Details of the Target

General Information of Target

Target ID LDTP17747
Target Name Zinc finger protein 611 (ZNF611)
Gene Name ZNF611
Gene ID 81856
Synonyms
Zinc finger protein 611
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGPMRPRSASLVDFQFGVVATETIEDALLHLAQQNEQAVREASGRLGRFREPQIVEFVF
LLSEQWCLEKSVSYQAVEILERFMVKQAENICRQATIQPRDNKRESQNWRALKQQLVNKF
TLRLVSCVQLASKLSFRNKIISNITVLNFLQALGYLHTKEELLESELDVLKSLNFRINLP
TPLAYVETLLEVLGYNGCLVPAMRLHATCLTLLDLVYLLHEPIYESLLRASIENSTPSQL
QGEKFTSVKEDFMLLAVGIIAASAFIQNHECWSQVVGHLQSITGIALASIAEFSYAILTH
GVGANTPGRQQSIPPHLAARALKTVASSNT
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8N823
Ensemble ID
ENST00000319783.5
HGNC ID
HGNC:28766

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.C459R; p.S636F DBIA    Probe Info 
EFO27 SNV: p.V283A DBIA    Probe Info 
ICC10 Substitution: p.H585R DBIA    Probe Info 
ICC106 Substitution: p.H585R .
ICC108 Substitution: p.H585R DBIA    Probe Info 
JHH7 SNV: p.K350E .
MSTO211H SNV: p.F491C DBIA    Probe Info 
SW1271 SNV: p.K72N .
UACC257 SNV: p.C233Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C317(1.05); C320(1.05)  LDD0547  [1]
HHS-465
 Probe Info  		K368(0.00); K371(0.00); Y370(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C317(1.05); C320(1.05)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C317(1.07); C320(0.87)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C317(1.05); C320(0.83)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C317(0.98); C320(0.93)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C317(0.88); C320(0.90)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C317(0.98); C320(0.92)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C317(1.28); C320(0.91)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C317(1.08); C320(0.93)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C317(0.92); C320(0.87)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C317(1.25); C320(0.83)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C317(1.18); C320(0.88)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C317(0.90); C320(0.97)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C317(1.06); C320(0.93)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C317(1.18); C320(0.86)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C317(0.89); C320(0.89)  LDD0562  [1]
 LDCM0436  CL46 HCT 116 C317(1.17); C320(1.17)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C317(1.13); C320(1.13)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C317(1.09); C320(1.09)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C317(1.31); C320(1.31)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C317(1.07); C320(1.07)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C317(1.10); C320(1.10)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C317(1.04); C320(1.04)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C317(0.90); C320(0.90)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C317(1.04); C320(1.04)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C317(1.01); C320(1.01)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C317(0.90); C320(0.90)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C317(1.05); C320(1.05)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C317(0.96); C320(0.96)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C317(1.24); C320(1.24)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C317(1.00); C320(1.00)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C317(0.71); C320(0.71)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C317(0.81); C320(0.81)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C317(0.91); C320(0.91)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C317(1.03); C320(1.03)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C317(0.83); C320(0.83)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C317(1.00); C320(1.00)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C317(0.86); C320(0.86)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C317(0.67); C320(0.67)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C317(0.88); C320(0.88)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C317(0.74); C320(0.74)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C317(0.76); C320(0.76)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C317(0.97); C320(0.97)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C317(1.14); C320(1.14)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C317(0.91); C320(0.91)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C317(0.99); C320(0.99)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C317(0.93); C320(0.93)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C317(0.79); C320(0.79)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C317(0.92); C320(0.92)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C317(1.18); C320(1.18)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C317(0.85); C320(0.85)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C317(0.79); C320(0.79)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C317(0.83); C320(0.83)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C317(1.03); C320(1.03)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C317(0.87); C320(0.87)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C317(0.86); C320(0.86)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C317(0.88); C320(0.88)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C317(0.86); C320(0.86)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C317(0.97); C320(0.97)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C317(0.84); C320(0.84)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C317(0.93); C320(0.93)  LDD0785  [1]
 LDCM0022  KB02 22RV1 C549(3.99)  LDD2243  [3]
 LDCM0023  KB03 22RV1 C549(1.67)  LDD2660  [3]
 LDCM0024  KB05 HMCB C549(1.35)  LDD3312  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840