Details of the Target

General Information of Target

Target ID LDTP00951
Target Name Zinc finger E-box-binding homeobox 2 (ZEB2)
Gene Name ZEB2
Gene ID 9839
Synonyms
KIAA0569; SIP1; ZFHX1B; ZFX1B; Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQET
SPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTM
GPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAP
EELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEEN
FSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEH
LRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSS
PTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGL
GATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKA
EEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACL
QSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHE
RYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLK
AYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSN
PPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRS
NTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKAS
SISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPP
QSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQG
FQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYE
HTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSY
CKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEH
EKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKME
TKSDHEEDNMEDGM
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Delta-EF1/ZFH-1 C2H2-type zinc-finger family
Subcellular location
Nucleus
Function Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2.
TTD ID
T38453
Uniprot ID
O60315
DrugMap ID
TTT2WK4
Ensemble ID
ENST00000409487.7
HGNC ID
HGNC:14881

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R156H; p.R988C .
A2058 SNV: p.K1053E DBIA    Probe Info 
AN3CA SNV: p.R548M .
CAL72 SNV: p.D927Y .
COLO678 Deletion: p.R14NfsTer11 .
COLO792 Deletion: p.D116TfsTer20 DBIA    Probe Info 
KMCH1 SNV: p.R560S .
KMS11 SNV: p.K643N .
KNS81FD SNV: p.D630V .
KYSE180 SNV: p.E1165K .
KYSE410 SNV: p.D948Y; p.E1168K .
L428 Insertion: p.M476NfsTer6 .
MDAMB453 SNV: p.D1123H .
MELHO Deletion: p.R14NfsTer11 .
NALM6 SNV: p.Q1072K .
NCIH2286 Substitution: p.P122R .
NCIH23 SNV: p.E1128D .
NCIH358 SNV: p.P446T .
NCIN87 SNV: p.L448R .
OV90 SNV: p.N1209S .
OVISE SNV: p.R218L .
PC9 SNV: p.D118G .
RKO SNV: p.Q127Ter .
RPMI8226 Substitution: p.M736V .
SKMEL28 Substitution: p.S982F DBIA    Probe Info 
SUPT1 SNV: p.R258Q .
SW480 SNV: p.H599Q .
SW620 Deletion: p.R14NfsTer11 .
TFK1 SNV: p.Q962Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C539(2.05)  LDD0170  [1]
DBIA
 Probe Info  		C583(1.52); C586(1.52)  LDD0080  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C539(2.05)  LDD0170  [1]
 LDCM0214  AC1 HEK-293T C140(1.16)  LDD1507  [4]
 LDCM0226  AC11 HEK-293T C140(0.82)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C140(0.99); C539(1.13)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C140(1.02); C539(1.07)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C140(1.13); C539(0.98)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C140(1.21)  LDD1515  [4]
 LDCM0278  AC19 HEK-293T C140(1.08)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C140(1.09); C539(1.01)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C140(1.05); C539(0.95)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C140(0.91); C539(1.01)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C140(0.97); C539(1.06)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C539(0.99)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C140(1.21)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C140(0.90)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C140(0.98); C539(1.08)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C140(1.07); C539(0.99)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C140(0.96)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C140(1.08); C539(1.00)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C140(0.96); C539(0.88)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C539(0.86)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C140(1.20)  LDD1533  [4]
 LDCM0296  AC35 HEK-293T C140(1.21)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C140(1.04); C539(1.12)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C140(0.98); C539(0.91)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C140(1.00); C539(0.96)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C140(1.14); C539(0.98)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C140(1.07); C539(0.85)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C539(1.06)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C140(1.19)  LDD1542  [4]
 LDCM0305  AC43 HEK-293T C140(0.99)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C140(0.98); C539(1.05)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C140(1.12); C539(1.04)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C140(1.04); C539(1.04)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C140(1.23); C539(1.02)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C539(1.17)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C140(1.23)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C140(0.96); C539(0.99)  LDD1551  [4]
 LDCM0314  AC51 HEK-293T C140(1.07)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C140(1.04); C539(0.97)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C140(1.09); C539(1.00)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C140(1.11); C539(1.07)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C140(1.12); C539(0.92)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C539(0.96)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C140(1.07)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C140(1.03)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C140(0.97); C539(1.09)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C140(0.98); C539(1.05)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C140(0.93); C539(1.04)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C140(1.00); C539(1.02)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C140(1.05); C539(0.88)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C539(0.96)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C140(1.07); C539(0.81)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C539(0.94)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C140(1.04); C539(1.03)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C140(1.17)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C539(1.08)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C140(0.86)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C140(0.91); C539(1.35)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C140(1.09)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C140(1.12)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C539(0.94)  LDD1576  [4]
 LDCM0374  CL105 HEK-293T C140(0.95)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C140(1.16)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C539(0.96)  LDD1580  [4]
 LDCM0378  CL109 HEK-293T C140(0.86)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C140(1.08); C539(1.04)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C140(1.15)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C539(0.83)  LDD1585  [4]
 LDCM0383  CL113 HEK-293T C140(1.00)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C140(1.20)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C539(1.08)  LDD1589  [4]
 LDCM0387  CL117 HEK-293T C140(1.05)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C140(1.30)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C539(1.09)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C539(1.21)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C140(0.91)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C140(1.26)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C539(0.90)  LDD1598  [4]
 LDCM0396  CL125 HEK-293T C140(1.03)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C140(1.14)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C539(0.98)  LDD1602  [4]
 LDCM0400  CL13 HEK-293T C140(1.07)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C140(1.25)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C539(0.97)  LDD1606  [4]
 LDCM0404  CL17 HEK-293T C140(1.15)  LDD1608  [4]
 LDCM0406  CL19 HEK-293T C140(0.94)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C140(1.17)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C140(1.12); C539(1.26)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C140(0.98); C539(0.99)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C140(1.08); C539(1.11)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C140(1.28); C539(1.14)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C539(1.18)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C140(1.02)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C140(1.09)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C539(1.00)  LDD1619  [4]
 LDCM0417  CL29 HEK-293T C140(1.16)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C539(1.13)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C140(0.91)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C140(1.08); C539(1.09)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C140(1.02); C539(0.95)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C140(1.11); C539(1.09)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C140(0.90); C539(1.10)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C539(1.29)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C140(0.91)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C539(0.89)  LDD1632  [4]
 LDCM0431  CL41 HEK-293T C140(1.06)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C140(0.83)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C140(1.12); C539(1.05)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C140(1.04); C539(1.07)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C140(0.99); C539(1.10)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C140(1.08); C539(0.96)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C539(1.30)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C140(0.94)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C140(1.19)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C140(1.25)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C140(1.13)  LDD1647  [4]
 LDCM0446  CL55 HEK-293T C140(0.98)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C140(1.08); C539(1.06)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C140(0.95); C539(1.26)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C140(1.16); C539(1.19)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C140(1.17); C539(1.13)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C539(1.15)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C140(1.01)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C140(1.05)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C539(0.88)  LDD1658  [4]
 LDCM0457  CL65 HEK-293T C140(1.20)  LDD1660  [4]
 LDCM0459  CL67 HEK-293T C140(0.89)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C140(1.08); C539(1.01)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C140(1.04); C539(1.02)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C140(0.93)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C140(1.13); C539(1.14)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C140(1.15); C539(1.02)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C539(1.10)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C140(0.94)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C140(1.28)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C140(0.97)  LDD1673  [4]
 LDCM0472  CL79 HEK-293T C140(1.02)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C140(0.84); C539(1.09)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C140(1.15); C539(1.14)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C140(1.23); C539(0.93)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C140(0.99); C539(1.14)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C140(1.00); C539(1.09)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C539(1.35)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C140(0.81)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C140(1.11)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C539(1.03)  LDD1684  [4]
 LDCM0483  CL89 HEK-293T C140(1.04)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C140(1.03); C539(0.98)  LDD1687  [4]
 LDCM0486  CL91 HEK-293T C140(0.85)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C140(0.97); C539(1.19)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C140(0.96); C539(0.98)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C140(1.06); C539(1.11)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C140(1.09); C539(1.16)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C539(1.56)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C140(0.84)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C140(1.19)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C539(0.91)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C539(1.09)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C539(1.08)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C140(1.17)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C583(1.52); C586(1.52)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C583(2.14); C586(2.14)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C583(1.78); C586(1.78)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metastasis-associated protein MTA1 (MTA1) . Q13330
Metastasis-associated protein MTA2 (MTA2) . O94776

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402