Details of the Target

General Information of Target

Target ID LDTP01131
Target Name Protein cordon-bleu (COBL)
Gene Name COBL
Gene ID 23242
Synonyms
KIAA0633; Protein cordon-bleu
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGALGSQQNLVRMKEALRA
STMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSHHALEIRSSETQQPLSFKP
NTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVNYLRTQKAVVRVSPEVPLQNI
LPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRRETFRKSSLGNDE
TDKEKKKFLGFFKVNKRSNSKGCLTTPNSPSMHSRSLTLGPSLSLGSISGVSVKSEMKKR
RAPPPPGSGPPVQDKASEKVSLGSQIDLQKKKRRAPAPPPPQPPPPSPLIPNRTEDKEEN
RKSTMVSLPLGSGSHCSPDGAPQVLSEAEETVSVGSCFASEDTTEDSGVMSSPSDIVSLD
SQQDSMKYKDKWATDQEDCSDQDLAGTPDLGPQKSPLWEKNGSENSHLRTEKAVTASNDE
EDLLIAGEFRKTLAELDEDLEEMEDSYETDTSSLTSSIHGASNHCPQDAMIPHGDTDAIP
VTFIGEVSDDPVDSGLFSNRNNNAGSFDSEGVASRRDSLAPLQAEHSQPHEKAREEVPAL
HPASHDVGKGIRVALSNISKDGNLMETAPRVTSFASNLHTDNLNAKVKDKVYGCADGERT
QATERVNSQPVNEKDSNDKNAALAPTSWHQRGQNPGKSYRLKHGLTTYKIIPPKSEMRCY
DRDVSLSTGAIKIDELGNLVSPHATGIRIISLSSSVPEAESQPIGKVREFWRCNSVEKHL
GRPSESSARGPPSTPVPTQTQNPESRLQADPKPISPQQKSAHHEGRNPLGEGRNQPPTMG
MGHVRVPAAHTTEVTFLKPQRRTSSQYVASAIAKRIGAPKVHADVVRPHGYAEKGYAGKA
PVLAAPPVTVKDDRTSSPHSETQGWKDGAQWPCVTPPNNHGEDLAVGAPPRGEVIGPHRK
LSTQDRPAAIHRSSCFSLVQSSQRDRVSVGQSCGFSGKQSTSSQEASSASEPRRAPDGTD
PPPPHTSDTQACSRELVNGSVRAPGHGEPSHPPGGSGTESHILLEREEKPSVFSTDGNET
DSIWPPSIFGPKKKFKPVVQRPVPKDTSLHSALMEAIHSAGGKDRLRKTAEHTGEGRPAK
LSYTEAEGERSALLAAIRGHSGTCSLRKVASSASEELQSFRDAALSAQGSESPLLEDLGL
LSPPAIPPPPPPPSQALSAPRTASRFSTGTLSNTADARQALMDAIRSGTGAARLRKVPLL
V
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.
Uniprot ID
O75128
Ensemble ID
ENST00000265136.12
HGNC ID
HGNC:22199

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.R1255T .
CAL27 SNV: p.Q114K .
CAMA1 SNV: p.K431N .
CMK SNV: p.F252Y .
COLO678 SNV: p.A57V DBIA    Probe Info 
HT SNV: p.Q1030R .
IM95 SNV: p.E824K DBIA    Probe Info 
JHH7 SNV: p.I618S .
KPNYN SNV: p.G307C .
KYSE150 SNV: p.Q980Ter DBIA    Probe Info 
MEWO SNV: p.S668F; p.E760K .
NALM6 SNV: p.R1013K .
NB1 SNV: p.H130R .
NCIH1155 SNV: p.T241I DBIA    Probe Info 
NCIH1703 SNV: p.G898A .
NUGC3 SNV: p.E1065Ter .
SG231 SNV: p.R1034S DBIA    Probe Info 
SISO SNV: p.S463Y DBIA    Probe Info 
SKMEL5 SNV: p.N694K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y652(38.08)  LDD3495  [1]
DBIA
 Probe Info  		C736(2.05)  LDD3321  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [5]
IPM
 Probe Info  		C1032(0.00); C975(0.00); C993(0.00)  LDD0025  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1164(1.08); C654(0.87); C993(0.97)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C1164(1.01); C654(0.95); C185(1.09); C993(0.99)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C654(0.95); C1032(1.11)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C1164(1.01); C654(1.08); C185(0.90); C993(1.05)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C1164(1.00); C654(1.02); C185(1.60); C993(0.99)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C1164(1.10); C654(1.02); C185(0.92); C993(0.92)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C1164(1.22); C654(0.94); C993(1.10)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C1164(0.98); C654(1.08); C185(0.98); C993(0.98)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C654(1.15); C1032(1.03)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C1164(1.04); C654(1.00); C185(1.06); C993(0.97)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C1164(1.09); C654(1.11); C185(1.22); C993(1.07)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C1164(0.84); C654(1.05); C993(1.15); C975(1.04)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C1164(1.07); C654(1.04); C185(1.35); C993(0.83)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C1164(1.09); C654(0.95); C185(1.07); C993(0.99)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C1164(0.99); C654(1.14); C933(0.84); C975(0.95)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C1164(1.08); C654(1.01); C993(1.06)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C1164(1.07); C654(1.09); C185(0.82); C993(0.99)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C654(0.98); C1032(0.99)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C1164(0.87); C654(0.97); C185(1.16); C993(1.04)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C1164(1.07); C654(1.09); C993(1.14); C975(0.97)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C654(0.97); C1032(0.98)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C1164(0.92); C654(1.03); C185(1.13); C993(0.97)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C1164(0.99); C654(1.05); C185(1.08); C993(1.04)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C1164(0.90); C654(1.11); C933(0.89); C975(0.88)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C1164(1.10); C654(0.91); C993(0.96)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C1164(1.00); C654(1.10); C185(0.94); C993(1.01)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C654(0.96); C1032(0.93)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C1164(1.22); C654(1.07); C185(0.81); C993(0.96)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C1164(0.97); C654(1.05); C993(0.71); C975(0.74)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C1164(1.03); C654(1.03); C185(1.35); C993(1.02)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C1164(1.13); C654(1.05); C185(1.15); C993(0.92)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C1164(1.17); C654(0.98); C185(0.86); C993(1.06)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C1164(1.03); C654(1.06); C933(0.97); C975(0.85)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C1164(1.06); C654(0.89); C993(1.01)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C1164(1.12); C654(1.06); C185(1.15); C993(1.06)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C654(0.97); C1032(1.17)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C1164(1.04); C654(1.01); C185(1.29); C993(1.02)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C1164(1.14); C654(1.12); C993(0.78); C975(0.93)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C1164(1.08); C654(1.10); C185(1.46); C993(1.10)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C1164(0.99); C654(1.04); C185(1.18); C993(0.95)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C1164(0.99); C654(1.07); C933(1.04); C975(0.94)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C1164(1.01); C654(1.07); C993(1.07)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C1164(1.04); C654(1.08); C993(1.12); C975(1.00)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C1164(1.01); C654(0.99); C185(0.98); C993(1.02)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C654(1.00); C1032(0.99)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C1164(1.11); C654(1.04); C185(0.81); C993(1.05)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C1164(0.97); C654(0.97); C993(1.02); C975(0.89)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C1164(0.88); C654(1.05); C185(1.27); C993(1.02)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C1164(1.01); C654(0.97); C185(1.44); C993(0.89)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C1164(0.91); C654(1.05); C933(1.07); C975(0.89)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C1164(0.99); C654(0.94); C993(1.15)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C1164(0.94); C654(0.96); C185(1.22); C993(1.00)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C654(0.96); C1032(0.80)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C1164(1.04); C654(1.06); C185(1.51); C993(1.06)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C1164(1.07); C654(1.06); C185(1.14); C993(0.99)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C1164(0.96); C654(1.02); C993(1.16); C975(1.01)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C1164(0.89); C654(1.01); C185(1.33); C993(0.99)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C1164(1.10); C654(0.99); C185(1.23); C993(1.01)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C1164(0.87); C654(1.11); C933(1.02); C975(0.94)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C1164(1.01); C654(1.06); C185(1.30); C993(0.93)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C1164(1.00); C654(0.91); C933(0.97); C975(0.93)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C1164(1.03); C654(0.94); C993(0.82); C975(0.76)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C1164(1.09); C654(0.92); C993(1.19)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C1164(0.99); C654(1.03); C933(0.95); C975(0.91)  LDD1514  [10]
 LDCM0632  CL-Sc Hep-G2 C1032(1.18)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C1164(0.91); C654(0.78); C185(1.41)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C1164(1.43); C654(0.94); C185(1.33); C993(0.91)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C654(0.98); C185(0.91); C993(1.06); C975(1.07)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C1164(1.03); C654(0.94); C185(0.98)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C654(1.08); C185(0.99); C993(0.86); C933(1.01)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C1164(1.03); C654(1.11); C993(1.02)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C654(0.99); C185(1.17); C993(0.96); C975(0.90)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C1164(1.10); C654(0.91); C185(0.99)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C654(1.07); C185(0.92); C993(0.88); C933(0.99)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C1164(0.97); C654(1.00); C993(1.00)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C654(1.08); C185(1.10); C993(1.13); C975(0.91)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C1164(1.05); C654(0.90); C185(1.07)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C1164(1.39); C654(1.11); C185(1.00); C993(0.91)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C654(1.03); C185(1.09); C993(0.89); C933(1.02)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C1164(1.05); C654(0.90); C993(1.03)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C654(0.99); C185(0.89); C993(1.19); C975(1.07)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C1164(1.21); C654(0.97); C185(1.04)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C654(0.92); C185(1.08); C993(0.89); C933(1.54)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C1164(1.07); C654(1.15); C993(0.97)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C654(0.99); C185(0.93); C993(0.96); C975(1.04)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C1164(1.14); C654(0.97); C185(1.41)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C654(1.13); C185(1.09); C993(0.96); C933(1.11)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C1164(1.10); C654(0.99); C993(1.09)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C1164(1.21); C654(1.08); C933(0.90); C975(1.27)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C654(1.10); C185(1.28); C993(1.07); C975(0.97)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C1164(0.92); C654(0.98); C185(1.29)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C654(1.00); C185(0.88); C993(0.85); C933(0.99)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C1164(0.98); C654(1.01); C993(0.92)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C654(0.92); C185(1.18); C993(1.03); C975(0.95)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C1164(0.84); C654(0.98); C185(1.10)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C654(1.07); C185(1.03); C993(0.93); C933(1.23)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C1164(0.84); C654(1.08); C993(1.04)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C654(1.00); C185(1.22); C993(1.07); C975(1.04)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C1164(0.98); C654(1.01); C185(0.91)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C654(1.09); C185(1.03); C993(0.93); C933(1.30)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C1164(0.89); C654(1.00); C993(1.06)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C654(1.01); C185(1.25); C993(0.96); C975(0.81)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C1164(1.02); C654(0.86); C993(0.97)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C1164(1.01); C654(1.04); C185(0.50); C993(1.01)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C654(0.98); C1032(0.96)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C654(1.13); C185(1.11); C993(0.91); C933(1.30)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C1164(1.31); C654(1.10); C185(1.11); C993(0.98)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C1164(1.14); C654(1.16); C993(1.15); C975(1.24)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C1164(1.09); C654(1.05); C185(1.23); C993(1.09)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C1164(1.32); C654(0.92); C185(1.33); C993(0.90)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C1164(1.11); C654(1.08); C933(0.82); C975(1.31)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C1164(0.93); C654(0.90); C185(1.68)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C654(0.94); C185(0.99); C993(0.93); C933(1.23)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C1164(1.04); C654(1.05); C993(1.00)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C654(0.98); C185(1.16); C993(1.09); C975(0.81)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C1164(0.97); C654(0.95); C993(1.09)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C1164(1.04); C654(1.06); C993(1.06)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C1164(1.03); C654(1.05); C185(1.12); C993(0.98)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C654(1.04); C1032(0.84)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C1164(1.30); C654(1.11); C185(1.04); C993(1.04)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C1164(1.08); C654(1.01); C993(1.03); C975(1.39)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C1164(1.19); C654(0.98); C185(1.27); C993(1.09)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C1164(1.24); C654(1.10); C185(1.65); C993(1.01)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C1164(1.17); C654(1.00); C933(1.03); C975(1.19)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C1164(0.80); C654(0.92); C185(1.04)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C1164(1.02); C654(1.08); C993(1.07)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C654(0.96); C185(0.90); C993(1.04); C975(0.98)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C654(0.99); C185(1.03); C993(0.94); C975(1.32)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C1164(1.08); C654(1.10); C993(0.97)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C1164(0.97); C654(0.99); C185(1.34); C993(1.11)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C654(0.98); C1032(0.91)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C1164(1.25); C654(1.12); C185(1.14); C993(1.00)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C1164(1.35); C654(1.00); C993(1.03); C975(1.21)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C1164(1.29); C654(1.04); C185(1.47); C993(1.08)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C1164(1.50); C654(1.08); C185(1.22); C993(0.96)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C1164(1.04); C654(1.08); C933(1.01); C975(0.97)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C1164(0.89); C654(1.01); C185(1.15)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C1164(1.01); C654(0.94); C993(1.12)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C654(1.08); C185(1.13); C993(0.87); C933(1.00)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C654(1.10); C185(1.22); C993(1.04); C975(1.19)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C1164(1.14); C654(1.06); C993(0.93)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C1164(0.97); C654(0.87); C185(0.71); C993(1.05)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C654(1.06); C1032(1.01)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C1164(1.17); C654(1.09); C185(1.00); C993(1.08)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C1164(1.22); C654(1.21); C993(1.36); C975(1.31)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C1164(1.10); C654(1.14); C185(1.36); C993(1.18)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C1164(1.38); C654(1.06); C185(1.23); C993(0.94)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C1164(0.87); C654(0.94); C185(0.80); C993(1.09)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C1164(1.40); C654(1.07); C933(1.10); C975(1.15)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C1164(1.04); C654(0.91); C185(1.26)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C654(1.05); C185(1.11); C993(0.96); C933(1.27)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C1164(1.02); C654(1.11); C993(1.02)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C654(1.14); C185(1.10); C993(0.96); C975(0.85)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C1164(1.12); C654(0.96); C993(1.12)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C1164(1.05); C654(0.96); C185(0.92); C993(0.99)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C654(0.98); C1032(1.06)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C1164(1.23); C654(1.02); C185(1.31); C993(1.08)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C1164(1.06); C654(1.00); C993(0.79); C975(1.27)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C654(0.89); C1032(0.85)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C1164(1.21); C654(1.09); C185(1.26); C993(1.06)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C1164(1.28); C654(1.06); C185(1.34); C993(1.01)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C1164(1.14); C654(1.13); C933(0.91); C975(1.18)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C1164(0.98); C654(0.94); C185(1.03)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C654(1.05); C185(1.15); C993(0.91); C933(1.08)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C654(0.99); C185(1.16); C993(1.05); C975(0.91)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C1164(0.95); C654(0.93); C993(1.13)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C1164(0.98); C654(1.06); C185(1.07); C993(1.00)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C654(0.86); C1032(0.92)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C1164(1.04); C654(0.75); C185(1.01); C993(0.96)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C1164(1.03); C654(0.97); C185(1.26); C993(1.00)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C1164(1.09); C654(1.13); C993(1.09); C975(0.98)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C1164(1.11); C654(1.02); C185(1.13); C993(0.99)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C1164(1.14); C654(0.97); C185(1.55); C993(0.94)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C1164(0.97); C654(1.07); C933(0.90); C975(1.17)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C1164(0.75); C654(0.90); C185(0.99)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C654(1.02); C185(1.10); C993(0.92); C933(0.96)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C1164(0.77); C654(1.06); C993(1.03)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C654(1.06); C185(1.14); C993(1.14); C975(1.36)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C1164(0.84); C654(0.86); C993(1.05)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C1164(1.10); C654(1.14); C993(0.98); C975(1.10)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C1164(0.78); C654(0.92); C185(0.77); C993(0.97)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C654(0.98); C1032(0.79)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C1164(0.89); C654(0.96); C185(1.07); C993(0.99)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C1164(0.93); C654(1.05); C993(1.28); C975(1.21)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C1164(1.16); C654(1.08); C185(1.68); C993(1.23)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C1164(1.09); C654(0.95); C185(0.93); C993(1.06)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C1164(0.84); C654(1.07); C933(0.82); C975(0.97)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C1164(0.98); C654(1.00); C185(0.78)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C654(1.00); C185(0.95); C993(0.91); C933(0.95)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C1164(0.96); C654(1.06); C993(1.12)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C1164(1.08); C654(1.04); C993(1.06)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C1164(0.89); C654(1.07); C993(1.06)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C654(1.03); C185(1.20); C993(0.89); C933(1.46)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C654(0.99)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C654(1.06)  LDD1497  [10]
 LDCM0024  KB05 SH4 C736(2.05)  LDD3321  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) PACSIN family Q9BY11
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) PACSIN family Q9UNF0

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402