Details of the Target

General Information of Target

Target ID LDTP00301
Target Name B-cell CLL/lymphoma 9 protein (BCL9)
Gene Name BCL9
Gene ID 607
Synonyms
B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; Bcl-9; Protein legless homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQ
PSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDS
DIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVF
STEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPA
PANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPP
DGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRE
RSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGP
GPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFY
EEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINM
PHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIP
DGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNR
MIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDV
NLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMG
PRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRG
LGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPA
AAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPA
MLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPS
STPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPM
GMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG
FPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGG
PDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGR
KQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPA
FLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGM
MMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
Target Bioclass
Other
Family
BCL9 family
Subcellular location
Nucleus
Function Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity.
Uniprot ID
O00512
Ensemble ID
ENST00000234739.8
HGNC ID
HGNC:1008
ChEMBL ID
CHEMBL3712821

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y480(18.98)  LDD3495  [2]
DBIA
 Probe Info  		C125(1.64)  LDD3332  [3]
AHL-Pu-1
 Probe Info  		C125(2.96)  LDD0171  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
IPM
 Probe Info  		C64(0.00); C125(0.00); C495(0.00)  LDD2156  [6]
VSF
 Probe Info  		N.A.  LDD0007  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C125(2.96)  LDD0171  [4]
 LDCM0226  AC11 HEK-293T C64(1.05)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C64(0.95)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C64(1.15); C125(0.95)  LDD1512  [8]
 LDCM0278  AC19 HEK-293T C64(1.55)  LDD1517  [8]
 LDCM0280  AC20 HEK-293T C64(1.36)  LDD1519  [8]
 LDCM0282  AC22 HEK-293T C64(0.97); C125(1.03)  LDD1521  [8]
 LDCM0284  AC24 HEK-293T C64(1.16)  LDD1523  [8]
 LDCM0287  AC27 HEK-293T C64(0.90)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C64(1.07)  LDD1527  [8]
 LDCM0290  AC3 HEK-293T C64(1.09)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C64(1.08); C125(1.01)  LDD1530  [8]
 LDCM0293  AC32 HEK-293T C64(1.29)  LDD1532  [8]
 LDCM0296  AC35 HEK-293T C64(0.82)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C64(1.20)  LDD1536  [8]
 LDCM0299  AC38 HEK-293T C64(0.93); C125(1.23)  LDD1538  [8]
 LDCM0301  AC4 HEK-293T C64(1.45)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C64(1.36)  LDD1541  [8]
 LDCM0305  AC43 HEK-293T C64(1.18)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C64(1.19)  LDD1545  [8]
 LDCM0308  AC46 HEK-293T C64(0.92); C125(1.08)  LDD1547  [8]
 LDCM0310  AC48 HEK-293T C64(1.34)  LDD1549  [8]
 LDCM0314  AC51 HEK-293T C64(1.06)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C64(1.07)  LDD1554  [8]
 LDCM0317  AC54 HEK-293T C64(1.01); C125(0.96)  LDD1556  [8]
 LDCM0319  AC56 HEK-293T C64(1.36)  LDD1558  [8]
 LDCM0322  AC59 HEK-293T C64(1.05)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C64(1.00); C125(0.99)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C64(1.32)  LDD1563  [8]
 LDCM0326  AC62 HEK-293T C64(1.00); C125(0.89)  LDD1565  [8]
 LDCM0328  AC64 HEK-293T C64(1.42)  LDD1567  [8]
 LDCM0345  AC8 HEK-293T C64(1.19)  LDD1569  [8]
 LDCM0275  AKOS034007705 HEK-293T C64(1.22)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C64(1.06)  LDD2171  [9]
 LDCM0368  CL10 HEK-293T C64(0.99); C125(0.98)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C64(0.91); C125(1.07)  LDD1573  [8]
 LDCM0372  CL103 HEK-293T C1193(1.64)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C64(1.11); C125(1.00)  LDD1577  [8]
 LDCM0376  CL107 HEK-293T C1193(1.06)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C64(1.11); C125(0.90)  LDD1581  [8]
 LDCM0381  CL111 HEK-293T C1193(0.83)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C64(1.01); C125(0.97)  LDD1586  [8]
 LDCM0385  CL115 HEK-293T C1193(1.02)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C64(1.12); C125(1.09)  LDD1590  [8]
 LDCM0389  CL119 HEK-293T C1193(1.10)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C64(1.31)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C64(1.25); C125(1.09)  LDD1595  [8]
 LDCM0394  CL123 HEK-293T C1193(1.14)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C64(1.11); C125(0.91)  LDD1599  [8]
 LDCM0398  CL127 HEK-293T C1193(1.17)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C64(1.12); C125(0.97)  LDD1603  [8]
 LDCM0402  CL15 HEK-293T C1193(1.18)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C64(0.95); C125(0.98)  LDD1607  [8]
 LDCM0406  CL19 HEK-293T C64(1.03)  LDD1610  [8]
 LDCM0408  CL20 HEK-293T C64(0.87)  LDD1612  [8]
 LDCM0410  CL22 HEK-293T C64(1.16); C125(0.91)  LDD1614  [8]
 LDCM0412  CL24 HEK-293T C64(1.28)  LDD1616  [8]
 LDCM0415  CL27 HEK-293T C1193(1.76)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C64(1.11); C125(0.98)  LDD1620  [8]
 LDCM0418  CL3 HEK-293T C1193(1.31)  LDD1622  [8]
 LDCM0420  CL31 HEK-293T C64(1.08)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C64(1.27)  LDD1625  [8]
 LDCM0423  CL34 HEK-293T C64(0.93); C125(0.91)  LDD1627  [8]
 LDCM0425  CL36 HEK-293T C64(1.16)  LDD1629  [8]
 LDCM0428  CL39 HEK-293T C1193(1.64)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C64(1.03); C125(0.93)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C64(1.21); C125(1.03)  LDD1634  [8]
 LDCM0433  CL43 HEK-293T C64(1.20)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C64(0.97)  LDD1638  [8]
 LDCM0436  CL46 HEK-293T C64(0.91); C125(0.99)  LDD1640  [8]
 LDCM0438  CL48 HEK-293T C64(1.37)  LDD1642  [8]
 LDCM0443  CL52 HEK-293T C64(0.98); C125(1.10)  LDD1646  [8]
 LDCM0446  CL55 HEK-293T C64(1.14)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C64(1.21)  LDD1650  [8]
 LDCM0449  CL58 HEK-293T C64(1.16); C125(0.97)  LDD1652  [8]
 LDCM0452  CL60 HEK-293T C64(1.15)  LDD1655  [8]
 LDCM0455  CL63 HEK-293T C1193(1.21)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C64(1.04); C125(1.03)  LDD1659  [8]
 LDCM0459  CL67 HEK-293T C64(1.17)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C64(1.28)  LDD1663  [8]
 LDCM0462  CL7 HEK-293T C64(1.03)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C64(0.93); C125(1.17)  LDD1666  [8]
 LDCM0465  CL72 HEK-293T C64(0.99)  LDD1668  [8]
 LDCM0469  CL76 HEK-293T C64(0.94); C125(1.03)  LDD1672  [8]
 LDCM0472  CL79 HEK-293T C64(1.01)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C64(0.74)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C64(0.84)  LDD1677  [8]
 LDCM0476  CL82 HEK-293T C64(0.91); C125(1.05)  LDD1679  [8]
 LDCM0478  CL84 HEK-293T C64(1.17)  LDD1681  [8]
 LDCM0481  CL87 HEK-293T C1193(1.33)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C64(1.18); C125(1.10)  LDD1685  [8]
 LDCM0486  CL91 HEK-293T C64(1.11)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C64(0.98)  LDD1690  [8]
 LDCM0489  CL94 HEK-293T C64(1.14); C125(0.91)  LDD1692  [8]
 LDCM0491  CL96 HEK-293T C64(1.44)  LDD1694  [8]
 LDCM0494  CL99 HEK-293T C1193(1.11)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C1193(1.03)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C1193(0.83)  LDD1671  [8]
 LDCM0022  KB02 HEK-293T C64(0.92); C1193(1.19)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C64(1.04); C1193(1.18)  LDD1497  [8]
 LDCM0024  KB05 MKN45 C125(1.64)  LDD3332  [3]
 LDCM0021  THZ1 HCT 116 C64(1.06)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Parafibromin (CDC73) CDC73 family Q6P1J9
Pygopus homolog 1 (PYGO1) . Q9Y3Y4
Pygopus homolog 2 (PYGO2) . Q9BRQ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.