Details of the Target

General Information of Target

Target ID LDTP18514
Target Name Transmembrane protein 181 (TMEM181)
Gene Name TMEM181
Gene ID 57583
Synonyms
GPR178; KIAA1423; Transmembrane protein 181
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDQFGDILEGEVDHSFFDSDFEEGKKCETNSVFDKQNDDPKERIDKDTKNVNSNTGMQTT
ENYLTEKGNERNVKFPPEHPVENDVTQTVSSFSLPASSRSKKLCDVTTGLKIHVSIPNRI
PKIVKEGEDDYYTDGEESSDDGKKYHVKSKSAKPSTNVKKSIRKKYCKVSSSSSSSLSSS
SSGSGTDCLDAGSDSHLSDSSPSSKSSKKHVSGITLLSPKHKYKSGIKSTETQPSSTTPK
CGHYPEESEDTVTDVSPLSTPDISPLQSFELGIANDQKVKIKKQENVSQEIYEDVEDLKN
NSKYLKAAKKGKEKHEPDVSSKSSSVLDSSLDHRHKQKVLHDTMDLNHLLKAFLQLDKKG
PQKHHFDQPSVAPGKNYSFTREEVRQIDRENQRLLKELSRQAEKPGSKSTIPRSADHPPK
LYHSALNRQKEQQRIERENLALLKRLEAVKPTVGMKRSEQLMDYHRNMGYLNSSPLSRRA
RSTLGQYSPLRASRTSSATSGLSCRSERSAVDPSSGHPRRRPKPPNVRTAWL
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Uniprot ID
Q9P2C4
Ensemble ID
ENST00000367090.4
HGNC ID
HGNC:20958

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C262(2.45)  LDD3352  [1]
BTD
 Probe Info  		C262(2.01)  LDD2100  [2]
IPM
 Probe Info  		C262(8.44)  LDD1701  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C215(1.25)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C215(1.09)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C215(0.92); C262(1.01)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C215(1.09); C262(0.95)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C215(1.10); C262(0.94)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C215(0.90)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C215(1.07)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C215(0.84); C262(1.11)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C215(1.11)  LDD1518  [3]
 LDCM0282  AC22 HEK-293T C215(1.10); C262(0.98)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C215(0.94); C262(1.02)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C215(1.17)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C215(0.81)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C215(1.08)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C215(0.85); C262(0.98)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C215(0.89); C262(0.97)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C215(0.91); C262(0.95)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C215(1.22); C262(0.99)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C215(1.15)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C215(0.96)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C215(1.05)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C215(0.88); C262(0.96)  LDD1535  [3]
 LDCM0299  AC38 HEK-293T C215(1.16); C262(0.88)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C215(1.07); C262(0.93)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C215(1.06)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C215(1.15)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C215(1.01)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C215(1.02); C262(1.02)  LDD1544  [3]
 LDCM0308  AC46 HEK-293T C215(1.00); C262(0.88)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C215(0.92); C262(1.00)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C215(1.15)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C215(0.97)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C215(1.06)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C215(0.93); C262(1.04)  LDD1553  [3]
 LDCM0317  AC54 HEK-293T C215(0.93); C262(0.96)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C215(1.11); C262(0.98)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C215(1.18)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C215(0.87)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C215(0.97)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C215(1.05); C262(0.96)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C215(1.04); C262(0.94)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C215(1.35); C262(0.88)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C215(0.95); C262(0.92)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C215(1.05)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C215(1.33); C262(0.99)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C215(1.14)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C215(1.07)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C215(1.15)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C215(1.21)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C215(1.36); C262(1.20)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C215(1.01)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C215(0.86)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C215(0.87)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C215(0.93)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C215(0.85)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C215(1.03)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C215(0.97)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C215(0.97)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C215(0.86)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C215(0.85)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C215(1.21); C262(1.05)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C215(0.97)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C215(0.94)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C215(0.95)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C215(1.05)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C215(0.85)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C215(0.88)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C215(0.85)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C215(1.02)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C215(0.92)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C215(0.96)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C215(1.32)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C215(0.99)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C215(1.01)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C215(1.08)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C215(0.94)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C215(1.01)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C215(1.14)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C215(0.88)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C215(1.00)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C215(1.14)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C215(1.01)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C215(0.97)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C215(0.93)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C215(0.95)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C215(0.86)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C215(1.01)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C215(1.18); C262(1.04)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C215(0.96)  LDD1611  [3]
 LDCM0410  CL22 HEK-293T C215(1.44); C262(1.09)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C215(1.11); C262(1.08)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C215(1.43)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C215(0.99)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C215(0.91)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C215(0.97)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C215(1.05)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C215(0.89)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C215(1.08)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C215(0.99)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C215(1.00); C262(1.10)  LDD1624  [3]
 LDCM0423  CL34 HEK-293T C215(1.32); C262(1.24)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C215(1.17); C262(1.19)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C215(1.29)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C215(1.08)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C215(0.99)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C215(0.90)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C215(1.02)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C215(0.84)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C215(0.91)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C215(0.94); C262(1.09)  LDD1637  [3]
 LDCM0436  CL46 HEK-293T C215(1.38); C262(1.17)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C215(1.43); C262(1.15)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C215(1.30)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C215(1.24)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C215(0.94)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C215(0.99)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C215(0.86)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C215(0.81)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C215(1.02)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C215(0.93); C262(1.05)  LDD1649  [3]
 LDCM0449  CL58 HEK-293T C215(1.40); C262(1.07)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C215(1.19); C262(1.11)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C215(1.09)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C215(1.18)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C215(1.15)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C215(1.07)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C215(0.94)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C215(0.96)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C215(1.03)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C215(1.00)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C215(1.02); C262(1.05)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C215(1.04); C262(0.97)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C215(1.36); C262(1.04)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C215(1.33); C262(1.03)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C215(1.25)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C215(1.29)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C215(1.02)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C215(0.96)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C215(0.75)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C215(1.16)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C215(1.03); C262(1.05)  LDD1675  [3]
 LDCM0476  CL82 HEK-293T C215(1.08); C262(0.99)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C215(1.27); C262(1.03)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C215(1.14)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C215(1.13)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C215(1.03)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C215(1.06)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C215(0.93)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C215(0.83)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C215(1.12)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C215(0.97); C262(1.02)  LDD1689  [3]
 LDCM0489  CL94 HEK-293T C215(1.00); C262(0.94)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C215(1.15); C262(1.09)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C215(1.42)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C215(1.12)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C215(0.89)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C215(1.05)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C215(0.98)  LDD1698  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C262(3.07)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C215(0.99)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C215(0.91)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C262(0.96); C215(1.11)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C262(1.03); C215(1.09)  LDD1497  [3]
 LDCM0024  KB05 NCI-H1975 C262(2.45)  LDD3352  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C262(2.01)  LDD2100  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C262(2.25)  LDD2116  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402