Details of the Target

General Information of Target

Target ID LDTP19840
Target Name Tetratricopeptide repeat protein 9A (TTC9)
Gene Name TTC9
Gene ID 23508
Synonyms
KIAA0227; TTC9A; Tetratricopeptide repeat protein 9A; TPR repeat protein 9A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAANATSGRPPSIALRQPEATGWRRGIPAKVATKGTQAEREGDVRSGGRARGRCVRLAKR
CSPSSLGLRRRRRRTGGRQGDPQIFLGSDFRLLTPANSNPVLENPARTGSRIVIGISRER
NLPFCGRSNLPDVSSL
Target Bioclass
Other
Family
TTC9 family
Uniprot ID
Q92623
Ensemble ID
ENST00000256367.3
HGNC ID
HGNC:20267

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C30(2.82)  LDD3337  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C30(1.05)  LDD1508  [4]
 LDCM0259  AC14 HEK-293T C30(0.98)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C30(1.01)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C30(1.12)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C30(1.10)  LDD1518  [4]
 LDCM0282  AC22 HEK-293T C30(0.94)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C30(0.95)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C30(0.93)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C30(0.97)  LDD1525  [4]
 LDCM0291  AC30 HEK-293T C30(0.94)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C30(1.01)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C30(0.98)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C30(1.15)  LDD1534  [4]
 LDCM0299  AC38 HEK-293T C30(0.93)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C30(1.01)  LDD1539  [4]
 LDCM0302  AC40 HEK-293T C30(1.03)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C30(1.10)  LDD1543  [4]
 LDCM0308  AC46 HEK-293T C30(1.11)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C30(0.98)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C30(1.10)  LDD1549  [4]
 LDCM0313  AC50 HEK-293T C30(1.01)  LDD1552  [4]
 LDCM0317  AC54 HEK-293T C30(0.96)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C30(0.97)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C30(1.10)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C30(1.11)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C30(0.99)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C30(1.10)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C30(0.95)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C30(1.14)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C30(0.98)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C30(1.40)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C30(1.07)  LDD1514  [4]
 LDCM0368  CL10 HEK-293T C30(0.95)  LDD1572  [4]
 LDCM0371  CL102 HEK-293T C30(1.07)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C30(0.99)  LDD1579  [4]
 LDCM0379  CL11 HEK-293T C30(1.05)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C30(1.09)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C30(0.96)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C30(1.12)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C30(0.88)  LDD1594  [4]
 LDCM0393  CL122 HEK-293T C30(1.04)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C30(1.05)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C30(1.05)  LDD1605  [4]
 LDCM0405  CL18 HEK-293T C30(0.91)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C30(1.21)  LDD1611  [4]
 LDCM0410  CL22 HEK-293T C30(1.25)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C30(1.00)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C30(0.82)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C30(1.15)  LDD1618  [4]
 LDCM0419  CL30 HEK-293T C30(1.00)  LDD1623  [4]
 LDCM0423  CL34 HEK-293T C30(1.02)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C30(1.10)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C30(0.83)  LDD1629  [4]
 LDCM0432  CL42 HEK-293T C30(0.84)  LDD1636  [4]
 LDCM0436  CL46 HEK-293T C30(1.07)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C30(1.15)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C30(0.73)  LDD1642  [4]
 LDCM0441  CL50 HEK-293T C30(1.20)  LDD1645  [4]
 LDCM0445  CL54 HEK-293T C30(1.04)  LDD1648  [4]
 LDCM0449  CL58 HEK-293T C30(1.09)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C30(1.14)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C30(0.92)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C30(0.75)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C30(1.13)  LDD1657  [4]
 LDCM0458  CL66 HEK-293T C30(0.96)  LDD1661  [4]
 LDCM0463  CL70 HEK-293T C30(1.02)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C30(1.08)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C30(0.87)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C30(1.18)  LDD1670  [4]
 LDCM0471  CL78 HEK-293T C30(1.16)  LDD1674  [4]
 LDCM0476  CL82 HEK-293T C30(1.08)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C30(1.02)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C30(0.94)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C30(1.07)  LDD1683  [4]
 LDCM0485  CL90 HEK-293T C30(1.08)  LDD1688  [4]
 LDCM0489  CL94 HEK-293T C30(1.11)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C30(1.14)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C30(0.93)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C30(1.16)  LDD1696  [4]
 LDCM0625  F8 Ramos C30(1.59)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C30(1.19)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C30(6.29)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C30(0.67)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C30(1.82)  LDD2192  [5]
 LDCM0576  Fragment14 Ramos C30(0.77)  LDD2193  [5]
 LDCM0579  Fragment20 Ramos C30(0.57)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C30(0.95)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C30(1.26)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C30(0.86)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C30(0.74)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C30(0.98)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C30(0.83)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C30(1.22)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C30(1.08)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C30(0.85)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C30(0.82)  LDD2184  [5]
 LDCM0427  Fragment51 HEK-293T C30(1.08)  LDD1631  [4]
 LDCM0610  Fragment52 Ramos C30(1.49)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C30(1.42)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C30(0.87)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C30(0.80)  LDD2188  [5]
 LDCM0022  KB02 HEK-293T C30(0.89)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C30(1.09)  LDD1497  [4]
 LDCM0024  KB05 MSTO-211H C30(2.82)  LDD3337  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578