Details of the Target

General Information of Target

Target ID LDTP19956
Target Name Uncharacterized protein C1orf21 (C1orf21)
Gene Name C1orf21
Gene ID 81563
Synonyms
Uncharacterized protein C1orf21; Cell proliferation-inducing gene 13 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGAPLLSPGWGAGAAGRRWWMLLAPLLPALLLVRPAGALVEGLYCGTRDCYEVLGVSRSA
GKAEIARAYRQLARRYHPDRYRPQPGDEGPGRTPQSAEEAFLLVATAYETLKDEETRKDY
DYMLDHPEEYYSHYYHYYSRRLAPKVDVRVVILVSVCAISVFQFFSWWNSYNKAISYLAT
VPKYRIQATEIAKQQGLLKKAKEKGKNKKSKEEIRDEEENIIKNIIKSKIDIKGGYQKPQ
ICDLLLFQIILAPFHLCSYIVWYCRWIYNFNIKGKEYGEEERLYIIRKSMKMSKSQFDSL
EDHQKETFLKRELWIKENYEVYKQEQEEELKKKLANDPRWKRYRRWMKNEGPGRLTFVDD
Target Bioclass
Other
Uniprot ID
Q9H246
Ensemble ID
ENST00000235307.7
HGNC ID
HGNC:15494

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C3(1.03)  LDD1492  [1]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C3(0.72)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C3(0.67)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C3(0.73)  LDD1513  [1]
 LDCM0280  AC20 HEK-293T C3(0.70)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C3(0.72)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C3(0.80)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C3(0.77)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C3(0.79)  LDD1523  [1]
 LDCM0288  AC28 HEK-293T C3(0.71)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C3(0.70)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C3(0.76)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C3(0.84)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C3(0.85)  LDD1532  [1]
 LDCM0297  AC36 HEK-293T C3(0.84)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C3(0.76)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C3(0.68)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C3(0.75)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C3(0.86)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C3(0.94)  LDD1541  [1]
 LDCM0306  AC44 HEK-293T C3(0.62)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C3(0.73)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C3(0.70)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C3(0.75)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C3(0.71)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C3(0.91)  LDD1551  [1]
 LDCM0315  AC52 HEK-293T C3(0.71)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C3(0.70)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C3(0.58)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C3(0.66)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C3(0.74)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C3(0.89)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C3(0.98)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C3(0.93)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C3(0.81)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C3(1.00)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C3(0.83)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C3(0.92)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C3(0.97)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C3(0.73)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C3(0.69)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C3(1.35)  LDD1572  [1]
 LDCM0372  CL103 HEK-293T C3(0.70)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C3(0.67)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C3(1.22)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C3(0.82)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C3(0.81)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C3(0.72)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C3(1.52)  LDD1594  [1]
 LDCM0394  CL123 HEK-293T C3(0.60)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C3(0.96)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C3(0.72)  LDD1606  [1]
 LDCM0408  CL20 HEK-293T C3(0.91)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C3(0.75)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C3(0.78)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C3(0.93)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C3(1.04)  LDD1616  [1]
 LDCM0415  CL27 HEK-293T C3(0.75)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C3(0.92)  LDD1622  [1]
 LDCM0421  CL32 HEK-293T C3(0.61)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C3(0.61)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C3(0.70)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C3(0.83)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C3(0.91)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C3(0.79)  LDD1632  [1]
 LDCM0434  CL44 HEK-293T C3(0.88)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C3(0.71)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C3(0.86)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C3(1.00)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C3(1.04)  LDD1642  [1]
 LDCM0447  CL56 HEK-293T C3(0.84)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C3(0.77)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C3(0.59)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C3(0.78)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C3(1.05)  LDD1655  [1]
 LDCM0455  CL63 HEK-293T C3(0.82)  LDD1658  [1]
 LDCM0460  CL68 HEK-293T C3(0.80)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C3(0.65)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C3(0.85)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C3(0.72)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C3(1.02)  LDD1668  [1]
 LDCM0473  CL8 HEK-293T C3(1.21)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C3(0.70)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C3(0.58)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C3(0.75)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C3(0.81)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C3(0.97)  LDD1681  [1]
 LDCM0481  CL87 HEK-293T C3(1.05)  LDD1684  [1]
 LDCM0484  CL9 HEK-293T C3(1.00)  LDD1687  [1]
 LDCM0487  CL92 HEK-293T C3(0.91)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C3(0.76)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C3(0.90)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C3(1.03)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C3(1.00)  LDD1694  [1]
 LDCM0494  CL99 HEK-293T C3(1.11)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C3(0.79)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C3(0.72)  LDD1671  [1]
 LDCM0022  KB02 HEK-293T C3(1.03)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C3(0.90)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C3(1.01)  LDD1502  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) Phosphatase 2A regulatory subunit B56 family Q15172
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-regulated autophagy modulator protein 1 (DRAM1) DRAM/TMEM150 family Q8N682

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004