Details of the Target

General Information of Target

Target ID LDTP00382
Target Name Cdc42 effector protein 2 (CDC42EP2)
Gene Name CDC42EP2
Gene ID 10435
Synonyms
BORG1; CEP2; Cdc42 effector protein 2; Binder of Rho GTPases 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTKVPIYLKRGSRKGKKEKLRDLLSSDMISPPLGDFRHTIHIGSGGGSDMFGDISFLQG
KFHLLPGTMVEGPEEDGTFDLPFQFTRTATVCGRELPDGPSPLLKNAISLPVIGGPQALT
LPTAQAPPKPPRLHLETPQPSPQEGGSVDIWRIPETGSPNSGLTPESGAEEPFLSNASSL
LSLHVDLGPSILDDVLQIMDQDLDSMQIPT
Target Bioclass
Other
Family
BORG/CEP family
Subcellular location
Endomembrane system
Function
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
Uniprot ID
O14613
Ensemble ID
ENST00000279249.3
HGNC ID
HGNC:16263

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K10(6.23)  LDD0277  [1]
BTD
 Probe Info  		C92(0.52)  LDD2089  [2]
DBIA
 Probe Info  		C92(1.08)  LDD0580  [3]
ENE
 Probe Info  		N.A.  LDD0006  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C92(0.52)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C92(1.16)  LDD2130  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C92(0.77)  LDD2131  [2]
 LDCM0263  AC143 HCT 116 C92(1.08)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C92(1.56)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C92(1.21)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C92(1.25)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C92(1.33)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C92(1.43)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C92(1.43)  LDD0586  [3]
 LDCM0271  AC150 HCT 116 C92(1.04)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C92(1.01)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C92(1.44)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C92(2.20)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C92(0.98)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C92(1.49)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C92(1.84)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C92(1.25)  LDD2161  [3]
 LDCM0285  AC25 HCT 116 C92(1.36)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C92(1.35)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C92(1.28)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C92(1.06)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C92(1.18)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C92(1.25)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C92(2.15)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C92(1.82)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C92(1.32)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C92(1.29)  LDD0612  [3]
 LDCM0320  AC57 HCT 116 C92(0.94)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C92(0.91)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C92(1.11)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C92(0.86)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C92(0.95)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C92(1.18)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C92(0.94)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C92(0.89)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C92(1.04)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C92(0.98)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C92(0.98)  LDD0648  [3]
 LDCM0545  Acetamide MDA-MB-231 C92(0.48)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C92(0.86)  LDD2113  [2]
 LDCM0498  BS-3668 MDA-MB-231 C92(0.35)  LDD2091  [2]
 LDCM0382  CL112 HCT 116 C92(1.02)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C92(1.31)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C92(1.57)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C92(1.53)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C92(1.81)  LDD0703  [3]
 LDCM0396  CL125 HCT 116 C92(1.12)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C92(0.95)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C92(1.03)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C92(1.18)  LDD0716  [3]
 LDCM0436  CL46 HCT 116 C92(1.50)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C92(1.06)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C92(1.19)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C92(1.21)  LDD0756  [3]
 LDCM0441  CL50 HCT 116 C92(0.99)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C92(1.20)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C92(1.47)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C92(0.97)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C92(1.08)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C92(0.85)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C92(0.88)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C92(0.86)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C92(1.15)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C92(1.13)  LDD0767  [3]
 LDCM0452  CL60 HCT 116 C92(1.23)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C92(0.77)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C92(0.97)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C92(0.92)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C92(0.91)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C92(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C92(1.19)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C92(1.09)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C92(0.85)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C92(1.18)  LDD0778  [3]
 LDCM0463  CL70 HCT 116 C92(1.04)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C92(1.10)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C92(0.95)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C92(1.09)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C92(1.18)  LDD0784  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(2.09)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C92(0.99)  LDD0785  [3]
 LDCM0022  KB02 786-O C92(1.99)  LDD2247  [6]
 LDCM0023  KB03 MDA-MB-231 C92(5.43)  LDD1701  [2]
 LDCM0024  KB05 RAW264.7 C92(2.87)  LDD3329  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C92(0.44)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C92(0.52)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C92(0.86)  LDD2093  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C92(1.42)  LDD2097  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C92(0.78)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C92(0.71)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C92(0.45)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C92(0.86)  LDD2111  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C92(0.75)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C92(0.72)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C92(0.83)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C92(0.74)  LDD2129  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C92(1.01)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C92(0.94)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C92(0.56)  LDD2140  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C92(1.54)  LDD2143  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C92(0.34)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Cell division control protein 42 homolog (CDC42) Rho family P60953
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) Cytochrome c oxidase subunit 5B family P10606
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PRKCA-binding protein (PICK1) . Q9NRD5
Rho GTPase-activating protein 26 (ARHGAP26) . Q9UNA1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840