Details of the Target
General Information of Target
Target ID | LDTP01405 | |||||
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Target Name | Decapping and exoribonuclease protein (DXO) | |||||
Gene Name | DXO | |||||
Gene ID | 1797 | |||||
Synonyms |
DOM3L; DOM3Z; NG6; Decapping and exoribonuclease protein; DXO; EC 3.6.1.-; 5'-3' exoribonuclease DXO; EC 3.1.13.-; Dom-3 homolog Z; NAD-capped RNA hydrolase DXO; DeNADding enzyme DXO; EC 3.6.1.- |
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3D Structure | ||||||
Sequence |
MDPRGTKRGAEKTEVAEPRNKLPRPAPSLPTDPALYSGPFPFYRRPSELGCFSLDAQRQY
HGDARALRYYSPPPTNGPGPNFDLRDGYPDRYQPRDEEVQERLDHLLCWLLEHRGRLEGG PGWLAEAIVTWRGHLTKLLTTPYERQEGWQLAASRFQGTLYLSEVETPNARAQRLARPPL LRELMYMGYKFEQYMCADKPGSSPDPSGEVNTNVAFCSVLRSRLGSHPLLFSGEVDCTDP QAPSTQPPTCYVELKTSKEMHSPGQWRSFYRHKLLKWWAQSFLPGVPNVVAGFRNPDGFV SSLKTFPTMKMFEYVRNDRDGWNPSVCMNFCAAFLSFAQSTVVQDDPRLVHLFSWEPGGP VTVSVHQDAPYAFLPIWYVEAMTQDLPSPPKTPSPK |
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Target Bioclass |
Enzyme
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Family |
DXO/Dom3Z family
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Subcellular location |
Nucleus
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Function |
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to environmental stress. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA. Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Exhibits decapping activity towards FAD-capped RNAs. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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Probe 1 Probe Info |
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Y314(107.65) | LDD3495 | [1] | |
DBIA Probe Info |
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C108(0.92) | LDD3351 | [2] | |
IA-alkyne Probe Info |
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N.A. | LDD0036 | [3] | |
NAIA_5 Probe Info |
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C108(0.00); C51(0.00) | LDD2223 | [4] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C108(1.04) | LDD1507 | [5] |
LDCM0215 | AC10 | PaTu 8988t | C108(0.78) | LDD1094 | [6] |
LDCM0226 | AC11 | PaTu 8988t | C108(0.79) | LDD1105 | [6] |
LDCM0237 | AC12 | PaTu 8988t | C108(0.84) | LDD1116 | [6] |
LDCM0259 | AC14 | PaTu 8988t | C108(1.03) | LDD1138 | [6] |
LDCM0270 | AC15 | PaTu 8988t | C108(0.83) | LDD1149 | [6] |
LDCM0276 | AC17 | HEK-293T | C108(0.91) | LDD1515 | [5] |
LDCM0277 | AC18 | HEK-293T | C108(0.97) | LDD1516 | [5] |
LDCM0278 | AC19 | HEK-293T | C108(0.55) | LDD1517 | [5] |
LDCM0279 | AC2 | HEK-293T | C108(0.89) | LDD1518 | [5] |
LDCM0280 | AC20 | HEK-293T | C108(1.14) | LDD1519 | [5] |
LDCM0281 | AC21 | HEK-293T | C108(0.91) | LDD1520 | [5] |
LDCM0282 | AC22 | HEK-293T | C108(1.11) | LDD1521 | [5] |
LDCM0283 | AC23 | HEK-293T | C108(1.00) | LDD1522 | [5] |
LDCM0284 | AC24 | HEK-293T | C108(0.86) | LDD1523 | [5] |
LDCM0285 | AC25 | HEK-293T | C108(0.93) | LDD1524 | [5] |
LDCM0286 | AC26 | HEK-293T | C108(1.15) | LDD1525 | [5] |
LDCM0287 | AC27 | HEK-293T | C108(1.01) | LDD1526 | [5] |
LDCM0288 | AC28 | HEK-293T | C108(1.11) | LDD1527 | [5] |
LDCM0289 | AC29 | HEK-293T | C108(0.83) | LDD1528 | [5] |
LDCM0290 | AC3 | HEK-293T | C108(1.04) | LDD1529 | [5] |
LDCM0291 | AC30 | HEK-293T | C108(0.86) | LDD1530 | [5] |
LDCM0292 | AC31 | HEK-293T | C108(1.13) | LDD1531 | [5] |
LDCM0293 | AC32 | HEK-293T | C108(0.99) | LDD1532 | [5] |
LDCM0294 | AC33 | HEK-293T | C108(0.94) | LDD1533 | [5] |
LDCM0295 | AC34 | HEK-293T | C108(0.90) | LDD1534 | [5] |
LDCM0296 | AC35 | HEK-293T | C108(1.17) | LDD1535 | [5] |
LDCM0297 | AC36 | HEK-293T | C108(1.00) | LDD1536 | [5] |
LDCM0298 | AC37 | HEK-293T | C108(0.91) | LDD1537 | [5] |
LDCM0299 | AC38 | HEK-293T | C108(1.06) | LDD1538 | [5] |
LDCM0300 | AC39 | HEK-293T | C108(1.21) | LDD1539 | [5] |
LDCM0301 | AC4 | HEK-293T | C108(1.05) | LDD1540 | [5] |
LDCM0302 | AC40 | HEK-293T | C108(1.11) | LDD1541 | [5] |
LDCM0303 | AC41 | HEK-293T | C108(1.02) | LDD1542 | [5] |
LDCM0304 | AC42 | HEK-293T | C108(0.90) | LDD1543 | [5] |
LDCM0305 | AC43 | HEK-293T | C108(1.00) | LDD1544 | [5] |
LDCM0306 | AC44 | HEK-293T | C108(0.97) | LDD1545 | [5] |
LDCM0307 | AC45 | HEK-293T | C108(0.92) | LDD1546 | [5] |
LDCM0308 | AC46 | HEK-293T | C108(0.83) | LDD1547 | [5] |
LDCM0309 | AC47 | HEK-293T | C108(0.90) | LDD1548 | [5] |
LDCM0310 | AC48 | HEK-293T | C108(1.03) | LDD1549 | [5] |
LDCM0311 | AC49 | HEK-293T | C108(0.93) | LDD1550 | [5] |
LDCM0312 | AC5 | HEK-293T | C108(1.18) | LDD1551 | [5] |
LDCM0313 | AC50 | HEK-293T | C108(0.92) | LDD1552 | [5] |
LDCM0314 | AC51 | HEK-293T | C108(0.92) | LDD1553 | [5] |
LDCM0315 | AC52 | HEK-293T | C108(1.02) | LDD1554 | [5] |
LDCM0316 | AC53 | HEK-293T | C108(0.90) | LDD1555 | [5] |
LDCM0317 | AC54 | HEK-293T | C108(0.87) | LDD1556 | [5] |
LDCM0318 | AC55 | HEK-293T | C108(1.16) | LDD1557 | [5] |
LDCM0319 | AC56 | HEK-293T | C108(0.99) | LDD1558 | [5] |
LDCM0320 | AC57 | HEK-293T | C108(1.01) | LDD1559 | [5] |
LDCM0321 | AC58 | HEK-293T | C108(0.97) | LDD1560 | [5] |
LDCM0322 | AC59 | HEK-293T | C108(0.90) | LDD1561 | [5] |
LDCM0323 | AC6 | PaTu 8988t | C108(0.92) | LDD1202 | [6] |
LDCM0324 | AC60 | HEK-293T | C108(0.93) | LDD1563 | [5] |
LDCM0325 | AC61 | HEK-293T | C108(0.93) | LDD1564 | [5] |
LDCM0326 | AC62 | HEK-293T | C108(0.85) | LDD1565 | [5] |
LDCM0327 | AC63 | HEK-293T | C108(1.04) | LDD1566 | [5] |
LDCM0328 | AC64 | HEK-293T | C108(0.97) | LDD1567 | [5] |
LDCM0334 | AC7 | PaTu 8988t | C108(0.77) | LDD1213 | [6] |
LDCM0345 | AC8 | PaTu 8988t | C108(0.90) | LDD1224 | [6] |
LDCM0248 | AKOS034007472 | PaTu 8988t | C108(0.99) | LDD1127 | [6] |
LDCM0356 | AKOS034007680 | PaTu 8988t | C108(0.45) | LDD1235 | [6] |
LDCM0275 | AKOS034007705 | PaTu 8988t | C108(0.70) | LDD1154 | [6] |
LDCM0367 | CL1 | HEK-293T | C108(0.97) | LDD1571 | [5] |
LDCM0368 | CL10 | HEK-293T | C108(0.76) | LDD1572 | [5] |
LDCM0369 | CL100 | HEK-293T | C108(1.06) | LDD1573 | [5] |
LDCM0370 | CL101 | PaTu 8988t | C108(0.94) | LDD1249 | [6] |
LDCM0371 | CL102 | PaTu 8988t | C108(0.86) | LDD1250 | [6] |
LDCM0372 | CL103 | PaTu 8988t | C108(0.80) | LDD1251 | [6] |
LDCM0373 | CL104 | PaTu 8988t | C108(0.87) | LDD1252 | [6] |
LDCM0374 | CL105 | HEK-293T | C108(0.93) | LDD1578 | [5] |
LDCM0375 | CL106 | HEK-293T | C108(0.92) | LDD1579 | [5] |
LDCM0376 | CL107 | HEK-293T | C108(1.16) | LDD1580 | [5] |
LDCM0377 | CL108 | HEK-293T | C108(0.83) | LDD1581 | [5] |
LDCM0378 | CL109 | HEK-293T | C108(0.92) | LDD1582 | [5] |
LDCM0379 | CL11 | HEK-293T | C108(1.15) | LDD1583 | [5] |
LDCM0380 | CL110 | HEK-293T | C108(0.94) | LDD1584 | [5] |
LDCM0381 | CL111 | HEK-293T | C108(0.86) | LDD1585 | [5] |
LDCM0382 | CL112 | HEK-293T | C108(0.99) | LDD1586 | [5] |
LDCM0383 | CL113 | HEK-293T | C108(0.95) | LDD1587 | [5] |
LDCM0384 | CL114 | HEK-293T | C108(1.05) | LDD1588 | [5] |
LDCM0385 | CL115 | HEK-293T | C108(0.99) | LDD1589 | [5] |
LDCM0386 | CL116 | HEK-293T | C108(1.30) | LDD1590 | [5] |
LDCM0387 | CL117 | HEK-293T | C108(0.92) | LDD1591 | [5] |
LDCM0388 | CL118 | HEK-293T | C108(1.04) | LDD1592 | [5] |
LDCM0389 | CL119 | HEK-293T | C108(0.78) | LDD1593 | [5] |
LDCM0390 | CL12 | HEK-293T | C108(0.70) | LDD1594 | [5] |
LDCM0391 | CL120 | HEK-293T | C108(1.15) | LDD1595 | [5] |
LDCM0392 | CL121 | HEK-293T | C108(1.03) | LDD1596 | [5] |
LDCM0393 | CL122 | HEK-293T | C108(1.28) | LDD1597 | [5] |
LDCM0394 | CL123 | HEK-293T | C108(0.83) | LDD1598 | [5] |
LDCM0395 | CL124 | HEK-293T | C108(1.14) | LDD1599 | [5] |
LDCM0396 | CL125 | HEK-293T | C108(0.87) | LDD1600 | [5] |
LDCM0397 | CL126 | HEK-293T | C108(0.94) | LDD1601 | [5] |
LDCM0398 | CL127 | HEK-293T | C108(0.97) | LDD1602 | [5] |
LDCM0399 | CL128 | HEK-293T | C108(1.38) | LDD1603 | [5] |
LDCM0400 | CL13 | HEK-293T | C108(0.84) | LDD1604 | [5] |
LDCM0401 | CL14 | HEK-293T | C108(1.00) | LDD1605 | [5] |
LDCM0402 | CL15 | HEK-293T | C108(0.74) | LDD1606 | [5] |
LDCM0403 | CL16 | PaTu 8988t | C108(1.16) | LDD1282 | [6] |
LDCM0404 | CL17 | PaTu 8988t | C108(0.95) | LDD1283 | [6] |
LDCM0405 | CL18 | PaTu 8988t | C108(0.81) | LDD1284 | [6] |
LDCM0406 | CL19 | PaTu 8988t | C108(0.86) | LDD1285 | [6] |
LDCM0407 | CL2 | HEK-293T | C108(0.84) | LDD1611 | [5] |
LDCM0408 | CL20 | PaTu 8988t | C108(0.59) | LDD1287 | [6] |
LDCM0409 | CL21 | PaTu 8988t | C108(0.60) | LDD1288 | [6] |
LDCM0410 | CL22 | PaTu 8988t | C108(0.73) | LDD1289 | [6] |
LDCM0411 | CL23 | PaTu 8988t | C108(0.98) | LDD1290 | [6] |
LDCM0412 | CL24 | PaTu 8988t | C108(1.04) | LDD1291 | [6] |
LDCM0413 | CL25 | PaTu 8988t | C108(1.24) | LDD1292 | [6] |
LDCM0414 | CL26 | PaTu 8988t | C108(0.74) | LDD1293 | [6] |
LDCM0415 | CL27 | PaTu 8988t | C108(1.19) | LDD1294 | [6] |
LDCM0416 | CL28 | PaTu 8988t | C108(0.68) | LDD1295 | [6] |
LDCM0417 | CL29 | PaTu 8988t | C108(0.71) | LDD1296 | [6] |
LDCM0418 | CL3 | HEK-293T | C108(0.87) | LDD1622 | [5] |
LDCM0419 | CL30 | PaTu 8988t | C108(1.41) | LDD1298 | [6] |
LDCM0420 | CL31 | PaTu 8988t | C108(1.14) | LDD1299 | [6] |
LDCM0421 | CL32 | PaTu 8988t | C108(1.18) | LDD1300 | [6] |
LDCM0422 | CL33 | PaTu 8988t | C108(0.88) | LDD1301 | [6] |
LDCM0423 | CL34 | PaTu 8988t | C108(1.07) | LDD1302 | [6] |
LDCM0424 | CL35 | PaTu 8988t | C108(0.87) | LDD1303 | [6] |
LDCM0425 | CL36 | PaTu 8988t | C108(1.20) | LDD1304 | [6] |
LDCM0426 | CL37 | PaTu 8988t | C108(0.78) | LDD1305 | [6] |
LDCM0428 | CL39 | PaTu 8988t | C108(1.15) | LDD1307 | [6] |
LDCM0429 | CL4 | HEK-293T | C108(0.83) | LDD1633 | [5] |
LDCM0430 | CL40 | PaTu 8988t | C108(1.08) | LDD1309 | [6] |
LDCM0431 | CL41 | PaTu 8988t | C108(0.75) | LDD1310 | [6] |
LDCM0432 | CL42 | PaTu 8988t | C108(0.46) | LDD1311 | [6] |
LDCM0433 | CL43 | PaTu 8988t | C108(0.32) | LDD1312 | [6] |
LDCM0434 | CL44 | PaTu 8988t | C108(0.78) | LDD1313 | [6] |
LDCM0435 | CL45 | PaTu 8988t | C108(1.06) | LDD1314 | [6] |
LDCM0436 | CL46 | HEK-293T | C108(0.79) | LDD1640 | [5] |
LDCM0437 | CL47 | HEK-293T | C108(0.98) | LDD1641 | [5] |
LDCM0438 | CL48 | HEK-293T | C108(0.75) | LDD1642 | [5] |
LDCM0439 | CL49 | HEK-293T | C108(1.00) | LDD1643 | [5] |
LDCM0440 | CL5 | HEK-293T | C108(0.93) | LDD1644 | [5] |
LDCM0441 | CL50 | HEK-293T | C108(0.96) | LDD1645 | [5] |
LDCM0443 | CL52 | HEK-293T | C108(0.90) | LDD1646 | [5] |
LDCM0444 | CL53 | HEK-293T | C108(0.68) | LDD1647 | [5] |
LDCM0445 | CL54 | HEK-293T | C108(0.28) | LDD1648 | [5] |
LDCM0446 | CL55 | HEK-293T | C108(0.98) | LDD1649 | [5] |
LDCM0447 | CL56 | HEK-293T | C108(1.04) | LDD1650 | [5] |
LDCM0448 | CL57 | HEK-293T | C108(0.77) | LDD1651 | [5] |
LDCM0449 | CL58 | HEK-293T | C108(1.00) | LDD1652 | [5] |
LDCM0450 | CL59 | HEK-293T | C108(1.04) | LDD1653 | [5] |
LDCM0451 | CL6 | HEK-293T | C108(0.83) | LDD1654 | [5] |
LDCM0452 | CL60 | HEK-293T | C108(1.01) | LDD1655 | [5] |
LDCM0453 | CL61 | HEK-293T | C108(1.01) | LDD1656 | [5] |
LDCM0454 | CL62 | HEK-293T | C108(1.00) | LDD1657 | [5] |
LDCM0455 | CL63 | HEK-293T | C108(1.00) | LDD1658 | [5] |
LDCM0456 | CL64 | HEK-293T | C108(1.15) | LDD1659 | [5] |
LDCM0457 | CL65 | HEK-293T | C108(0.82) | LDD1660 | [5] |
LDCM0458 | CL66 | HEK-293T | C108(0.85) | LDD1661 | [5] |
LDCM0459 | CL67 | HEK-293T | C108(0.91) | LDD1662 | [5] |
LDCM0460 | CL68 | HEK-293T | C108(0.88) | LDD1663 | [5] |
LDCM0461 | CL69 | HEK-293T | C108(1.08) | LDD1664 | [5] |
LDCM0462 | CL7 | HEK-293T | C108(0.97) | LDD1665 | [5] |
LDCM0463 | CL70 | HEK-293T | C108(0.90) | LDD1666 | [5] |
LDCM0464 | CL71 | HEK-293T | C108(1.00) | LDD1667 | [5] |
LDCM0465 | CL72 | HEK-293T | C108(0.95) | LDD1668 | [5] |
LDCM0466 | CL73 | HEK-293T | C108(1.00) | LDD1669 | [5] |
LDCM0467 | CL74 | HEK-293T | C108(1.03) | LDD1670 | [5] |
LDCM0469 | CL76 | PaTu 8988t | C108(0.85) | LDD1348 | [6] |
LDCM0470 | CL77 | PaTu 8988t | C108(0.81) | LDD1349 | [6] |
LDCM0471 | CL78 | PaTu 8988t | C108(0.94) | LDD1350 | [6] |
LDCM0472 | CL79 | PaTu 8988t | C108(0.88) | LDD1351 | [6] |
LDCM0473 | CL8 | HEK-293T | C108(0.93) | LDD1676 | [5] |
LDCM0474 | CL80 | PaTu 8988t | C108(1.19) | LDD1353 | [6] |
LDCM0475 | CL81 | PaTu 8988t | C108(0.98) | LDD1354 | [6] |
LDCM0476 | CL82 | PaTu 8988t | C108(1.02) | LDD1355 | [6] |
LDCM0477 | CL83 | PaTu 8988t | C108(0.83) | LDD1356 | [6] |
LDCM0478 | CL84 | PaTu 8988t | C108(0.68) | LDD1357 | [6] |
LDCM0479 | CL85 | PaTu 8988t | C108(0.94) | LDD1358 | [6] |
LDCM0480 | CL86 | PaTu 8988t | C108(1.23) | LDD1359 | [6] |
LDCM0481 | CL87 | PaTu 8988t | C108(0.66) | LDD1360 | [6] |
LDCM0482 | CL88 | PaTu 8988t | C108(0.89) | LDD1361 | [6] |
LDCM0483 | CL89 | PaTu 8988t | C108(0.67) | LDD1362 | [6] |
LDCM0484 | CL9 | HEK-293T | C108(0.90) | LDD1687 | [5] |
LDCM0485 | CL90 | PaTu 8988t | C108(0.89) | LDD1364 | [6] |
LDCM0486 | CL91 | HEK-293T | C108(0.93) | LDD1689 | [5] |
LDCM0487 | CL92 | HEK-293T | C108(1.02) | LDD1690 | [5] |
LDCM0488 | CL93 | HEK-293T | C108(0.91) | LDD1691 | [5] |
LDCM0489 | CL94 | HEK-293T | C108(0.81) | LDD1692 | [5] |
LDCM0490 | CL95 | HEK-293T | C108(0.73) | LDD1693 | [5] |
LDCM0491 | CL96 | HEK-293T | C108(0.76) | LDD1694 | [5] |
LDCM0492 | CL97 | HEK-293T | C108(0.86) | LDD1695 | [5] |
LDCM0493 | CL98 | HEK-293T | C108(0.93) | LDD1696 | [5] |
LDCM0494 | CL99 | HEK-293T | C108(0.97) | LDD1697 | [5] |
LDCM0495 | E2913 | HEK-293T | C108(1.07) | LDD1698 | [5] |
LDCM0468 | Fragment33 | HEK-293T | C108(0.92) | LDD1671 | [5] |
LDCM0427 | Fragment51 | PaTu 8988t | C108(1.05) | LDD1306 | [6] |
LDCM0022 | KB02 | HEK-293T | C108(0.98) | LDD1492 | [5] |
LDCM0023 | KB03 | HEK-293T | C108(1.06) | LDD1497 | [5] |
LDCM0024 | KB05 | NCI-H196 | C108(0.92) | LDD3351 | [2] |
References