Details of the Target

General Information of Target

Target ID LDTP01348
Target Name Cyclin-K (CCNK)
Gene Name CCNK
Gene ID 8812
Synonyms
CPR4; Cyclin-K
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDV
GTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTA
RSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQK
LVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQ
DVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPS
QPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIET
THPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRP
PPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPP
NPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGL
PPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR
Target Bioclass
Other
Family
Cyclin family, Cyclin C subfamily
Subcellular location
Nucleus
Function
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Uniprot ID
O75909
Ensemble ID
ENST00000389879.9
HGNC ID
HGNC:1596
ChEMBL ID
CHEMBL2346490

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.90  LDD0402  [1]
BTD
 Probe Info  		C113(0.46)  LDD2122  [2]
DBIA
 Probe Info  		C23(1.04); C98(0.98); C99(0.98)  LDD1492  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		C23(0.00); C99(0.00); C98(0.00)  LDD2156  [6]
AOyne
 Probe Info  		9.10  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C23(0.96)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C23(0.90)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C23(0.87)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C23(0.98)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C23(0.93)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C23(0.98)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C23(1.05)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C23(0.97)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C23(0.93)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C23(0.90)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C23(1.02)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C23(1.04)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C23(0.93)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C23(1.02)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C23(1.00)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C23(1.03)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C23(0.85)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C23(0.90)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C23(1.03)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C23(0.98)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C23(0.95)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C23(0.89)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C23(1.02)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C23(0.88)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C23(0.91)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C23(0.89)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C23(0.87)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C23(0.98)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C23(0.98)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C23(0.89)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C23(0.95)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C23(1.04)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C23(0.91)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C23(0.94)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C23(0.89)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C23(0.84)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C23(0.91)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C23(0.99)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C23(0.88)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C23(0.94)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C23(0.87)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C23(0.99)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C23(0.97)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C23(0.94)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C23(0.92)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C23(1.02)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C23(1.03)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C23(0.97)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C23(1.00)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C23(0.93)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C23(1.00)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C23(0.85)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C23(0.85)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C23(0.95)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C23(0.97)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C23(1.00)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C23(0.90)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C23(0.92)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C23(0.90)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C23(0.97)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C23(0.91)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C23(0.96)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C23(0.97)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C23(0.89)  LDD1514  [3]
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C23(0.89)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C23(1.21)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C23(0.96)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C23(0.97)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C23(0.97)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C23(0.88)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C23(0.94)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C23(1.01)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C23(0.96)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C23(0.94)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C23(0.96)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C23(1.04)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C23(0.71)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C23(0.96)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C23(1.06)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C23(0.96)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C23(0.91)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C23(0.91)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C23(0.96)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C23(0.93)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C23(0.94)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C23(0.87)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C23(0.88)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C23(0.73)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C23(0.90)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C23(0.97)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C23(0.99)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C23(0.94)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C23(1.03)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C23(0.91)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C23(0.93)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C23(0.95)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C23(0.91)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C23(1.05)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C23(1.09)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C23(1.11)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C23(1.09)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C23(1.17)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C23(1.05)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C23(1.10)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C23(0.98)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C23(0.98)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C23(0.84)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C23(1.28)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C23(0.74)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C23(0.76)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C23(0.91)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C23(0.96)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C23(0.97)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C23(0.96)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C23(0.97)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C23(1.00)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C23(0.98)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C23(1.05)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C23(0.84)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C23(0.73)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C23(1.22)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C23(0.65)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C23(0.74)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C23(0.95)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C23(0.95)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C23(0.98)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C23(1.05)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C23(1.09)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C23(1.02)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C23(0.96)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C23(0.89)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C23(0.74)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C23(1.32)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C23(0.69)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C23(0.71)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C23(0.92)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C23(1.11)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C23(0.94)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C23(0.89)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C23(1.00)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C23(0.86)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C23(0.95)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C23(0.82)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C23(0.71)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C23(1.12)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C23(0.68)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C23(0.93)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C23(0.69)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C23(0.92)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C23(0.86)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C23(0.85)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C23(0.92)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C23(0.97)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C23(0.89)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C23(0.92)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C23(0.80)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C23(0.68)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C23(1.00)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C23(1.09)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C23(0.72)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C23(0.67)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C23(0.93)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C23(0.96)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C23(1.00)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C23(1.07)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C23(0.90)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C23(0.92)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C23(0.95)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C23(0.86)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C23(0.78)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C23(1.01)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C23(0.74)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C23(0.78)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C23(0.96)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C23(0.99)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C23(0.91)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C23(1.00)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C23(1.05)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C23(0.72)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C23(0.97)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C23(0.93)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C23(0.87)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C23(0.84)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C23(1.03)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C23(0.83)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C23(0.84)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C23(0.99)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C23(0.92)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C23(0.90)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C23(0.85)  LDD1698  [3]
 LDCM0625  F8 Ramos C23(7.69)  LDD2187  [9]
 LDCM0573  Fragment11 Ramos C23(3.88)  LDD2190  [9]
 LDCM0576  Fragment14 Ramos C23(1.35)  LDD2193  [9]
 LDCM0586  Fragment28 Ramos C23(0.46)  LDD2198  [9]
 LDCM0468  Fragment33 HEK-293T C23(0.94)  LDD1671  [3]
 LDCM0566  Fragment4 Ramos C23(3.94)  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C23(1.00)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C23(1.04); C98(0.98); C99(0.98)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C23(1.11); C98(0.93); C99(0.93)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C23(1.04); C98(1.06); C99(1.06)  LDD1502  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C113(0.46)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C113(0.16)  LDD2124  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Cyclin-dependent kinase 13 (CDK13) CMGC Ser/Thr protein kinase family Q14004
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Heat shock transcription factor, Y-linked (HSFY1; HSFY2) HSF family Q96LI6
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Proline-rich protein 20D (PRR20D) PRR20 family P86480
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) . P55795
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578