDC) ZXD family Q2QGD7
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 141 (GPR141) G-protein coupled receptor 1 family Q7Z602
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Advanced glycosylation end product-specific receptor (AGER) . Q15109
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Conserved oligomeric Golgi complex subunit 8 (COG8) COG8 family Q96MW5
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) HesB/IscA family Q86U28
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Protein PALS1 (PALS1) MAGUK family Q8N3R9
Metallothionein-3 (MT3) Type 1 family P25713
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
C-type lectin domain family 11 member A (CLEC11A) . Q9Y240
Cell cycle and apoptosis regulator protein 2 (CCAR2) . Q8N163
Kelch-like protein 20 (KLHL20) . Q9Y2M5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Diclofenac Small molecular drug DB00586
Diethylstilbestrol Small molecular drug DB00255
Diflunisal Small molecular drug DB00861
Flufenamic Acid Small molecular drug DB02266
Levothyroxine Small molecular drug DB00451
Liothyronine Small molecular drug DB00279
Liotrix Small molecular drug DB01583
Patisiran siRNA drug D02UYB
Copper . DB09130
Dimethyl Sulfoxide . DB01093
Tafamidis . DB11644
Thyroid Porcine . DB09100
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis-ttr Antisense drug D0Y9HW
Vutrisiran Small interfering RNA DXRP68
Revusiran siRNA drug D01ZHB
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aln-ttr01 Antisense oligonucleotide DJ0E7P
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-hydroxy-35-diiodobenzoic Acid Small molecular drug DB04674
8-anilinonaphthalene-1-sulfonic Acid Small molecular drug DB04474
Genistein Small molecular drug DB01645
Resveratrol Small molecular drug DB02709
33'55'-tetrachlorobiphenyl-44'-diol . DB03346
Nrp409 . DB05235

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402