Details of the Target

General Information of Target

Target ID LDTP00607
Target Name DNA repair protein RAD51 homolog 2 (RAD51B)
Gene Name RAD51B
Gene ID 5890
Synonyms
RAD51L1; REC2; DNA repair protein RAD51 homolog 2; R51H2; RAD51 homolog B; Rad51B; RAD51-like protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELLCMVSRAC
APKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIM
MSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKVHLY
RELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREAS
SLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWA
PEILPPQPPEQLGLQMCHHTQLIF
Target Bioclass
Other
Family
RecA family, RAD51 subfamily
Subcellular location
Nucleus
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.
Uniprot ID
O15315
Ensemble ID
ENST00000460526.6
HGNC ID
HGNC:9822

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C54(2.85)  LDD3407  [1]
IA-alkyne
 Probe Info  		C185(6.82)  LDD1704  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C185(1.07); C16(0.93)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C16(1.08)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C185(0.97); C16(1.10); C54(0.98)  LDD1509  [4]
 LDCM0230  AC113 HEK-293T C54(0.76)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C54(0.87)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C54(0.82)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C54(0.99)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C54(0.75)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C54(0.81)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C54(1.11)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C16(1.15)  LDD1510  [4]
 LDCM0238  AC120 HEK-293T C54(1.05)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C54(0.89)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C54(0.84)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C54(1.13)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C54(1.03)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C54(1.16)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C54(1.25)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C54(1.18)  LDD0843  [5]
 LDCM0259  AC14 HEK-293T C185(0.89)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C185(0.90); C16(1.17)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C54(1.76)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C54(1.33)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C54(1.05)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C16(1.12)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C54(1.55)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C54(1.55)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C54(2.01)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C54(1.42)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C54(1.04)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C54(1.32)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C54(1.32)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C54(1.11)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C54(2.09)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C54(1.54)  LDD0887  [5]
 LDCM0290  AC3 HEK-293T C185(0.99); C16(0.96); C54(1.09)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C54(1.47)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C54(1.58)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C54(1.87)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C54(1.31)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C54(1.52)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C185(1.00); C16(0.94); C54(1.04)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C16(1.08)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C185(1.07); C16(1.19)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C185(0.99)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C185(1.25); C16(1.23)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C16(1.08)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C185(0.99); C16(0.90)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C185(1.13); C16(0.95)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C16(1.15)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C185(1.00); C16(0.97); C54(1.04)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C16(1.12)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C185(1.06); C16(1.11)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C54(0.83)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C54(0.98)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C54(0.68)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C54(0.95)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C185(0.88); C16(0.90)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C54(0.83)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C54(0.88)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C54(0.74)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C54(0.78)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C54(0.80)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C54(0.72)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C54(0.78)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C54(0.87)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C54(0.82)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C54(0.84)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C185(0.99)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C54(1.37)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C54(1.81)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C54(1.23)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C54(1.17)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C54(1.28)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C54(1.29)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C54(0.92)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C54(1.50)  LDD0929  [5]
 LDCM0332  AC68 HEK-293T C54(0.79)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C54(1.04)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C185(1.03); C16(1.14)  LDD1568  [4]
 LDCM0335  AC70 HEK-293T C54(0.93)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C54(0.86)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C54(0.97)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C54(0.87)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C54(0.85)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C54(0.79)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C54(0.75)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C54(0.91)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C54(0.83)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C54(0.95)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C185(1.06); C16(0.97)  LDD1569  [4]
 LDCM0346  AC80 HEK-293T C54(0.65)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C54(0.76)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C54(1.02)  LDD0946  [5]
 LDCM0349  AC83 HEK-293T C54(0.92)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C54(0.99)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C54(0.72)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C54(0.87)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C54(0.90)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C54(0.88)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C54(1.26)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C54(0.91)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C54(0.73)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C54(0.88)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C54(0.85)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C54(0.90)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C54(0.92)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C54(0.76)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C54(0.87)  LDD0962  [5]
 LDCM0248  AKOS034007472 HEK-293T C185(0.94); C16(1.03)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C185(0.82); C16(1.11)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C185(1.08); C16(1.02)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C185(0.94)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C185(1.25)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C185(1.00); C16(1.10)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C185(1.01)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C185(1.15)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C185(0.86); C16(1.00)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C185(1.48); C16(0.94)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C54(1.59)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C54(1.11)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C54(1.53)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C54(1.07)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C54(1.08)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C185(1.46); C16(1.15)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C54(1.16)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C54(2.39)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C54(1.30)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C54(1.30)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C54(2.46)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C54(2.03)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C54(1.62)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C185(1.09)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C185(0.97)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C185(0.93); C16(1.10)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C185(1.34); C16(1.09)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C185(1.22); C16(1.07)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C54(1.13)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C54(0.65)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C54(0.52)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C54(0.82)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C54(1.32)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C54(1.10)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C54(1.00)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C54(0.88)  LDD0997  [5]
 LDCM0400  CL13 HEK-293T C185(0.83)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C185(0.92)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C185(0.98); C16(1.19)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C185(1.05); C16(1.25)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C185(0.78); C16(1.03)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C16(1.19)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C185(1.08); C16(1.10); C54(1.01)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C185(1.06)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C16(1.10)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C185(1.18); C16(1.23)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C185(0.95)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C185(0.88); C16(1.05)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C185(1.24); C16(1.31)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C185(1.05)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C185(0.92)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C185(0.97); C16(1.11)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C185(1.08); C16(1.00)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C185(0.82); C16(1.11)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C185(0.93); C16(0.98)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C16(1.05)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C185(1.01); C16(1.01); C54(0.91)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C16(1.10)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C185(1.20); C16(1.05)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C185(1.24)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C185(1.19); C16(1.17)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C185(1.51); C16(1.29)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C185(1.00)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C185(1.26); C16(0.97)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C185(1.04); C16(1.13)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C185(1.21); C16(1.14)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C185(1.04); C16(1.09)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C16(1.07)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C185(1.01); C16(1.07); C54(0.95)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C16(1.19)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C185(1.13); C16(1.11)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C185(1.06)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C185(1.29); C16(1.08)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C185(1.40); C16(1.11)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C185(0.87)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C185(0.98); C16(1.08)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C185(1.08)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C185(1.32); C16(1.12)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C185(1.19); C16(1.12)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C16(1.21)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C185(1.00); C16(1.00); C54(1.00)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C16(1.18)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C185(1.14); C16(1.00)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C185(1.13)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C185(1.27); C16(1.22)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C16(1.05)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C185(1.17); C16(1.35)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C185(1.00)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C185(1.07)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C185(0.85); C16(1.28)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C185(1.35); C16(0.96)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C185(0.83); C16(1.13)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C16(1.12)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C185(1.06); C16(1.18); C54(1.04)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C16(1.02)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C185(1.25); C16(1.22)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C185(1.06); C16(1.02); C54(1.03)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C185(1.12)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C185(1.18); C16(1.20)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C185(1.13); C16(1.19)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C185(0.95)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C185(0.93)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C185(1.17); C16(1.13)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C185(1.00); C16(0.96)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C16(1.20)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C185(1.05); C16(1.03); C54(1.04)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C16(0.98)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C16(1.08)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C185(1.07); C16(1.08)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C185(1.03)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C185(1.05); C16(1.25)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C185(1.18); C16(1.05)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C185(0.94)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C185(1.00)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C185(1.08); C16(0.80)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C185(1.15); C16(1.03)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C185(0.83); C16(1.11)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C185(1.26); C16(1.09)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C16(1.06)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C185(1.12); C16(0.99); C54(1.02)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C16(1.08)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C185(1.09); C16(1.14)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C185(1.01)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C185(1.82); C16(1.50)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C185(1.24); C16(1.12)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C185(1.14)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C185(0.97)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C185(0.83); C16(0.90)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C185(0.93); C16(0.95)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C185(0.79); C16(1.06)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C185(0.97)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C185(0.64); C16(1.04); C54(1.06)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C185(0.78); C16(0.83); C54(0.97)  LDD1497  [4]
 LDCM0024  KB05 RKO C54(2.85)  LDD3407  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
DNA repair protein RAD51 homolog 3 (RAD51C) RecA family O43502
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
ATPase SWSAP1 (SWSAP1) . Q6NVH7
RPA-interacting protein (RPAIN) . Q86UA6

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.