Details of the Target

General Information of Target

Target ID LDTP00561
Target Name Axin-1 (AXIN1)
Gene Name AXIN1
Gene ID 8312
Synonyms
AXIN; Axin-1; Axis inhibition protein 1; hAxin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT
PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA
CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA
MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPT
LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP
VNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESV
QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEE
EGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR
TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVH
HSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGV
ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQ
PHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKR
ASRAPSKQRYVQEVMRRGRACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPC
DSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEV
REDEAVLPVFEEKIIGKVEKVD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation.
Uniprot ID
O15169
Ensemble ID
ENST00000262320.8
HGNC ID
HGNC:903
ChEMBL ID
CHEMBL1255127

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 Deletion: p.E640KfsTer65 DBIA    Probe Info 
HCC44 SNV: p.N605K DBIA    Probe Info 
HCT15 SNV: p.L396M .
HEP3B217 SNV: p.R146Ter .
HUH1 Deletion: p.R298_V301delinsL; p.N302PfsTer111 .
IM95 Deletion: p.G508VfsTer197
SNV: p.E31Ter		 .
Ishikawa (Heraklio) 02 ER SNV: p.S334P .
JHH6 Substitution: p.E5_Q6delinsDTer .
JURKAT SNV: p.R556H; p.A584V .
MCC13 SNV: p.P9S .
SHP77 SNV: p.T656S .
SNU423 Deletion: p.P345VfsTer65 .
SNU449 SNV: p.R712Ter .
TOV21G SNV: p.G521W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C451(1.02); C456(1.02)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		C221(0.00); C435(0.00); C45(0.00); C451(0.00)  LDD2156  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C130(1.00)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C833(1.03)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C130(0.83); C221(1.08)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C130(1.04)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C130(1.18)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C130(1.37)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C130(0.82)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C833(1.08)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C130(0.85); C221(1.55)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C833(1.22)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C130(1.09)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C130(1.03)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C130(1.08)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C130(1.24)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C130(1.02); C833(0.91)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C130(0.93)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C833(1.12)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C130(0.76); C221(1.12)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C130(1.03)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C130(0.90)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C130(0.83); C221(1.15)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C130(1.14)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C130(0.99)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C130(0.92); C833(1.04)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C130(0.85)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C833(1.08)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C130(0.69); C221(1.03)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C130(1.28)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C130(1.13)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C130(1.17)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C130(1.21)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C130(1.13)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C130(1.20); C833(0.95)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C130(0.87)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C833(1.09)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C130(0.97); C221(1.19)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C130(1.02)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C130(1.02)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C130(1.05)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C130(1.50)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C130(1.18); C833(0.96)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C130(0.84)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C130(1.11)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C833(1.02)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C130(0.90); C221(1.15)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C130(0.93)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C130(1.05)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C130(0.97)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C130(1.17)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C130(1.11); C833(0.98)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C130(0.86)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C833(1.16)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C130(0.88); C221(1.08)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C130(1.02)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C130(1.03)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C130(1.01)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C130(1.07)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C130(0.99)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C130(1.07); C833(0.90)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C130(0.97)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C130(1.12); C833(0.92)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C130(1.16)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C130(0.91)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C130(1.05); C833(0.94)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C451(1.02); C456(1.02)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C130(1.23)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C130(0.82)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C130(1.15)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C130(1.24)  LDD1574  [7]
 LDCM0372  CL103 HEK-293T C130(1.29)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C130(1.07)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C130(1.17)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C130(1.12)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C130(0.96)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C130(0.95)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C130(0.90)  LDD1583  [7]
 LDCM0381  CL111 HEK-293T C130(1.09)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C130(1.03)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C130(1.01)  LDD1587  [7]
 LDCM0385  CL115 HEK-293T C130(1.15)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C130(1.04)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C130(1.17)  LDD1591  [7]
 LDCM0389  CL119 HEK-293T C130(1.21)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C130(0.90); C833(1.03)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C130(1.10)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C130(1.24)  LDD1596  [7]
 LDCM0394  CL123 HEK-293T C130(1.01)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C130(1.14)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C130(1.23)  LDD1600  [7]
 LDCM0398  CL127 HEK-293T C130(1.16)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C130(1.05)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C130(1.25)  LDD1604  [7]
 LDCM0402  CL15 HEK-293T C130(1.06)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C130(1.11)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C130(0.97)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C833(1.03)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C130(1.01); C221(1.25)  LDD1610  [7]
 LDCM0408  CL20 HEK-293T C130(0.96)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C130(0.87)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C130(0.89)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C130(1.04)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C130(0.82); C833(0.98)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C130(1.06)  LDD1617  [7]
 LDCM0415  CL27 HEK-293T C130(1.15)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C130(1.09)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C130(0.89)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C130(1.11)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C833(1.04)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C130(0.93); C221(1.24)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C130(0.93)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C130(0.72)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C130(0.91)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C130(0.81)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C130(0.93); C833(0.89)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C130(1.12)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C130(1.08)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C130(1.04)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C130(0.98)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C130(0.87)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C833(1.00)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C130(0.83); C221(1.23)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C130(0.91)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C130(0.98)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C130(0.87)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C130(0.86)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C130(1.02); C833(1.00)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C130(1.18)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C130(0.98)  LDD1644  [7]
 LDCM0443  CL52 HEK-293T C130(1.19)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C130(0.97)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C833(1.11)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C130(0.80); C221(1.37)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C130(1.14)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C130(0.78)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C130(0.95)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C130(1.12)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C833(1.01)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C130(1.11); C833(1.09)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C130(1.10)  LDD1656  [7]
 LDCM0455  CL63 HEK-293T C130(1.28)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C130(1.03)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C130(1.08)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C833(1.08)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C130(0.97); C221(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C130(0.99)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C130(0.86)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C130(1.04); C221(1.16)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C130(0.95)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C130(1.10)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C130(0.83); C833(1.25)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C130(1.15)  LDD1669  [7]
 LDCM0469  CL76 HEK-293T C130(1.10)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C130(0.82)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C833(0.90)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C130(1.28); C221(1.13)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C130(0.78)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C130(0.95)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C130(0.94)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C130(0.85)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C130(0.91)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C130(0.90); C833(0.97)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C130(1.16)  LDD1682  [7]
 LDCM0481  CL87 HEK-293T C130(1.26)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C130(1.24)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C130(0.99)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C130(0.84)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C833(1.01)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C130(1.10); C221(1.34)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C130(0.87)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C130(0.86)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C130(0.88)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C130(0.82)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C130(0.84); C833(0.94)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C130(1.18)  LDD1695  [7]
 LDCM0494  CL99 HEK-293T C130(1.19)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C130(1.09)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C130(1.09)  LDD1671  [7]
 LDCM0022  KB02 HEK-293T C221(1.07); C130(0.86)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C221(1.01); C130(0.98)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1155 C602(5.10)  LDD3342  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Arkadia (RNF111) Arkadia family Q6ZNA4
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
Dihydropyrimidinase-related protein 1 (CRMP1) Hydantoinase/dihydropyrimidinase family Q14194
Protein phosphatase 1A (PPM1A) PP2C family P35813
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Casein kinase I isoform epsilon (CSNK1E) CK1 Ser/Thr protein kinase family P49674
Glycogen synthase kinase-3 alpha (GSK3A) CMGC Ser/Thr protein kinase family P49840
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM15 (TRIM15) TRIM/RBCC family Q9C019
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tripartite motif-containing protein 29 (TRIM29) . Q14134
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-arrestin-1 (ARRB1) Arrestin family P49407
MyoD family inhibitor (MDFI) MDFI family Q99750
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 7 (SMAD7) Dwarfin/SMAD family O15105
Homeobox protein TGIF1 (TGIF1) TALE/TGIF homeobox family Q15583
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Myc proto-oncogene protein (MYC) . P01106
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
APC membrane recruitment protein 1 (AMER1) Amer family Q5JTC6
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) ANP32 family P39687
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Junction plakoglobin (JUP) Beta-catenin family P14923
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Low-density lipoprotein receptor-related protein 6 (LRP6) LDLR family O75581
Syntaxin-11 (STX11) Syntaxin family O75558
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Tubulin gamma-1 chain (TUBG1) Tubulin family P23258
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Axin-1 (AXIN1) . O15169
F-box/WD repeat-containing protein 11 (FBXW11) . Q9UKB1
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
WD repeat-containing protein 26 (WDR26) . Q9H7D7

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
14-dithiothreitol Small molecular drug DB04447

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840