Details of the Target

General Information of Target

Target ID LDTP00525
Target Name Zinc finger and BTB domain-containing protein 5 (ZBTB5)
Gene Name ZBTB5
Gene ID 9925
Synonyms
KIAA0354; Zinc finger and BTB domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFSVAEGDQ
TMNMIQLDSEVVTAEAFAALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLT
TRTLPMSPPSERVQEQSARMQRSFMLQQLGLSIVSSALNSSQNGEEQPAPMSSSMRSNLD
QRTPFPMRRLHKRKQSAEERARQRLRPSIDESAISDVTPENGPSGVHSREEFFSPDSLKI
VDNPKADGMTDNQEDSAIMFDQSFGTQEDAQVPSQSDNSAGNMAQLSMASRATQVETSFD
QEAAPEKSSFQCENPEVGLGEKEHMRVVVKSEPLSSPEPQDEVSDVTSQAEGSESVEVEG
VVVSAEKIDLSPESSDRSFSDPQSSTDRVGDIHILEVTNNLEHKSTFSISNFLNKSRGNN
FTANQNNDDNIPNTTSDCRLESEAPYLLSPEAGPAGGPSSAPGSHVENPFSEPADSHFVR
PMQEVMGLPCVQTSGYQGGEQFGMDFSRSGLGLHSSFSRVMIGSPRGGASNFPYYRRIAP
KMPVVTSVRSSQIPENSTSSQLMMNGATSSFENGHPSQPGPPQLTRASADVLSKCKKALS
EHNVLVVEGARKYACKICCKTFLTLTDCKKHIRVHTGEKPYACLKCGKRFSQSSHLYKHS
KTTCLRWQSSNLPSTLL
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
O15062
Ensemble ID
ENST00000307750.5
HGNC ID
HGNC:23836

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C312(3.43)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C312(0.99)  LDD1509  [2]
 LDCM0230  AC113 HEK-293T C438(0.93)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C438(0.95)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C438(1.11)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C438(0.92)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C438(0.63)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C438(0.69)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C438(0.75)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C312(1.04)  LDD1510  [2]
 LDCM0238  AC120 HEK-293T C438(1.33)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C438(0.79)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C438(0.50)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C438(0.47)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C438(0.79)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C438(0.50)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C438(0.36)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C438(0.28)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C438(0.97)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C438(1.13)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C438(1.11)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C438(0.73)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C438(1.07)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C438(1.12)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C438(1.17)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C438(1.28)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C438(1.20)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C438(1.04)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C438(1.07)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C438(0.88)  LDD0856  [3]
 LDCM0260  AC140 HEK-293T C438(1.26)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C438(1.30)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C438(1.16)  LDD0860  [3]
 LDCM0270  AC15 HEK-293T C312(1.04)  LDD1513  [2]
 LDCM0278  AC19 HEK-293T C312(1.01)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C312(0.99)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C312(0.98)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C312(1.01)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C312(1.61)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C438(1.00)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C438(0.94)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C438(0.98)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C438(0.95)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C438(1.01)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C312(0.86)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C438(1.12)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C438(1.10)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C438(1.05)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C438(1.06)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C438(1.07)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C312(0.88)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C312(0.95)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C312(0.98)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C312(1.10)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C312(1.02)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C312(0.96)  LDD1541  [2]
 LDCM0305  AC43 HEK-293T C312(0.95)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C312(1.13)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C312(1.02)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C312(1.11)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C312(0.88)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C312(0.98)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C312(1.07)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C312(0.94)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C312(1.04)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C312(0.97)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C312(1.09)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C438(1.03)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C438(1.07)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C438(0.97)  LDD0920  [3]
 LDCM0324  AC60 HEK-293T C438(1.09)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C438(0.84)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C438(0.95)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C438(0.84)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C438(0.98)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C438(0.85)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C438(1.00)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C438(0.96)  LDD0929  [3]
 LDCM0334  AC7 HEK-293T C312(0.95)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C312(1.10)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C312(0.89)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C312(0.92)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C312(0.91)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C312(0.91)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C312(1.07)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C312(0.97)  LDD1575  [2]
 LDCM0373  CL104 HEK-293T C312(1.01)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C312(0.98)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C312(0.98)  LDD1579  [2]
 LDCM0377  CL108 HEK-293T C312(0.94)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C312(0.88)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C312(1.00)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C312(0.96)  LDD1584  [2]
 LDCM0382  CL112 HEK-293T C438(0.97)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C438(0.97)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C438(0.76)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C438(0.99)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C438(1.01)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C312(0.92)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C312(1.06)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C312(1.07)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C312(1.05)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C312(1.00)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C312(0.98)  LDD1597  [2]
 LDCM0395  CL124 HEK-293T C312(1.00)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C438(0.91)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C438(0.94)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C438(1.13)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C438(0.98)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C312(0.91)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C312(1.06)  LDD1605  [2]
 LDCM0403  CL16 HEK-293T C312(1.02)  LDD1607  [2]
 LDCM0406  CL19 HEK-293T C312(0.96)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C312(1.05)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C312(1.13)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C312(0.87)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C312(1.05)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C312(1.20)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C312(0.90)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C312(1.07)  LDD1618  [2]
 LDCM0416  CL28 HEK-293T C312(1.10)  LDD1620  [2]
 LDCM0420  CL31 HEK-293T C312(0.84)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C312(1.08)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C312(0.73)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C312(1.08)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C312(1.09)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C312(0.87)  LDD1630  [2]
 LDCM0429  CL4 HEK-293T C312(1.09)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C312(1.11)  LDD1634  [2]
 LDCM0433  CL43 HEK-293T C312(0.92)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C312(1.03)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C312(0.94)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C312(1.05)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C312(1.26)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C312(0.97)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C312(1.09)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C312(0.97)  LDD1646  [2]
 LDCM0446  CL55 HEK-293T C312(0.95)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C312(1.03)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C312(0.98)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C312(1.18)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C312(1.12)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C312(0.91)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C312(1.16)  LDD1657  [2]
 LDCM0456  CL64 HEK-293T C312(1.17)  LDD1659  [2]
 LDCM0459  CL67 HEK-293T C312(0.97)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C312(1.10)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C312(1.00)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C312(0.96)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C312(1.10)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C312(0.99)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C312(0.94)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C312(1.09)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C312(0.93)  LDD1672  [2]
 LDCM0472  CL79 HEK-293T C312(0.89)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C312(0.79)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C312(0.99)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C312(0.98)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C312(0.94)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C312(1.20)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C312(0.97)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C312(0.97)  LDD1683  [2]
 LDCM0482  CL88 HEK-293T C312(0.98)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C312(0.99)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C312(1.00)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C312(0.98)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C312(0.93)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C312(1.00)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C312(1.77)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C312(1.07)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C312(1.07)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C312(0.99)  LDD1631  [2]
 LDCM0022  KB02 A-549 C312(1.60)  LDD2260  [1]
 LDCM0023  KB03 A204 C312(1.65)  LDD2669  [1]
 LDCM0024  KB05 NB1 C312(3.43)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.