Details of the Target

General Information of Target

Target ID LDTP00613
Target Name Tumor protein p73 (TP73)
Gene Name TP73
Gene ID 7161
Synonyms
P73; Tumor protein p73; p53-like transcription factor; p53-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTS
VMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTD
YPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPV
YKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPY
EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGR
DRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVR
GRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGG
MNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSH
CTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
IWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRG
GPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH
Target Bioclass
Transcription factor
Family
P53 family
Subcellular location
Nucleus
Function
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression. It is an essential factor for the positive regulation of lung ciliated cell differentiation.
Uniprot ID
O15350
Ensemble ID
ENST00000346387.8
HGNC ID
HGNC:12003

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.S134P .
HGC27 SNV: p.P335L .
LNCaP clone FGC SNV: p.Y487H .
MINO SNV: p.R216H .
NB1 SNV: p.G408W .
NCIH1155 SNV: p.G264W .
NCIH661 SNV: p.G37A .
SNU5 SNV: p.G451W .
THP1 SNV: p.D305N .
TOV21G SNV: p.G457C; p.E465Ter .
WM2664 Insertion: p.H96PfsTer33 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C82(2.53)  LDD3313  [1]
IA-alkyne
 Probe Info  		C258(0.26); C262(0.26)  LDD2214  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C194(1.09)  LDD1508  [4]
 LDCM0237  AC12 HEK-293T C194(1.12)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C194(1.00)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C194(0.98)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C194(1.08)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C194(1.08)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C194(1.05)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C194(1.00)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C194(0.93)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C194(0.85)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C194(1.06)  LDD1525  [4]
 LDCM0288  AC28 HEK-293T C194(1.13)  LDD1527  [4]
 LDCM0291  AC30 HEK-293T C194(1.05)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C194(1.03)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C194(1.06)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C194(1.10)  LDD1534  [4]
 LDCM0297  AC36 HEK-293T C194(1.16)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C194(1.19)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C194(0.98)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C194(1.01)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C194(1.06)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C194(1.00)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C194(1.23)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C194(1.09)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C194(0.87)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C194(0.95)  LDD1549  [4]
 LDCM0313  AC50 HEK-293T C194(0.99)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C194(1.09)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C194(1.12)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C194(0.99)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C194(0.98)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C194(1.07)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C194(0.98)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C194(1.10)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C194(0.96)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C194(1.05)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C194(0.89)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C194(0.98)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C194(0.85)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C194(0.87)  LDD1514  [4]
 LDCM0630  CCW28-3 231MFP C258(0.26); C262(0.26)  LDD2214  [2]
 LDCM0368  CL10 HEK-293T C194(1.05)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C194(0.94)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C194(1.01)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C194(1.19)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C194(1.05)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C194(0.98)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C194(1.17)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C194(1.03)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C194(1.17)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C194(0.94)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C194(1.13)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C194(0.99)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C194(1.10)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C194(1.25)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C194(0.97)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C194(1.16)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C194(1.07)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C194(1.18)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C194(1.16)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C194(1.00)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C194(1.14)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C194(0.84)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C194(0.90)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C194(1.03)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C194(0.96)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C194(1.01)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C194(1.28)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C194(1.01)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C194(1.17)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C194(1.06)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C194(1.10)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C194(1.26)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C194(1.20)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C194(1.09)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C194(1.06)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C194(1.15)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C194(1.02)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C194(1.19)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C194(1.17)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C194(1.13)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C194(0.98)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C194(1.01)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C194(1.02)  LDD1629  [4]
 LDCM0428  CL39 HEK-293T C194(1.26)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C194(1.05)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C194(1.09)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C194(1.13)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C194(1.04)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C194(1.06)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C194(1.02)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C194(0.92)  LDD1642  [4]
 LDCM0441  CL50 HEK-293T C194(1.00)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C194(1.02)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C194(1.01)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C194(1.17)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C194(1.19)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C194(1.09)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C194(1.22)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C194(0.97)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C194(1.05)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C194(1.11)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C194(1.10)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C194(1.10)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C194(1.19)  LDD1663  [4]
 LDCM0463  CL70 HEK-293T C194(0.98)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C194(1.04)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C194(0.95)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C194(1.03)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C194(1.00)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C194(1.19)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C194(0.87)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C194(1.14)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C194(0.98)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C194(1.07)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C194(0.81)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C194(0.82)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C194(1.03)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C194(0.94)  LDD1685  [4]
 LDCM0485  CL90 HEK-293T C194(0.92)  LDD1688  [4]
 LDCM0487  CL92 HEK-293T C194(1.01)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C194(1.00)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C194(0.96)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C194(0.76)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C194(0.92)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C194(1.03)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C194(1.06)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C194(1.15)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C194(0.95)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C194(0.99); C297(1.03)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C194(1.05); C297(0.91)  LDD1497  [4]
 LDCM0024  KB05 Hs 936.T C82(2.53)  LDD3313  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965
E3 ubiquitin-protein ligase RNF144B (RNF144B) RBR family Q7Z419
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
E3 ubiquitin-protein ligase Itchy homolog (ITCH) . Q96J02
Histone acetyltransferase p300 (EP300) . Q09472
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor protein 63 (TP63) P53 family Q9H3D4
Tumor protein p73 (TP73) P53 family O15350
Runt-related transcription factor 2 (RUNX2) . Q13950
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Stress-70 protein, mitochondrial (HSPA9) Heat shock protein 70 family P38646
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
CASP8-associated protein 2 (CASP8AP2) . Q9UKL3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402