Details of the Target

General Information of Target

Target ID LDTP00499
Target Name Zinc finger protein 263 (ZNF263)
Gene Name ZNF263
Gene ID 10127
Synonyms
FPM315; ZKSCAN12; Zinc finger protein 263; Zinc finger protein FPM315; Zinc finger protein with KRAB and SCAN domains 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGPGSQEREGLLIVKLEEDCAWSQELPPPDPGPSPEASHLRFRRFRFQEAAGPREALS
RLQELCHGWLRPEMRTKEQILELLVLEQFLTILPQEIQSRVQELHPESGEEAVTLVEDMQ
RELGRLRQQVTNHGRGTEVLLEEPLPLETARESPSFKLEPMETERSPGPRLQELLGPSPQ
RDPQAVKERALSAPWLSLFPPEGNMEDKEMTGPQLPESLEDVAMYISQEEWGHQDPSKRA
LSRDTVQESYENVDSLESHIPSQEVPGTQVGQGGKLWDPSVQSCKEGLSPRGPAPGEEKF
ENLEGVPSVCSENIHPQVLLPDQARGEVPWSPELGRPHDRSQGDWAPPPEGGMEQALAGA
SSGRELGRPKELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMGVDCTEIFGGNPR
FLSLHRAHLGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNICGKCFSCNSNLHRH
QRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCPECGKSFSRSSHLVIHERTH
ERERLYPFSECGEAVSDSTPFLTNHGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTHTGE
KPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYK
CSECGESFSRSSRLMSHQRTHTG
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor. Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression. Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions.
Uniprot ID
O14978
Ensemble ID
ENST00000219069.6
HGNC ID
HGNC:13056

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C406(1.08); C411(1.08)  LDD0531  [1]
CY4
 Probe Info  		C467(0.00); Y462(0.00)  LDD0247  [2]
HHS-465
 Probe Info  		K488(0.00); K491(0.00); Y490(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C406(1.08); C411(1.08)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C406(1.06)  LDD0813  [1]
 LDCM0226  AC11 HEK-293T C406(1.04)  LDD0824  [1]
 LDCM0230  AC113 HEK-293T C406(1.02)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C406(0.87)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C406(1.04)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C406(1.08)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C406(1.47)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C406(1.33)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C406(1.07)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C406(1.13)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C406(1.50)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C406(1.13)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C406(1.14)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C406(1.53)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C406(1.14)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C406(1.18)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C406(1.39)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C406(1.67)  LDD0843  [1]
 LDCM0259  AC14 HEK-293T C406(1.59)  LDD0857  [1]
 LDCM0263  AC143 HCT 116 C406(1.09); C411(1.09)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C411(1.54); C406(1.54)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C406(0.98); C411(0.98)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C406(1.27); C411(1.33)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C411(1.22); C406(1.25)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C406(1.46); C411(1.65)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C406(1.10); C411(1.24)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C406(1.09)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C406(1.02); C411(1.13)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C406(1.30); C411(1.36)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C406(1.32); C411(1.33)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C406(1.38); C411(1.48)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C406(1.30); C411(1.31)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C406(1.22); C411(1.30)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C406(1.24); C411(1.31)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C406(1.10); C411(1.24)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C406(1.86); C411(1.86)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C406(0.78); C411(0.78)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C406(1.38); C411(1.38)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C406(1.28); C411(1.28)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C406(1.61); C411(1.61)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C406(1.17); C411(1.17)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C406(0.88); C411(0.88)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C406(1.30); C411(1.30)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C406(1.30); C411(1.30)  LDD0601  [1]
 LDCM0290  AC3 HCT 116 C406(1.13); C411(1.13)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C406(1.11); C411(1.11)  LDD0618  [1]
 LDCM0308  AC46 HCT 116 C406(1.10); C411(1.10)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C406(0.89); C411(0.89)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C406(0.85); C411(0.85)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C406(1.15); C411(1.15)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C406(1.12); C411(1.12)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C406(1.01); C411(1.01)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C406(1.02); C411(1.02)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C406(0.96); C411(0.96)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C406(1.04); C411(1.04)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C406(0.82); C411(0.82)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C406(0.99); C411(0.99)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C406(0.90); C411(0.90)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C406(1.03); C411(1.03)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C406(1.34); C411(1.34)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C406(1.23); C411(1.23)  LDD0639  [1]
 LDCM0323  AC6 HEK-293T C406(1.14)  LDD0921  [1]
 LDCM0324  AC60 HCT 116 C406(1.46); C411(1.46)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C406(1.15); C411(1.15)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C406(1.36); C411(1.36)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C406(1.64); C411(1.64)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C406(1.43); C411(1.43)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C406(1.38); C411(1.38)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C406(1.43); C411(1.43)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C406(1.37); C411(1.37)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C406(1.09); C411(1.09)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C406(1.12); C411(1.12)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C406(1.13)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C406(0.90); C411(0.90)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C406(0.86); C411(0.86)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C406(1.02); C411(1.02)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C406(1.10); C411(1.10)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C406(1.22); C411(1.22)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C406(1.16); C411(1.16)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C406(1.00); C411(1.00)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C406(1.04); C411(1.04)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C406(1.10); C411(1.10)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C406(1.15); C411(1.15)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C406(1.11)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C406(0.99); C411(0.99)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C406(0.86); C411(0.86)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C406(1.00); C411(1.00)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C406(1.28); C411(1.28)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C406(1.15); C411(1.15)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C406(1.06); C411(1.06)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C406(1.09); C411(1.09)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C406(1.05); C411(1.05)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C406(0.83); C411(0.83)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C406(1.24); C411(1.24)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C406(1.00); C411(1.00)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C406(1.17); C411(1.17)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C406(1.26); C411(1.26)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C406(1.09); C411(1.09)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C406(1.23); C411(1.23)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C406(1.01); C411(1.01)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C406(1.26); C411(1.26)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C406(1.17); C411(1.17)  LDD0962  [1]
 LDCM0248  AKOS034007472 HEK-293T C406(1.33)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C406(1.49)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C406(1.28)  LDD0873  [1]
 LDCM0369  CL100 HCT 116 C406(1.09); C411(1.09)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C406(1.78)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C406(1.69)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C406(1.21)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C406(1.03)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C406(2.06); C411(2.06)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C406(2.08); C411(2.08)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C406(1.94); C411(1.94)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C406(1.42); C411(1.42)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C406(1.49); C411(1.49)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C406(1.78); C411(1.78)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C406(1.26); C411(1.26)  LDD0698  [1]
 LDCM0392  CL121 HCT 116 C406(1.00); C411(1.00)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C406(0.91); C411(0.91)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C406(0.71); C411(0.71)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C406(0.98); C411(0.98)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C406(1.23); C411(1.23)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C406(1.13); C411(1.13)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C406(1.35); C411(1.35)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C406(1.16); C411(1.16)  LDD0716  [1]
 LDCM0436  CL46 HCT 116 C406(0.82); C411(0.82)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C406(1.02); C411(1.02)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C406(2.04); C411(2.04)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C406(1.74); C411(1.74)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C406(1.48); C411(1.48)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C406(1.81); C411(1.81)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C406(1.43); C411(1.43)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C406(1.24); C411(1.24)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C406(1.05); C411(1.05)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C406(1.05); C411(1.05)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C406(1.32); C411(1.32)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C406(1.21); C411(1.21)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C406(1.60); C411(1.60)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C406(2.24); C411(2.24)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C406(1.47); C411(1.47)  LDD0769  [1]
 LDCM0486  CL91 HCT 116 C406(0.99); C411(0.99)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C406(0.96); C411(0.96)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C406(0.81); C411(0.81)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C406(1.13); C411(1.13)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C406(1.03); C411(1.03)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C406(1.27); C411(1.27)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C406(1.28); C411(1.28)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C406(0.95); C411(0.95)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C406(0.94); C411(0.94)  LDD0811  [1]
 LDCM0022  KB02 ICC26 C442(1.57)  LDD2390  [4]
 LDCM0023  KB03 ICC3 C442(2.06)  LDD2808  [4]
 LDCM0024  KB05 ICC26 C442(1.66)  LDD3224  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger protein 165 (ZNF165) Krueppel C2H2-type zinc-finger protein family P49910
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
Periplakin (PPL) Plakin or cytolinker family O60437
TRPM8 channel-associated factor 1 (TCAF1) TCAF family Q9Y4C2
G patch domain-containing protein 2-like (GPATCH2L) . Q9NWQ4
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840