Details of the Target

General Information of Target

Target ID LDTP19312
Target Name Tigger transposable element-derived protein 2 (TIGD2)
Gene Name TIGD2
Gene ID 166815
Synonyms
Tigger transposable element-derived protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRELRGCPGGDVETAQRLSRRRRGKSSEAVPEKTWRAQRMSQTRESSEAVPEKTWREFR
GCPGEDVERAQKLRDCPGEDMETAQTLSARRRAESSEAVPEKTWRELKGCPQEDVERVQR
LSLLLHLAVFLWIIIAINFSNSGVKSQSSTYLPSGKILK
Target Bioclass
Other
Family
Tigger transposable element derived protein family
Subcellular location
Nucleus
Uniprot ID
Q4W5G0
Ensemble ID
ENST00000603357.3
HGNC ID
HGNC:18333

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C202(1.19)  LDD0532  [1]
Compound 10
 Probe Info  		N.A.  LDD2216  [2]
IPM
 Probe Info  		C102(0.00); C202(0.00)  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C202(1.19)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C202(1.31)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C202(1.03)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C202(1.16)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C202(1.28)  LDD0587  [1]
 LDCM0283  AC23 HEK-293T C102(1.22)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C102(1.06)  LDD1523  [5]
 LDCM0292  AC31 HEK-293T C102(1.46)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C102(1.08)  LDD1532  [5]
 LDCM0300  AC39 HEK-293T C102(1.15)  LDD1539  [5]
 LDCM0302  AC40 HEK-293T C102(1.03)  LDD1541  [5]
 LDCM0309  AC47 HEK-293T C102(1.04)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C102(1.53)  LDD1549  [5]
 LDCM0318  AC55 HEK-293T C102(1.23)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C102(1.04)  LDD1558  [5]
 LDCM0323  AC6 HCT 116 C202(1.21)  LDD0640  [1]
 LDCM0327  AC63 HEK-293T C102(1.08)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C102(0.93)  LDD1567  [5]
 LDCM0332  AC68 HCT 116 C202(0.88)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C202(0.88)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C202(1.16)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C202(1.03)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C202(0.88)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C202(1.06)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C202(1.21)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C202(1.03)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C202(1.10)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C202(1.09)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C202(0.91)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C202(0.95)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C202(1.03)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C202(1.09)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C202(1.23)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C202(0.96)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C202(1.04)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C202(1.01)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C202(1.23)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C202(1.28)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C202(1.16)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C202(1.20)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C202(1.09)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C202(1.38)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C202(1.11)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C202(1.47)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C202(1.47)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C202(1.18)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C202(1.37)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C202(1.79)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C202(1.69)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C202(1.36)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C202(1.07)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C202(1.11)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C202(1.77)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C202(1.36)  LDD2171  [1]
 LDCM0370  CL101 HCT 116 C202(1.55)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C202(1.01)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C202(1.18)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C202(1.17)  LDD0690  [1]
 LDCM0379  CL11 HEK-293T C102(0.99)  LDD1583  [5]
 LDCM0390  CL12 HEK-293T C102(1.09)  LDD1594  [5]
 LDCM0403  CL16 HCT 116 C202(1.36)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C202(0.94)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C202(0.97)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C202(1.10)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C202(1.16)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C202(1.50)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C202(1.10)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C202(1.05)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C202(1.32)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C202(1.38)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C202(1.35)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C202(1.13)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C202(1.40)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C202(1.31)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C202(1.13)  LDD0736  [1]
 LDCM0424  CL35 HEK-293T C102(1.31)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C102(1.17)  LDD1629  [5]
 LDCM0436  CL46 HCT 116 C202(1.02)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C202(0.96)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C202(0.99)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C202(0.96)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C202(0.94)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C202(0.99)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C202(1.09)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C202(0.99)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C202(0.98)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C202(0.86)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C202(0.88)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C202(0.92)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C202(0.90)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C202(0.91)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C202(0.94)  LDD0769  [1]
 LDCM0464  CL71 HEK-293T C102(1.29)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C102(1.09)  LDD1668  [5]
 LDCM0477  CL83 HEK-293T C102(1.59)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C102(1.27)  LDD1681  [5]
 LDCM0490  CL95 HEK-293T C102(1.46)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C102(1.02)  LDD1694  [5]
 LDCM0022  KB02 A2780 C226(2.04)  LDD2254  [6]
 LDCM0023  KB03 A2780 C226(4.31)  LDD2671  [6]
 LDCM0024  KB05 NCI-H1650 C226(4.24)  LDD3345  [6]
 LDCM0021  THZ1 HCT 116 C202(1.36)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840