Details of the Target

General Information of Target

Target ID LDTP18304
Target Name Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 (CHCHD5)
Gene Name CHCHD5
Gene ID 84269
Synonyms
C2orf9; Coiled-coil-helix-coiled-coil-helix domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPPPPRQPPPQARAARGAVRLQRPFLRSPLGVLRLLQLLAGAAFWITIATSKYQGPVHF
ALFVSVLFWLLTLGLYFLTLLGKHELVPVLGSRWLMVNVAHDVLAAALYGAATGIMSDQM
QRHSYCNLKDYPLPCAYHAFLAAAVCGGVCHGLYLLSALYGCGRRCQGKQEVA
Target Bioclass
Other
Subcellular location
Mitochondrion intermembrane space
Uniprot ID
Q9BSY4
Ensemble ID
ENST00000324913.10
HGNC ID
HGNC:17840

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH2172 SNV: p.R70P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]
DBIA
 Probe Info  		C58(2.55); C68(2.55)  LDD0080  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
IA-alkyne
 Probe Info  		C206(0.00); C223(0.00)  LDD0161  [4]
NAIA_5
 Probe Info  		C22(0.00); C89(0.00); C44(0.00); C79(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HEK-293T C58(0.64); C68(0.64)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C58(0.81); C68(0.81)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C58(0.85); C68(0.85)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C58(0.82); C68(0.82)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C58(0.96); C68(0.96)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C58(1.07); C68(1.07)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C58(1.37); C68(1.37)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C58(1.35); C68(1.35)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C58(0.69); C68(0.69)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C58(0.70); C68(0.70)  LDD0823  [2]
 LDCM0227  AC110 HEK-293T C58(1.04); C68(1.04)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C58(0.97); C68(0.97)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C58(0.75); C68(0.75)  LDD0827  [2]
 LDCM0246  AC128 HEK-293T C58(0.94); C68(0.94)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C58(1.22); C68(1.22)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C58(1.60); C68(1.60)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C58(1.22); C68(1.22)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C58(1.26); C68(1.26)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C58(1.04); C68(1.04)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C58(0.85); C68(0.85)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C58(0.91); C68(0.91)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C58(0.97); C68(0.97)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C58(1.11); C68(1.11)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C58(0.87); C68(0.87)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C58(0.90); C68(0.90)  LDD0856  [2]
 LDCM0260  AC140 HEK-293T C58(0.90); C68(0.90)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C58(0.86); C68(0.86)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C58(1.03); C68(1.03)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C58(0.70); C68(0.70)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C58(0.81); C68(0.81)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C58(0.81); C68(0.81)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C58(0.88); C68(0.88)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C58(0.76); C68(0.76)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C58(0.81); C68(0.81)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C58(0.80); C68(0.80)  LDD0867  [2]
 LDCM0271  AC150 HEK-293T C58(0.66); C68(0.66)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C58(0.80); C68(0.80)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C58(0.83); C68(0.83)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C58(0.93); C68(0.93)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C58(0.95); C68(0.95)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C58(0.82); C68(0.82)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C58(0.89); C68(0.89)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C58(0.71); C68(0.71)  LDD2165  [2]
 LDCM0365  AC98 HEK-293T C58(0.99); C68(0.99)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C58(1.09); C68(1.09)  LDD0964  [2]
 LDCM0020  ARS-1620 HCC44 C79(0.95)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C58(1.11); C68(1.11)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C58(1.01); C68(1.01)  LDD0966  [2]
 LDCM0379  CL11 HEK-293T C58(0.88); C68(0.88)  LDD0977  [2]
 LDCM0390  CL12 HEK-293T C58(0.78); C68(0.78)  LDD0988  [2]
 LDCM0400  CL13 HEK-293T C58(1.28); C68(1.28)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C58(1.39); C68(1.39)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C58(1.55); C68(1.55)  LDD1000  [2]
 LDCM0407  CL2 HEK-293T C58(1.20); C68(1.20)  LDD1005  [2]
 LDCM0418  CL3 HEK-293T C58(0.84); C68(0.84)  LDD1016  [2]
 LDCM0429  CL4 HEK-293T C58(0.76); C68(0.76)  LDD1027  [2]
 LDCM0436  CL46 HEK-293T C58(1.25); C68(1.25)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C58(1.28); C68(1.28)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C58(1.05); C68(1.05)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C58(1.78); C68(1.78)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C58(0.72); C68(0.72)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C58(1.59); C68(1.59)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C58(1.28); C68(1.28)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C58(1.27); C68(1.27)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C58(1.36); C68(1.36)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C58(1.40); C68(1.40)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C58(0.95); C68(0.95)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C58(1.82); C68(1.82)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C58(1.67); C68(1.67)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C58(0.99); C68(0.99)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C58(1.22); C68(1.22)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C58(0.75); C68(0.75)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C58(1.19); C68(1.19)  LDD1050  [2]
 LDCM0462  CL7 HEK-293T C58(0.90); C68(0.90)  LDD1060  [2]
 LDCM0022  KB02 HCT 116 C58(2.55); C68(2.55)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C58(3.85); C68(3.85)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C58(4.45); C68(4.45)  LDD0082  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]
 LDCM0021  THZ1 HCT 116 C79(0.95)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264