Details of the Target

General Information of Target

Target ID LDTP00534
Target Name Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)
Gene Name ANKRD28
Gene ID 23243
Synonyms
KIAA0379; Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; PP6-ARS-A; Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A; Ankyrin repeat domain-containing protein 28; Phosphatase interactor targeting protein hnRNP K; PITK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL
ILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV
KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA
AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN
TPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVN
MKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT
SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC
LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT
SDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD
MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD
VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS
VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR
TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV
FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ
LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK
GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY
TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN
EPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY
Target Bioclass
Other
Subcellular location
Nucleus, nucleoplasm
Function
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Uniprot ID
O15084
Ensemble ID
ENST00000399451.6
HGNC ID
HGNC:29024
ChEMBL ID
CHEMBL4105921

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K171(8.99)  LDD0277  [1]
m-APA
 Probe Info  		9.96  LDD0403  [2]
DBIA
 Probe Info  		C520(4.52); C505(2.89)  LDD3311  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C85(0.00); C122(0.00); C487(0.00); C701(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C122(0.00); C487(0.00); C701(0.00); C472(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C122(0.00); C472(0.00); C201(0.00); C898(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		C85(0.00); C122(0.00); C201(0.00); C334(0.00)  LDD2226  [7]
IPM
 Probe Info  		C898(0.00); C966(0.00); C487(0.00); C701(0.00)  LDD2156  [8]
Acrolein
 Probe Info  		C85(0.00); C701(0.00)  LDD0217  [9]
AOyne
 Probe Info  		12.20  LDD0443  [10]
NAIA_5
 Probe Info  		C85(0.00); C122(0.00); C701(0.00); C201(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C472(0.99); C701(1.04); C487(0.94); C966(1.12)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C472(1.01); C201(0.98); C701(0.99); C487(0.99)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C472(1.06); C201(1.09); C701(0.97); C487(0.99)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C472(1.03); C201(1.12); C701(1.01); C487(1.08)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C472(1.07); C201(1.02); C701(0.94); C487(0.96)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C472(1.00); C701(0.98); C487(0.86); C966(0.91)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C472(1.08); C701(0.98); C487(0.87); C966(1.00)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C472(0.98); C201(1.00); C701(1.07); C487(1.01)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C472(1.23); C201(0.81); C701(1.10); C487(1.11)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C472(1.08); C201(1.01); C701(1.05); C487(0.96)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C472(0.96); C201(1.05); C701(1.06); C487(1.03)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C472(1.09); C201(1.01); C701(1.04); C487(1.12)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C472(1.07); C201(1.14); C701(1.04); C487(0.97)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C472(0.97); C701(1.02); C487(0.95); C966(0.84)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C472(0.89); C201(0.96); C701(0.96); C487(1.07)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C472(1.04); C701(1.00); C487(0.87); C966(0.99)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C472(1.03); C201(0.99); C701(1.00); C487(0.98)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C472(1.11); C201(1.02); C701(0.99); C487(1.02)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C472(0.99); C201(1.12); C701(0.98); C487(0.97)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C472(1.06); C201(0.98); C701(1.02); C487(1.14)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C472(1.03); C201(1.17); C701(0.96); C487(1.08)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C472(0.99); C201(1.10); C701(0.98); C487(1.07)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C472(0.92); C701(1.01); C487(1.01); C966(0.86)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C472(1.03); C201(1.01); C701(1.05); C487(1.08)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C472(0.99); C701(1.09); C487(0.76); C966(0.97)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C472(1.06); C201(1.05); C701(1.03); C487(1.02)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C472(1.07); C201(1.15); C701(0.98); C487(1.02)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C472(1.08); C201(1.21); C701(1.06); C487(1.09)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C472(1.17); C201(1.09); C701(0.93); C487(1.16)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C472(1.07); C201(1.10); C701(0.94); C487(1.00)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C472(1.01); C701(1.03); C487(0.95); C966(0.83)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C472(1.01); C201(1.08); C701(1.02); C487(1.02)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C472(1.04); C201(1.07); C701(1.00); C487(1.10)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C472(1.03); C701(1.05); C487(0.92); C966(1.05)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C472(0.96); C201(1.24); C701(1.02); C487(0.99)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C472(1.10); C201(1.06); C701(0.95); C487(1.05)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C472(1.09); C201(1.13); C701(1.07); C487(1.04)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C472(0.99); C201(1.07); C701(0.98); C487(1.06)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C472(1.07); C201(1.11); C701(0.93); C487(1.06)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C472(1.00); C701(1.00); C487(0.93); C966(0.93)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C472(0.98); C201(1.08); C701(0.99); C487(1.06)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C472(1.04); C701(1.06); C487(0.98); C966(0.94)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C472(0.99); C201(1.12); C701(1.00); C487(1.12)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C472(1.03); C201(1.05); C701(1.00); C487(1.00)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C472(1.11); C201(1.09); C701(1.01); C487(1.11)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C472(0.99); C201(1.09); C701(1.01); C487(1.04)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C472(0.98); C201(1.06); C701(1.01); C487(1.15)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C472(0.95); C201(1.17); C701(0.94); C487(1.05)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C472(0.96); C701(0.99); C487(0.97); C966(0.76)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C472(0.93); C201(1.11); C701(0.97); C487(1.15)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C472(0.99); C701(1.07); C487(0.86); C966(1.09)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C472(1.05); C201(1.06); C701(1.11); C487(0.97)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C472(1.10); C201(1.11); C701(0.89); C487(1.06)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C472(1.03); C201(1.17); C701(1.01); C487(1.03)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C472(1.00); C201(1.13); C701(1.01); C487(1.06)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C472(0.96); C201(1.10); C701(1.01); C487(1.13)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C472(1.01); C201(1.08); C701(0.96); C487(1.03)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C472(0.89); C701(1.05); C487(0.93); C966(0.97)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C472(0.95); C201(1.06); C701(1.05); C487(1.04)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C472(1.00); C701(0.98); C487(1.01); C966(0.88)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C472(0.97); C201(1.04); C701(0.99); C487(1.01)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C472(0.95); C201(0.99); C701(0.95); C487(1.20)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C472(1.00); C701(1.04); C487(1.02); C966(1.03)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C472(0.95); C201(1.01); C701(0.99); C487(1.06)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 9.96  LDD0403  [2]
 LDCM0108  Chloroacetamide HeLa C701(0.00); C85(0.00)  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C85(0.96)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C472(1.08); C201(1.17); C701(1.00); C487(1.10)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C472(0.95); C201(0.89); C701(0.95); C487(1.07)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C472(0.98); C201(1.40); C701(0.86); C487(0.80)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C472(1.01); C201(1.04); C701(0.96); C487(1.08)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C472(0.87); C701(1.02); C487(1.06); C966(1.03)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C472(1.01); C701(1.01); C487(0.93); C966(0.93)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C472(1.04); C201(1.38); C701(0.99); C487(0.99)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C472(0.96); C201(0.98); C701(0.99); C487(1.17)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C472(1.02); C701(1.09); C487(1.37); C966(0.86)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C472(1.01); C701(0.94); C487(0.92); C966(0.94)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C472(0.97); C201(1.13); C701(0.96); C487(1.13)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C472(0.95); C201(1.08); C701(0.96); C487(0.96)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C472(0.95); C701(1.08); C487(0.99); C966(1.02)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C472(0.87); C701(1.11); C487(1.32); C966(0.85)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C472(1.06); C701(0.95); C487(0.99); C966(0.86)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C472(0.99); C201(1.14); C701(0.94); C487(0.82)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C472(1.13); C201(1.12); C701(1.00); C487(0.95)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C472(0.91); C701(1.04); C487(1.28); C966(0.98)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C472(1.04); C701(0.98); C487(0.91); C966(0.99)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C472(1.05); C201(1.50); C701(0.99); C487(1.04)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C472(0.99); C201(1.01); C701(1.02); C487(0.94)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C472(1.04); C701(1.08); C487(1.26); C966(0.89)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C472(1.00); C701(0.95); C487(0.93); C966(1.09)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C472(0.89); C201(1.00); C701(0.94); C487(1.01)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C472(1.11); C201(1.52); C701(0.93); C487(0.87)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C472(0.98); C201(1.03); C701(1.02); C487(1.00)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C472(0.99); C701(1.01); C487(1.49); C966(0.94)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C472(0.96); C701(1.00); C487(0.99); C966(0.87)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C472(1.02); C201(1.30); C701(0.95); C487(1.27)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C472(0.96); C201(1.22); C701(1.01); C487(1.10)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C472(0.99); C701(1.07); C487(1.02); C966(0.93)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C472(1.10); C701(1.00); C487(0.96); C966(1.03)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C472(0.98); C201(1.57); C701(0.93); C487(0.92)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C472(1.10); C201(1.13); C701(0.99); C487(0.94)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C472(1.03); C701(1.05); C487(1.07); C966(0.99)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C472(1.03); C701(1.06); C487(0.96); C966(0.94)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C472(1.11); C201(1.43); C701(0.94); C487(1.02)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C472(0.95); C701(0.97); C487(0.88); C966(1.18)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C472(1.07); C201(1.16); C701(1.14); C487(0.95)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C472(1.18); C201(0.94); C701(0.96); C487(1.05)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C472(1.13); C701(0.98); C487(1.04); C966(0.99)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C472(0.97); C201(1.00); C701(1.01); C487(1.07)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C472(1.06); C201(0.98); C701(0.55); C487(1.32)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C472(1.08); C201(0.96); C701(0.99); C487(0.96)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C472(0.96); C701(1.00); C487(0.86); C966(0.87)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C472(0.96); C201(1.04); C701(1.03); C487(1.02)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C472(0.99); C201(1.18); C701(0.95); C487(0.94)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C472(1.10); C701(0.99); C487(0.95); C966(0.87)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C472(1.08); C701(0.98); C487(0.92); C966(0.93)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C472(1.00); C201(1.24); C701(0.95); C487(0.92)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C472(1.03); C701(1.03); C487(0.81); C966(0.92)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C472(1.12); C701(1.00); C487(0.89); C966(1.12)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C472(1.09); C201(1.03); C701(1.03); C487(1.00)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C472(1.04); C201(0.96); C701(1.01); C487(0.96)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C472(1.00); C201(1.01); C701(0.98); C487(1.02)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C472(0.91); C201(0.90); C701(1.09); C487(1.23)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C472(0.96); C201(0.90); C701(1.02); C487(0.99)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C472(0.94); C701(1.04); C487(0.86); C966(0.86)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C472(0.97); C201(1.00); C701(0.99); C487(0.99)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C472(1.04); C201(1.11); C701(1.04); C487(0.84)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C472(1.05); C701(0.96); C487(0.89); C966(0.88)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C472(1.12); C201(1.44); C701(0.93); C487(1.02)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C472(1.03); C201(1.27); C701(0.96); C487(0.85)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C472(0.98); C701(1.03); C487(0.93); C966(1.04)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C472(1.03); C201(1.15); C701(1.02); C487(1.07)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C472(1.00); C201(0.96); C701(1.08); C487(0.90)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C472(1.00); C201(1.01); C701(1.00); C487(0.98)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C472(1.00); C201(0.90); C701(0.94); C487(1.22)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C472(1.01); C201(0.95); C701(0.97); C487(0.99)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C472(0.97); C701(1.05); C487(0.87); C966(1.00)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C472(0.95); C201(0.97); C701(0.96); C487(1.06)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C472(1.04); C201(1.31); C701(0.98); C487(0.89)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C472(1.03); C701(1.05); C487(0.82); C966(1.13)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C472(0.96); C701(1.04); C487(1.23); C966(0.89)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C472(1.01); C201(1.43); C701(1.02); C487(0.98)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C472(0.95); C701(1.14); C487(1.00); C966(0.99)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C472(1.05); C201(1.23); C701(1.08); C487(0.61)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C472(1.09); C201(1.06); C701(1.08); C487(0.92)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C472(1.10); C201(1.08); C701(1.02); C487(1.04)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C472(1.10); C201(0.97); C701(1.01); C487(1.22)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C472(0.98); C201(0.98); C701(1.01); C487(1.04)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C472(0.92); C701(1.03); C487(0.94); C966(0.68)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C472(1.02); C201(1.08); C701(1.11); C487(0.98)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C472(0.93); C201(0.99); C701(0.91); C487(1.00)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C472(1.04); C201(1.16); C701(1.02); C487(0.99)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C472(0.97); C701(1.02); C487(1.19); C966(1.05)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C472(1.06); C701(0.98); C487(0.87); C966(0.93)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C472(1.10); C201(1.39); C701(0.99); C487(1.22)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C472(1.07); C701(1.07); C487(0.80); C966(1.01)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C472(1.11); C201(1.28); C701(1.02); C487(0.95)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C472(1.11); C201(0.99); C701(1.03); C487(0.93)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C472(0.96); C201(1.07); C701(1.03); C487(1.11)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C472(0.91); C201(1.03); C701(0.95); C487(1.17)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C472(1.25); C201(0.98); C701(1.01); C487(0.99)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C472(1.05); C201(0.95); C701(1.01); C487(0.99)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C472(1.01); C701(0.96); C487(1.09); C966(0.77)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C472(1.04); C201(1.03); C701(0.96); C487(1.05)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C472(0.94); C201(1.11); C701(0.96); C487(1.28)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C472(0.99); C701(1.08); C487(1.36); C966(0.89)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C472(1.03); C201(1.32); C701(0.93); C487(0.79)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C472(0.97); C701(1.06); C487(1.06); C966(1.03)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C472(1.00); C201(1.02); C701(1.08); C487(1.02)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C472(1.25); C201(1.01); C701(0.96); C487(1.01)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C472(0.99); C201(1.00); C701(1.27); C487(1.14)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C472(0.93); C201(1.09); C701(0.99); C487(1.05)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C472(0.96); C201(0.93); C701(0.99); C487(1.17)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C472(1.06); C201(0.99); C701(0.98); C487(1.02)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C472(0.93); C701(1.00); C487(0.86); C966(0.90)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C472(0.89); C201(1.03); C701(1.02); C487(1.06)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C472(1.02); C201(1.38); C701(1.12); C487(1.00)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C472(0.96); C701(1.00); C487(1.05); C966(0.98)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C472(1.03); C701(0.96); C487(0.98); C966(1.12)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C472(1.01); C201(1.80); C701(0.90); C487(0.89)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C472(0.96); C701(1.07); C487(0.93); C966(1.13)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C472(1.02); C201(1.00); C701(1.02); C487(1.07)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C472(0.88); C201(1.14); C701(1.26); C487(1.24)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C472(1.10); C201(1.16); C701(1.11); C487(1.02)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C472(0.97); C201(1.18); C701(1.07); C487(1.12)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C472(1.01); C201(1.06); C701(1.01); C487(1.26)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C472(0.97); C201(1.02); C701(0.99); C487(1.04)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C472(1.04); C701(1.11); C487(1.04); C966(1.22)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C472(0.90); C201(1.04); C701(1.08); C487(1.09)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C472(1.02); C201(1.05); C701(1.00); C487(1.25)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C472(1.03); C701(1.11); C487(1.13); C966(0.99)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C472(1.03); C701(1.03); C487(0.91); C966(1.04)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C472(1.00); C701(0.90); C487(0.85); C966(0.92)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C472(1.05); C701(1.02); C487(0.93); C966(0.93)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C472(0.96); C701(0.99); C487(1.02); C966(0.97)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C632(1.05); C472(1.04); C701(0.93); C334(0.86)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C632(0.89); C472(1.10); C701(0.99); C334(0.98)  LDD1497  [11]
 LDCM0024  KB05 G361 C520(4.52); C505(2.89)  LDD3311  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) PPP phosphatase family O00743
Peptidyl-tRNA hydrolase (PTRH1) PTH family Q86Y79
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Potassium voltage-gated channel subfamily V member 2 (KCNV2) Potassium channel family Q8TDN2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 7 (THAP7) . Q9BT49
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dedicator of cytokinesis protein 1 (DOCK1) DOCK family Q14185
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Protein INCA1 (INCA1) INCA family Q0VD86
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Serine/threonine-protein phosphatase 6 regulatory subunit 1 (PPP6R1) SAPS family Q9UPN7
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (PPP6R2) SAPS family O75170
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) SAPS family Q5H9R7
YTH domain-containing protein 1 (YTHDC1) . Q96MU7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402