Details of the Target

General Information of Target

Target ID LDTP01801
Target Name Complement factor B (CFB)
Gene Name CFB
Gene ID 629
Synonyms
BF; BFD; Complement factor B; EC 3.4.21.47; C3/C5 convertase; Glycine-rich beta glycoprotein; GBG; PBF2; Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEY
VCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPY
YNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQ
YRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTE
TIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKV
ASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQ
AVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRE
DYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGM
VWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVS
VGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCT
EGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDA
QYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWG
VVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
Target Type
Successful
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
TTD ID
T66011
Uniprot ID
P00751
DrugMap ID
TT3SGK7
Ensemble ID
ENST00000399981.5
HGNC ID
HGNC:1037
ChEMBL ID
CHEMBL5731

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.I101T .
HT3 SNV: p.D185N .
MFE319 SNV: p.L273P .
MOLT4 SNV: p.R415H .
NCIH196 SNV: p.P68S .
SBC5 SNV: p.P13H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C145(2.67)  LDD3323  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C725(2.39)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C725(1.23)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C725(0.90)  LDD0824  [3]
 LDCM0230  AC113 HEK-293T C725(1.02)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C725(1.07)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C725(1.02)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C725(0.96)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C725(1.11)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C725(1.18)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C725(1.08)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C725(1.19)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C725(1.10)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C725(1.31)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C725(1.31)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C725(1.28)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C725(1.05)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C725(1.19)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C725(1.42)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C725(1.56)  LDD0843  [3]
 LDCM0246  AC128 PaTu 8988t C725(1.33)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C725(1.11)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C725(0.99)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C725(1.13)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C725(0.95)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C725(1.23)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C725(1.15)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C725(1.15)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C725(1.19)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C725(1.12)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C725(1.01)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C725(1.34)  LDD1137  [3]
 LDCM0259  AC14 HEK-293T C725(1.34)  LDD0857  [3]
 LDCM0260  AC140 PaTu 8988t C725(1.09)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C725(0.95)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C725(1.17)  LDD1141  [3]
 LDCM0270  AC15 HEK-293T C725(1.25)  LDD0868  [3]
 LDCM0276  AC17 PaTu 8988t C725(0.80)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C725(1.05)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C725(0.92)  LDD1157  [3]
 LDCM0279  AC2 HEK-293T C725(1.17)  LDD0877  [3]
 LDCM0280  AC20 PaTu 8988t C725(1.32)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C725(1.06)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C725(1.49)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C725(1.00)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C725(0.95)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C725(0.65)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C725(0.71)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C725(0.59)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C725(1.05)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C725(0.75)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C725(1.09)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C725(0.94)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C725(0.57)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C725(0.60)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C725(0.73)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C725(0.69)  LDD0893  [3]
 LDCM0296  AC35 PaTu 8988t C725(1.05)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C725(1.06)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C725(1.16)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C725(1.41)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C725(1.04)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C725(1.34)  LDD0899  [3]
 LDCM0302  AC40 PaTu 8988t C725(1.08)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C725(0.80)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C725(0.98)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C725(1.11)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C725(1.48)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C725(1.21)  LDD1186  [3]
 LDCM0308  AC46 HEK-293T C725(0.96)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C725(1.20)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C725(1.11)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C725(1.07)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C725(1.26)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C725(1.23)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C725(1.18)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C725(1.05)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C725(0.95)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C725(1.05)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C725(1.24)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C725(0.96)  LDD0917  [3]
 LDCM0320  AC57 PaTu 8988t C725(1.18)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C725(1.13)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C725(1.04)  LDD1201  [3]
 LDCM0323  AC6 HEK-293T C725(0.96)  LDD0921  [3]
 LDCM0324  AC60 PaTu 8988t C725(1.19)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C725(1.10)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C725(1.09)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C725(1.18)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C725(1.23)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C725(0.99)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C725(1.14)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C725(1.39)  LDD1210  [3]
 LDCM0334  AC7 HEK-293T C725(0.91)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C725(0.97)  LDD0943  [3]
 LDCM0349  AC83 HEK-293T C725(0.86)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C725(0.87)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C725(0.84)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C725(0.79)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C725(0.85)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C725(0.79)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C725(1.00)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C725(0.94)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C725(0.87)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C725(0.90)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C725(0.95)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C725(0.90)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C725(0.84)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C725(0.97)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C725(1.25)  LDD0962  [3]
 LDCM0248  AKOS034007472 HEK-293T C725(1.18)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C725(1.06)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C725(1.15)  LDD0873  [3]
 LDCM0367  CL1 HEK-293T C725(0.74)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C725(1.37)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C725(1.40)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C725(0.89)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C725(1.01)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C725(1.16)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C725(1.32)  LDD0971  [3]
 LDCM0374  CL105 PaTu 8988t C725(1.06)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C725(0.80)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C725(0.90)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C725(1.04)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C725(0.97)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C725(1.32)  LDD0977  [3]
 LDCM0380  CL110 PaTu 8988t C725(0.95)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C725(1.56)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C725(0.65)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C725(0.64)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C725(0.73)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C725(0.62)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C725(0.72)  LDD0984  [3]
 LDCM0387  CL117 PaTu 8988t C725(0.77)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C725(1.02)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C725(1.09)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C725(0.71)  LDD0988  [3]
 LDCM0391  CL120 PaTu 8988t C725(0.97)  LDD1270  [3]
 LDCM0392  CL121 HEK-293T C725(1.02)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C725(1.04)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C725(1.00)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C725(0.97)  LDD0993  [3]
 LDCM0396  CL125 PaTu 8988t C725(1.13)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C725(1.03)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C725(0.94)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C725(1.00)  LDD1278  [3]
 LDCM0400  CL13 HEK-293T C725(1.01)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C725(0.82)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C725(0.89)  LDD1000  [3]
 LDCM0403  CL16 PaTu 8988t C725(1.01)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C725(1.21)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C725(1.37)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C725(1.42)  LDD1285  [3]
 LDCM0407  CL2 HEK-293T C725(0.89)  LDD1005  [3]
 LDCM0408  CL20 PaTu 8988t C725(1.37)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C725(1.04)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C725(1.16)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C725(1.38)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C725(1.38)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C725(1.16)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C725(1.21)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C725(1.34)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C725(1.43)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C725(1.37)  LDD1296  [3]
 LDCM0418  CL3 HEK-293T C725(0.86)  LDD1016  [3]
 LDCM0419  CL30 PaTu 8988t C725(1.26)  LDD1298  [3]
 LDCM0429  CL4 HEK-293T C725(0.78)  LDD1027  [3]
 LDCM0436  CL46 HEK-293T C725(1.25)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C725(1.24)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C725(0.96)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C725(1.05)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C725(0.83)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C725(1.57)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C725(1.04)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C725(0.96)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C725(1.18)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C725(1.35)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C725(1.28)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C725(1.45)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C725(1.55)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C725(1.59)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C725(1.41)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C725(1.14)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C725(1.50)  LDD1050  [3]
 LDCM0453  CL61 PaTu 8988t C725(0.92)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C725(0.85)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C725(0.88)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C725(0.96)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C725(1.02)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C725(1.05)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C725(0.96)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C725(1.01)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C725(1.11)  LDD1340  [3]
 LDCM0462  CL7 HEK-293T C725(1.04)  LDD1060  [3]
 LDCM0463  CL70 PaTu 8988t C725(0.95)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C725(0.80)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C725(0.91)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C725(1.02)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C725(0.95)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C725(0.84)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C725(1.01)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C725(1.11)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C725(1.41)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C725(1.30)  LDD1071  [3]
 LDCM0474  CL80 PaTu 8988t C725(1.23)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C725(1.17)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C725(1.13)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C725(1.48)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C725(0.94)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C725(0.94)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C725(1.11)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C725(1.04)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C725(1.21)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C725(0.96)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C725(1.05)  LDD1082  [3]
 LDCM0485  CL90 PaTu 8988t C725(0.87)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C725(0.92)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C725(1.10)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C725(0.93)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C725(1.27)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C725(1.08)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C725(1.26)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C725(0.93)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C725(1.16)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C725(1.18)  LDD1092  [3]
 LDCM0468  Fragment33 PaTu 8988t C725(1.00)  LDD1347  [3]
 LDCM0022  KB02 BRX211 C191(2.23); C62(2.34); C615(3.94); C145(2.42)  LDD2268  [2]
 LDCM0023  KB03 BRX211 C191(2.88); C62(2.91); C615(6.46); C145(3.69)  LDD2685  [2]
 LDCM0024  KB05 SKMEL24 C145(2.67)  LDD3323  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complement C3 (C3) . P01024

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc . DB01593
Zinc Acetate . DB14487
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ionis-fb-lrx Antisense oligonucleotide DQ2Y7L
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Diisopropylphosphono Group Small molecular drug DB04491
4-guanidinobenzoic Acid . DB02459
Mln2222 . DB06503

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.