Details of the Target

General Information of Target

Target ID LDTP00342
Target Name Acetyl-CoA carboxylase 2 (ACACB)
Gene Name ACACB
Gene ID 32
Synonyms
ACC2; ACCB; Acetyl-CoA carboxylase 2; EC 6.4.1.2; ACC-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQR
NGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGT
GTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV
AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHR
DFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVT
PEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL
PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGK
RISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQV
QSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP
LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNL
PAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDE
GFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA
LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGAL
NVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIM
NGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP
SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVAR
LELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIK
LKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP
SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRV
EHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSD
ELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP
ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCV
VEFQFMLPSSHPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTR
NFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVP
ILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQL
ELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKEASFEY
LQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEESVRYMVMRYGS
RLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSF
GNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPK
DILTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIG
SFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFK
YLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSL
AYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQL
GGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSR
APYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVE
TRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAVKDFNREKLPLMIFANWRGF
SGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYAELRGGSWVVIDATINPLCIEMYA
DKESRGGVLEPEGTVEIKFRKKDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLK
AREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVK
QEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRSTIR
ENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSPAST
Target Type
Successful
Target Bioclass
Enzyme
Subcellular location
Mitochondrion
Function
Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism . Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation. Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage.
TTD ID
T08922
Uniprot ID
O00763
DrugMap ID
TTY84UG
Ensemble ID
ENST00000338432.12
HGNC ID
HGNC:85
ChEMBL ID
CHEMBL4829

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R2360H .
8305C SNV: p.V1533A .
CCK81 SNV: p.E1436D .
CMK Substitution: p.G1858K .
COLO792 SNV: p.G2095R DBIA    Probe Info 
DOTC24510 SNV: p.A902V DBIA    Probe Info 
FTC133 SNV: p.R1706Q .
HCC1419 SNV: p.D414N .
HCT15 SNV: p.R1890I; p.W2078C .
IGROV1 Deletion: p.L1398SfsTer26 .
IM95 Deletion: p.L1398SfsTer26 .
IPC298 SNV: p.P638L; p.L1398F DBIA    Probe Info 
KMRC20 SNV: p.R615Q .
KYSE150 Substitution: p.S200C DBIA    Probe Info 
KYSE410 SNV: p.G2090E .
KYSE510 SNV: p.I484V DBIA    Probe Info 
LN18 SNV: p.S522C .
MCC13 SNV: p.K823Ter; p.S1408F; p.P2395S .
MDAMB453 SNV: p.F287L .
MDST8 SNV: p.Q2187H DBIA    Probe Info 
MEWO SNV: p.L1569V; p.P2038S .
MFE319 SNV: p.L1808P .
MIAPACA2 SNV: p.M2152I .
NCIH1299 SNV: p.D1383Y .
NCIH2291 SNV: p.A507P .
NCIH23 SNV: p.D1736N
Substitution: p.N307_A308delinsKP		 .
NUGC3 SNV: p.G1689R .
OVCAR8 SNV: p.Y877Ter .
PF382 SNV: p.P612L .
RVH421 Deletion: p.V336PfsTer17 DBIA    Probe Info 
SHSY5Y SNV: p.D757Y .
TFK1 SNV: p.E1924K .
TOV21G Deletion: p.I2092FfsTer5 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1412(1.72)  LDD0080  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C365(0.98); C1259(0.82)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C365(1.01)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C365(0.89)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C365(0.83)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C365(0.96)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C365(0.98); C1259(1.07)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C365(1.03); C1259(1.01)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C365(0.99)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C365(0.91)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C365(1.06)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C365(0.79)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C365(1.17)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C365(0.92)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C365(0.98); C1259(1.05)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C365(1.08)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C365(1.12); C1259(0.89)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C365(1.00)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C365(0.84)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C365(0.99)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C365(0.88)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C365(0.86)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C365(0.92)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C365(1.14); C1259(0.99)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C365(1.02)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C365(1.16); C1259(0.92)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C365(0.98)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C365(1.00)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C365(0.85)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C365(1.00)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C365(0.95)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C365(1.14); C1259(0.89)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C365(0.81)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C365(0.82)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C365(1.06); C1259(0.96)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C365(0.89)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C365(0.84)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C365(0.98)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C365(1.11)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C365(0.93)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C365(1.14); C1259(1.14)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C365(1.01)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C365(0.98); C1259(0.88)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C365(0.98)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C365(1.05)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C365(1.04)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C365(0.87)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C365(1.01)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C365(1.05)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C365(0.99); C1259(1.15)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C365(0.87)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C365(1.22); C1259(0.97)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C365(1.09)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C365(0.90)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C365(1.03)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C365(0.78)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C365(0.97)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C365(1.15)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C365(0.89); C1259(1.06)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C365(0.90)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C365(1.15); C1259(1.03)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C365(0.87)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C365(1.03)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C365(1.00); C1259(0.92)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C365(0.85)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C365(0.88)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C365(0.95)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C365(0.93)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C365(0.94)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C365(0.90)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C365(0.89)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C365(0.97)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C365(0.89)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C365(1.38)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C365(0.87)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C365(1.05)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C365(0.97)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C365(0.92); C1259(1.41)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C365(1.11)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C365(0.95)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C365(0.93)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C365(1.08)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C365(0.95)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C365(0.82)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C365(0.90)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C365(0.97)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C365(0.74)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C365(0.96)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C365(0.80)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C365(0.75)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C365(0.89)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C365(0.99)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C365(0.94)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C365(0.82)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C365(0.81)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C365(0.95)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C365(0.81)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C365(0.97)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C365(0.92)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C365(0.91)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C365(0.92)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C365(0.75)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C365(0.99); C1259(0.85)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C365(0.87)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C365(0.93)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C365(0.94)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C365(0.78)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C365(0.94)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C365(1.10)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C365(1.01); C1259(1.34)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C365(0.99)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C365(0.67)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C365(0.76)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C365(0.81)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C365(1.08)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C365(1.10); C1259(0.88)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C365(1.06)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C365(0.99)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C365(0.79)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C365(0.80)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C365(1.19)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C365(0.96)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C365(1.09); C1259(1.55)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C365(0.84)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C365(1.01)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C365(0.81)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C365(0.74)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C365(0.97)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C365(1.08); C1259(0.88)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C365(0.97)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C365(1.25)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C365(0.78)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C365(1.23)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C365(0.84)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C365(1.12); C1259(1.33)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C365(0.73)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C365(0.86)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C365(1.00); C1259(1.14)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C365(0.79)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C365(0.88)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C365(1.00); C1259(0.88)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C365(0.88)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C365(0.88)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C365(0.76)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C365(0.94)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C365(0.88)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C365(0.94); C1259(1.41)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C365(1.03)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C365(0.84)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C365(0.89)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C365(1.03)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C365(0.95)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C365(1.02)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C365(0.99); C1259(0.90)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C365(1.05)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C365(0.83)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C365(0.65)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C365(1.00)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C365(0.94)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C365(1.08)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C365(1.00); C1259(1.33)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C365(0.84)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C365(0.90)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C365(1.02)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C365(0.89)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C365(1.07); C1259(1.11)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C365(1.13)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C365(1.03)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C365(0.94)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C365(1.00)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C365(0.96)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C365(0.98)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C365(1.01); C1259(1.28)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C365(1.00)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C365(0.80)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C365(1.00)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C365(0.75)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C365(0.76)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C365(1.04); C1259(1.10)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C365(1.15)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C365(0.76)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C365(0.84)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C365(0.93)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C365(1.01)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C365(0.89)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C365(0.95); C1259(1.42)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C365(0.90)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C365(1.14)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C365(0.93)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C365(0.89)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C365(0.71)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C365(0.90)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C365(0.73)  LDD1631  [3]
 LDCM0022  KB02 HCT 116 C1412(1.72)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C1412(1.27)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C1412(1.40)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biotin--protein ligase (HLCS) Biotin--protein ligase family P50747
Acetyl-CoA carboxylase 2 (ACACB) . O00763

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenine Small molecular drug DB00173
Biotin Small molecular drug DB00121
Metformin Small molecular drug D0D7LA
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-05175157 . D03KHO
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-[4-(2,4-dichlorophenoxy)Phenoxy]Propanoic Acid Small molecular drug D0K4WI
2-[4-(24-dichlorophenoxy)Phenoxy]Propanoic Acid Small molecular drug DB03781
A-80040 Small molecular drug D0IY5Y
Ac-8632 Small molecular drug D0P7HI
Cp-640186 Small molecular drug D07WIC
Soraphen A Small molecular drug D0WD1E
Haloxyfop-p . DB07870
Qlt-091382 . D08FSR
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Axokine . D01OKS

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402