Details of the Target

General Information of Target

Target ID LDTP18085
Target Name Transmembrane protein 255B (TMEM255B)
Gene Name TMEM255B
Gene ID 348013
Synonyms
FAM70B; Transmembrane protein 255B; Protein FAM70B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCS
QNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYRFPPSSPLKPYPKKPP
NQKDVIKFPEWNDLPPGTSQENIPVRPVVMNSEMWYKRHSIAIGEVPACRLVHRRQLTEA
NVEEIWKSMTLSYLQKILGLDSLEEVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELP
HWVLSAMKCLANWPNCSDLKQPMYLGFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLG
LLQKEKVAVEAFQICCLLLPPENRRKLQLLMRMMARICLNKEMPPLCDGFGTRTLMVQTF
SRCILCSKDEVDLDELLAARLVTFLMDNYQEILKVPLALQTSIEERVAHLRRVQIKYPGA
DMDITLSAPSFCRQISPEEFEYQRSYGSQEPLAALLEEVITDAKLSNKEKKKKLKQFQKS
YPEVYQERFPTPESAALLFPEKPKPKPQLLMWALKKPFQPFQRTRSFRM
Target Bioclass
Transporter and channel
Family
TMEM255 family
Subcellular location
Membrane
Uniprot ID
Q8WV15
Ensemble ID
ENST00000375353.5
HGNC ID
HGNC:28297

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C263(1.23); C273(1.23)  LDD0531  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C263(1.23); C273(1.23)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C263(0.78); C273(0.78)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C263(1.07); C273(1.07)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C263(1.11); C273(1.11)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C263(1.06); C273(1.06)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C263(1.22); C273(1.22)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C263(1.14); C273(1.14)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C263(0.83); C273(0.83)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C263(0.86); C273(0.56)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C263(0.88); C273(1.94)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C263(1.03); C273(1.28)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C263(1.15); C273(0.76)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C263(1.12); C273(1.10)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C263(1.37); C273(0.55)  LDD0546  [1]
 LDCM0276  AC17 HCT 116 C263(1.23); C273(1.23)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C263(1.70); C273(1.70)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C263(1.16); C273(1.16)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C263(1.45); C273(1.45)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C263(1.23); C273(1.23)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C263(1.10); C273(1.10)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C263(0.90); C273(0.90)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C263(1.16); C273(1.16)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C263(1.01); C273(1.01)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C263(1.04); C273(1.04)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C263(1.50); C273(1.50)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C263(1.19); C273(1.19)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C263(1.24); C273(1.24)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C263(1.36); C273(1.36)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C263(1.45); C273(1.45)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C263(1.25); C273(1.25)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C263(1.52); C273(1.52)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C263(1.19); C273(1.19)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C263(1.53); C273(1.53)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C263(1.47); C273(1.47)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C263(0.73); C273(0.73)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C263(0.83); C273(0.83)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C263(0.83); C273(0.83)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C263(1.00); C273(1.00)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C263(0.98); C273(0.98)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C263(1.30); C273(1.30)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C263(1.14); C273(1.14)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C263(1.12); C273(1.12)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C263(1.07); C273(1.07)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C263(0.79); C273(0.79)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C263(1.43); C273(1.43)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C263(1.04); C273(1.04)  LDD0624  [1]
 LDCM0312  AC5 HCT 116 C263(1.37); C273(1.37)  LDD0629  [1]
 LDCM0349  AC83 HCT 116 C263(2.49); C273(2.49)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C263(1.54); C273(1.54)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C263(1.54); C273(1.54)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C263(1.32); C273(1.32)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C263(2.21); C273(2.21)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C263(2.41); C273(2.41)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C263(2.28); C273(2.28)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C263(1.16); C273(1.16)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C263(1.99); C273(1.99)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C263(2.17); C273(2.17)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C263(1.79); C273(1.79)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C263(1.45); C273(1.45)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C263(2.03); C273(2.03)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C263(1.63); C273(1.63)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C263(2.88); C273(2.88)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C263(1.08); C273(1.08)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C263(0.62); C273(0.62)  LDD0683  [1]
 LDCM0020  ARS-1620 HCC44 C263(1.11); C273(1.11)  LDD2171  [1]
 LDCM0369  CL100 HCT 116 C263(1.14); C273(1.14)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C263(1.24); C273(1.24)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C263(1.53); C273(1.53)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C263(1.20); C273(1.20)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C263(1.46); C273(1.46)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C263(1.47); C273(1.47)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C263(1.51); C273(1.51)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C263(1.74); C273(1.74)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C263(1.27); C273(1.27)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C263(1.20); C273(1.20)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C263(1.43); C273(1.43)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C263(2.20); C273(2.20)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C263(1.42); C273(1.42)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C263(1.66); C273(1.66)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C263(0.97); C273(0.97)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C263(0.96); C273(0.96)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C263(0.88); C273(0.88)  LDD0708  [1]
 LDCM0403  CL16 HCT 116 C263(0.85); C273(0.85)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C263(0.71); C273(0.71)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C263(0.72); C273(0.72)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C263(0.73); C273(0.73)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C263(0.63); C273(0.63)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C263(1.91); C273(1.91)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C263(1.27); C273(1.27)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C263(0.93); C273(0.93)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C263(1.24); C273(1.24)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C263(0.92); C273(0.92)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C263(0.75); C273(0.75)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C263(0.67); C273(0.67)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C263(1.24); C273(1.24)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C263(0.83); C273(0.83)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C263(0.92); C273(0.92)  LDD0736  [1]
 LDCM0436  CL46 HCT 116 C263(1.30); C273(1.30)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C263(1.34); C273(1.34)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C263(1.01); C273(1.01)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C263(1.34); C273(1.34)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C263(1.48); C273(1.48)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C263(1.14); C273(1.14)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C263(0.96); C273(0.96)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C263(1.18); C273(1.18)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C263(1.06); C273(1.06)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C263(1.10); C273(1.10)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C263(1.48); C273(1.48)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C263(1.37); C273(1.37)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C263(0.90); C273(0.90)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C263(1.15); C273(1.15)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C263(2.25); C273(2.25)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C263(0.85); C273(0.85)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C263(0.78); C273(0.78)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C263(0.97); C273(0.97)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C263(1.28); C273(1.28)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C263(1.03); C273(1.03)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C263(1.54); C273(1.54)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C263(0.94); C273(0.94)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C263(0.99); C273(0.99)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C263(0.91); C273(0.91)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C263(1.00); C273(1.00)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C263(1.47); C273(1.47)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C263(0.84); C273(0.84)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C263(0.77); C273(0.77)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C263(1.24); C273(1.24)  LDD0784  [1]
 LDCM0486  CL91 HCT 116 C263(1.34); C273(1.34)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C263(1.12); C273(1.12)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C263(1.26); C273(1.26)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C263(1.32); C273(1.32)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C263(1.29); C273(1.29)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C263(1.09); C273(1.09)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C263(1.18); C273(1.18)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C263(1.48); C273(1.48)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C263(1.11); C273(1.11)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C263(1.31); C273(1.31)  LDD0785  [1]
 LDCM0021  THZ1 HCT 116 C263(1.11); C273(1.11)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Arfaptin-2 (ARFIP2) . P53365

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.