Details of the Target

General Information of Target

Target ID LDTP00108
Target Name 12S rRNA N4-methylcytidine (m4C) methyltransferase (METTL15)
Gene Name METTL15
Gene ID 196074
Synonyms
METT5D1; 12S rRNA N4-methylcytidine; m4C) methyltransferase; 12S rRNA m4C methyltransferase; EC 2.1.1.-; Methyltransferase 5 domain-containing protein 1; Methyltransferase-like protein 15
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRS
QDRDFETMAKLHIPVMVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDR
DPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTP
ERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRTYGEEKHAKKIASAIV
QARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRIFVNNELNELY
TGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSVRQQVMKTSQLGSDH
ENTEEVSMRRAPLMWELIHKKVLSPQDQDVQDNPRGRSAKLRAAIKL
Target Bioclass
Enzyme
Family
Methyltransferase superfamily, RsmH family
Subcellular location
Mitochondrion matrix
Function
N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits.
Uniprot ID
A6NJ78
Ensemble ID
ENST00000303459.10
HGNC ID
HGNC:26606

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.D119V .
SISO Substitution: p.M168_D169delinsIY .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K230(1.05)  LDD0277  [1]
IA-alkyne
 Probe Info  		C172(3.31)  LDD2157  [2]
DBIA
 Probe Info  		C172(0.91)  LDD1187  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
AOyne
 Probe Info  		9.50  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C172(1.09); C83(0.99)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C172(1.10); C83(0.96)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C172(0.97); C83(0.94)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C172(1.01); C83(1.03)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C172(1.13); C83(0.95)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C172(0.95); C83(1.02)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C172(1.05); C83(0.99)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C172(0.97); C83(1.03)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C172(0.88); C83(0.92)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C172(0.98); C83(1.11)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C172(0.98); C83(0.91)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C172(0.85); C83(1.00)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C172(1.04); C83(1.00)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C172(1.01); C83(1.10)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C172(0.92); C83(1.12)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C172(0.97); C83(1.09)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C172(1.03); C83(0.94)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C172(1.02); C83(0.94)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C172(0.93); C83(1.05)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C172(1.02); C83(1.05)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C172(0.97); C83(0.94)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C172(1.00); C83(0.96)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C172(0.89); C83(0.99)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C172(1.10); C83(1.05)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C172(1.09); C83(1.00)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C172(0.95); C83(0.99)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C172(1.01); C83(0.90)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C172(1.00); C83(1.12)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C172(1.09); C83(0.98)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C172(0.99); C83(0.96)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C172(0.96); C83(0.97)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C172(0.98); C83(0.98)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C172(1.06); C83(0.97)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C172(1.11); C83(1.08)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C172(1.04); C83(1.00)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C172(1.02); C83(0.89)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C172(0.95); C83(1.06)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C172(1.05); C83(0.96)  LDD1546  [6]
 LDCM0308  AC46 PaTu 8988t C172(0.91)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C172(1.00)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C172(1.08)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C172(1.20)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C172(1.05); C83(0.90)  LDD1551  [6]
 LDCM0313  AC50 PaTu 8988t C172(1.24)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C172(0.18)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C172(0.78)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C172(1.60)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C172(1.09)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C172(1.26)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C172(0.96)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C172(1.04); C83(1.05)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C172(0.95); C83(1.08)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C172(1.07); C83(0.92)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C172(1.01); C83(0.98)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C172(1.02); C83(0.95)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C172(0.85); C83(1.00)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C172(0.99); C83(0.96)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C172(0.94); C83(0.94)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C172(1.09); C83(1.15)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C172(1.01); C83(1.02)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C172(1.16); C83(1.05)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C172(0.83); C83(1.00)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C172(1.04); C83(1.02)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C172(1.24); C83(1.09)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C172(0.97); C83(1.01)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C172(0.92); C83(0.97)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C172(0.87); C83(0.91)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C172(0.95); C83(0.94)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C172(0.96); C83(1.00)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C172(1.07); C83(0.89)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C172(0.83); C83(0.91)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C172(0.95); C83(0.92)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C172(0.91); C83(0.93)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C172(1.15); C83(0.96)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C172(0.86); C83(0.93)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C172(1.07); C83(0.91)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C172(1.12); C83(1.04)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C172(0.88); C83(0.90)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C172(1.00); C83(0.90)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C172(0.82); C83(0.85)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C172(0.98); C83(1.06)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C172(0.97); C83(0.99)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C172(1.03); C83(0.85)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C172(0.94); C83(1.00)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C172(0.95); C83(0.99)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C172(1.04); C83(1.08)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C172(0.96); C83(1.01)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C172(1.07); C83(0.98)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C172(1.06); C83(0.99)  LDD1595  [6]
 LDCM0392  CL121 PaTu 8988t C172(1.18)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C172(0.70)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C172(1.21)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C172(1.01)  LDD1274  [3]
 LDCM0396  CL125 HEK-293T C172(1.09); C83(0.95)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C172(0.91); C83(0.96)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C172(1.04); C83(0.88)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C172(0.96); C83(0.94)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C172(0.94); C83(0.93)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C172(1.11); C83(0.99)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C172(1.06); C83(0.99)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C172(0.85); C83(0.98)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C172(1.01); C83(1.02)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C172(1.05); C83(1.08)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C172(1.05); C83(0.88)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C172(0.94); C83(1.05)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C172(0.97); C83(0.98)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C172(0.10); C83(0.88)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C172(1.14); C83(0.91)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C172(1.09); C83(1.06)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C172(1.02); C83(1.05)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C172(1.01); C83(0.99)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C172(1.05); C83(1.02)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C172(1.11); C83(0.93)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C172(1.07); C83(0.96)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C172(1.02); C83(0.96)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C172(1.16); C83(0.92)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C172(1.10); C83(1.08)  LDD1623  [6]
 LDCM0420  CL31 PaTu 8988t C172(1.07)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C172(0.79)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C172(1.04)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C172(1.31)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C172(1.25)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C172(0.40)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C172(1.04)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C172(1.14)  LDD1307  [3]
 LDCM0429  CL4 HEK-293T C172(1.01); C83(0.98)  LDD1633  [6]
 LDCM0430  CL40 PaTu 8988t C172(0.74)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C172(0.78)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C172(1.09)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C172(1.12)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C172(1.12)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C172(1.19)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C172(1.54)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C172(1.58)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C172(1.23)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C172(1.39)  LDD1318  [3]
 LDCM0440  CL5 HEK-293T C172(1.12); C83(1.01)  LDD1644  [6]
 LDCM0441  CL50 PaTu 8988t C172(1.43)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C172(1.55)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C172(1.49)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C172(1.75)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C172(1.97)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C172(1.50)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C172(1.37)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C172(1.50)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C172(1.41)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C172(1.62)  LDD1329  [3]
 LDCM0451  CL6 HEK-293T C172(1.11); C83(0.97)  LDD1654  [6]
 LDCM0452  CL60 PaTu 8988t C172(1.93)  LDD1331  [3]
 LDCM0453  CL61 HEK-293T C172(1.11); C83(1.01)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C172(0.93); C83(0.90)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C172(1.06); C83(0.96)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C172(0.84); C83(0.93)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C172(1.03); C83(0.98)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C172(1.34); C83(0.95)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C172(0.96); C83(0.91)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C172(0.88); C83(0.96)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C172(1.09); C83(0.94)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C172(1.04); C83(0.96)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C172(1.15); C83(0.98)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C172(0.86); C83(0.94)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C172(1.13); C83(1.00)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C172(0.90); C83(0.91)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C172(0.97); C83(0.96)  LDD1670  [6]
 LDCM0469  CL76 PaTu 8988t C172(1.43)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C172(1.01)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C172(1.40)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C172(1.33)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C172(1.13); C83(0.87)  LDD1676  [6]
 LDCM0474  CL80 PaTu 8988t C172(1.37)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C172(1.46)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C172(2.17)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C172(1.29)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C172(1.02)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C172(1.32)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C172(1.49)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C172(1.26)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C172(1.75)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C172(1.46)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C172(1.06); C83(0.96)  LDD1687  [6]
 LDCM0485  CL90 PaTu 8988t C172(1.45)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C172(0.98); C83(0.87)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C172(0.91); C83(0.96)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C172(1.05); C83(0.90)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C172(0.98); C83(0.97)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C172(0.75); C83(0.92)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C172(0.98); C83(0.93)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C172(0.79); C83(1.01)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C172(0.92); C83(0.99)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C172(0.98); C83(0.87)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C172(1.06); C83(1.00)  LDD1698  [6]
 LDCM0625  F8 Ramos C83(1.25)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C83(1.98)  LDD2190  [7]
 LDCM0576  Fragment14 Ramos C83(1.20)  LDD2193  [7]
 LDCM0586  Fragment28 Ramos C83(0.25)  LDD2198  [7]
 LDCM0468  Fragment33 HEK-293T C172(1.02); C83(0.90)  LDD1671  [6]
 LDCM0566  Fragment4 Ramos C83(0.75)  LDD2184  [7]
 LDCM0427  Fragment51 PaTu 8988t C172(1.33)  LDD1306  [3]
 LDCM0569  Fragment7 Ramos C83(1.60)  LDD2186  [7]
 LDCM0022  KB02 HEK-293T C83(1.00); C172(0.84)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C83(1.03); C172(1.12)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C83(0.99); C172(0.95)  LDD1502  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Serine--tRNA ligase, cytoplasmic (SARS1) Class-II aminoacyl-tRNA synthetase family P49591
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Caspase-6 (CASP6) Peptidase C14A family P55212
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
E3 ubiquitin-protein ligase FANCL (FANCL) . Q9NW38
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEC (CIDEC) CIDE family Q96AQ7
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) . O60336
Peflin (PEF1) . Q9UBV8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578