Details of the Target

General Information of Target

Target ID LDTP17558
Target Name F-box only protein 33 (FBXO33)
Gene Name FBXO33
Gene ID 254170
Synonyms
FBX33; F-box only protein 33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNVHRGSDSDRLLRQEASCLVDDTLAVAQEKEANSLASSGPHNLTYPLGPRNEDLSLDYA
SQPANLQFPHIMPLAEDIKGSCFQSGNKRNHEPFIAPERFGNSSVGFGSNSHSQAPEKVT
LLVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISATVFRTVLD
YYKTGIINCPDGISIPDLRDTCDYLCINFDFNTIRCQDLSALLHELSNDGAHKQFDHYLE
ELILPIMVGCAKKGERECHIVVLTDEDSVDWDEDHPPPMGEEYSQILYSSKLYRFFKYIE
NRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEG
KSRHVDFQCVRSKSLTNLVAAGDDVLEDQEILMHHPPQVDELDRLNAPLSQMASNDFQD
Target Bioclass
Other
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1.
Uniprot ID
Q7Z6M2
Ensemble ID
ENST00000298097.8
HGNC ID
HGNC:19833

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C101(0.78)  LDD1093  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C95(0.00); C316(0.00); C405(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C95(0.00); C101(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C101(0.00); C316(0.00); C405(0.00)  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C101(0.78)  LDD1093  [1]
 LDCM0259  AC14 HEK-293T C316(1.05)  LDD1512  [3]
 LDCM0279  AC2 PaTu 8988t C101(0.95)  LDD1158  [1]
 LDCM0282  AC22 HEK-293T C316(0.88)  LDD1521  [3]
 LDCM0290  AC3 PaTu 8988t C101(1.03)  LDD1169  [1]
 LDCM0291  AC30 HEK-293T C316(0.83)  LDD1530  [3]
 LDCM0296  AC35 PaTu 8988t C101(1.32)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C101(0.91)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C101(1.35)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C101(1.28)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C101(0.87)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C101(0.80)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C101(0.97)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C101(1.52)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C101(0.97)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C101(0.96)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C101(0.89)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C101(1.11)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C101(1.36)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C101(0.84)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C101(0.76)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C101(1.01)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C101(0.84)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C101(0.91)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C101(0.25)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C101(0.90)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C101(0.78)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C101(0.88)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C101(1.17)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C101(1.38)  LDD1198  [1]
 LDCM0323  AC6 HEK-293T C316(0.93)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C316(0.96)  LDD1565  [3]
 LDCM0332  AC68 PaTu 8988t C101(1.00)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C101(0.91)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C101(1.09)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C101(0.89)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C101(0.74)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C101(1.11)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C101(0.82)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C101(1.00)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C101(1.21)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C101(0.83)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C101(0.85)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C101(1.38)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C101(0.84)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C101(0.92)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C101(0.98)  LDD1227  [1]
 LDCM0367  CL1 HEK-293T C405(0.96)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C316(1.12)  LDD1572  [3]
 LDCM0369  CL100 PaTu 8988t C101(0.67)  LDD1248  [1]
 LDCM0370  CL101 HEK-293T C405(0.89)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C405(1.12)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C405(1.05)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C405(1.03)  LDD1587  [3]
 LDCM0387  CL117 PaTu 8988t C101(0.99)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C101(1.08)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C101(1.07)  LDD1268  [1]
 LDCM0391  CL120 PaTu 8988t C101(0.86)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C101(0.87)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C101(0.74)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C101(0.91)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C101(0.82)  LDD1274  [1]
 LDCM0396  CL125 HEK-293T C405(1.23)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C405(0.99)  LDD1604  [3]
 LDCM0403  CL16 PaTu 8988t C101(1.27)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C101(1.30)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C101(0.77)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C101(1.40)  LDD1285  [1]
 LDCM0408  CL20 PaTu 8988t C101(0.90)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C101(0.61)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C101(0.93)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C101(0.98)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C101(1.68)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C101(1.53)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C101(0.97)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C101(1.03)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C101(1.16)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C101(1.25)  LDD1296  [1]
 LDCM0419  CL30 PaTu 8988t C101(1.34)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C101(0.83)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C101(0.80)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C101(0.77)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C101(0.88)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C101(0.82)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C101(0.81)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C101(0.92)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C101(0.94)  LDD1307  [1]
 LDCM0430  CL40 PaTu 8988t C101(0.88)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C101(0.77)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C101(0.84)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C101(0.82)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C101(0.93)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C101(0.80)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C101(1.35)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C101(0.99)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C101(0.95)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C101(1.08)  LDD1318  [1]
 LDCM0441  CL50 PaTu 8988t C101(0.83)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C101(0.72)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C101(0.87)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C101(0.68)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C101(0.80)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C101(0.81)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C101(0.17)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C101(0.60)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C101(0.83)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C101(0.59)  LDD1329  [1]
 LDCM0452  CL60 PaTu 8988t C101(0.62)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C101(1.09)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C101(0.99)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C101(1.24)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C101(0.92)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C101(0.86)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C101(1.04)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C101(0.98)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C101(0.81)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C101(0.86)  LDD1340  [1]
 LDCM0463  CL70 PaTu 8988t C101(0.96)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C101(0.96)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C101(1.60)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C101(0.92)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C101(1.12)  LDD1346  [1]
 LDCM0476  CL82 HEK-293T C316(0.98)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C405(1.15)  LDD1682  [3]
 LDCM0486  CL91 PaTu 8988t C101(0.97)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C101(0.68)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C101(0.89)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C101(1.01)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C101(0.62)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C101(0.77)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C101(0.76)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C101(0.66)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C101(0.92)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C101(0.92)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C101(0.82)  LDD1306  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cullin-1 (CUL1) Cullin family Q13616
S-phase kinase-associated protein 1 (SKP1) SKP1 family P63208
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Y-box-binding protein 1 (YBX1) YBX1 family P67809

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402