Details of the Target

General Information of Target

Target ID LDTP17476
Target Name Protein C-mannosyl-transferase DPY19L3 (DPY19L3)
Gene Name DPY19L3
Gene ID 147991
Synonyms
Protein C-mannosyl-transferase DPY19L3; EC 2.4.1.-; Dpy-19-like protein 3; Protein dpy-19 homolog 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQATAVVETASGKGYHSNGGNLQKDKPSNPKKENLLLSSNGCDEVKLTFPDDDWNSSTLE
QRANNKEISNIDKMDLLEPFFSVSQDTNTESTQFQSSELEDSTDYAFLNKTYSIPYSESK
LKKESLTPLSSELDPEVQKKEEVFFNILEHQDKTVGLERIYNISDANYRESAEDTQKHDT
DEDSQQEYHSAEEQEYISNHLSFDQTKALDISNPEVVELGNSGYEVKCASNVEDNRVNSG
SGSIISFDSLDVYGQEESLHVSKFQNSVMLREYHDLKHEKYKEQETNSMYHTVFDGSVLR
SNSPGNQESQSKSGSLSPQKVLKMKIYTENMKSQINEGKDFCGNKIVENKILLHLENPST
LPQDKALETLLQPCKDCQTSWTSVFDDSIISACGYYESLQNTADSALDFSAMLPKIAVRD
NQAIEDNTSLKVAHSSTTKKTCFHNIGEMCTKSLTDAASCTVTINQTVDVSTDFRACFTT
SRATSARPSVVSTSSNTEITMMNKKRPDEWQNEKQKSVACSTDWSYSEDCIDTQMAITKG
SGKSLSVDSLKPNGNFLNKDFLELRKACGITDLKKHPEREFQLFKDTEKDLPSMCCQKIM
QRAIKAELHLLNVHYQMCRRHCCDIYKLVMENREGLNMNLSSNSAKKELGSALLSLLGDL
KVRYVTLKEKIHKGIPLEELPPLSLESKLLSTFSTFASRLMKKETHVFSEADAEQDNQRA
HDVDVSSNLKKTLSQMSLSSDNSHATQNISPKKDDFKNGDINADFSQLKLGDKDCRHYQE
TSEDWSDAKESLTGVDVSGTQGNQVEQDTWNLDLTGEMKNVEPSQRDKGYLIHVGGLCPS
VSEADLRSHFQKYQVSEISIYDSTNYRYASLAFTKNSDAKIAVKEMNGIEINGKSVNVWP
VKILGEYTSPLSSKNGNRISSNNLEKSTNKQIHSEFSISRLPRTRPRQLGSEQDSEVFPS
DQGVKKNCKQIESAKLLPDTPVQFIPPNTLNLRSFTKIIKRLAELHPEVSRDHIINALQE
VRIRHKGFLNGLSITTIVEMTSSLLKNSASS
Target Bioclass
Enzyme
Family
Dpy-19 family
Subcellular location
Membrane
Function
C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence. C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW. C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence.; [Isoform 2]: Has no C-mannosyltransferase activity.
Uniprot ID
Q6ZPD9
Ensemble ID
ENST00000342179.9
HGNC ID
HGNC:27120

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L341P DBIA    Probe Info 
CORL88 SNV: p.V512I .
HT115 SNV: p.L384R .
MCAS SNV: p.L181R DBIA    Probe Info 
SNGM SNV: p.M101I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		7.40  LDD0196  [1]
IPM
 Probe Info  		C684(13.70)  LDD1701  [2]
DBIA
 Probe Info  		C91(1.18)  LDD0078  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C91(1.03)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C91(0.93)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C91(1.01)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C91(1.03)  LDD1510  [4]
 LDCM0276  AC17 HEK-293T C91(1.16)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C91(0.95)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C91(1.08)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C91(0.87)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C91(1.02)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C91(1.29)  LDD1520  [4]
 LDCM0284  AC24 HEK-293T C91(1.03)  LDD1523  [4]
 LDCM0285  AC25 PaTu 8988t C91(0.90)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C91(0.82)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C91(0.78)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C91(0.80)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C91(0.72)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C91(1.05)  LDD1529  [4]
 LDCM0291  AC30 PaTu 8988t C91(0.96)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C91(0.93)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C91(1.00)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C91(0.86)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C91(0.90)  LDD1174  [3]
 LDCM0296  AC35 HEK-293T C91(1.08)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C91(1.15)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C91(1.06)  LDD1537  [4]
 LDCM0301  AC4 HEK-293T C91(1.07)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C91(1.10)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C91(1.08)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C91(0.87)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C91(1.04)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C91(1.15)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C91(1.02)  LDD1546  [4]
 LDCM0308  AC46 PaTu 8988t C91(0.98)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C91(1.27)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C91(1.22)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C91(1.06)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C91(1.01)  LDD1551  [4]
 LDCM0313  AC50 PaTu 8988t C91(1.19)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C91(0.86)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C91(1.72)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C91(1.00)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C91(1.07)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C91(0.99)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C91(4.55)  LDD1198  [3]
 LDCM0320  AC57 HEK-293T C91(1.02)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C91(0.86)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C91(1.16)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C91(1.01)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C91(1.17)  LDD1564  [4]
 LDCM0328  AC64 HEK-293T C91(1.04)  LDD1567  [4]
 LDCM0332  AC68 PaTu 8988t C91(0.73)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C91(0.71)  LDD1212  [3]
 LDCM0335  AC70 PaTu 8988t C91(0.59)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C91(0.90)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C91(1.11)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C91(0.85)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C91(0.84)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C91(0.65)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C91(0.81)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C91(0.78)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C91(0.70)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C91(0.68)  LDD1223  [3]
 LDCM0345  AC8 HEK-293T C91(1.14)  LDD1569  [4]
 LDCM0346  AC80 PaTu 8988t C91(0.77)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C91(0.64)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C91(0.66)  LDD1227  [3]
 LDCM0248  AKOS034007472 HEK-293T C91(1.14)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C91(1.04)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C91(1.28)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C91(1.18)  LDD0078  [3]
 LDCM0371  CL102 HEK-293T C91(1.42)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C91(0.96)  LDD1579  [4]
 LDCM0380  CL110 HEK-293T C91(1.40)  LDD1584  [4]
 LDCM0382  CL112 PaTu 8988t C91(0.97)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C91(0.90)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C91(0.91)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C91(0.92)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C91(1.52)  LDD1265  [3]
 LDCM0388  CL118 HEK-293T C91(1.07)  LDD1592  [4]
 LDCM0390  CL12 HEK-293T C91(1.95)  LDD1594  [4]
 LDCM0392  CL121 PaTu 8988t C91(1.13)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C91(20.00)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C91(1.26)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C91(1.51)  LDD1274  [3]
 LDCM0397  CL126 HEK-293T C91(1.22)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C91(1.19)  LDD1605  [4]
 LDCM0404  CL17 HEK-293T C91(1.68)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C91(1.11)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C91(1.22)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C91(1.16)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C91(1.19)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C91(1.30)  LDD1613  [4]
 LDCM0412  CL24 HEK-293T C91(1.55)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C91(1.04)  LDD1618  [4]
 LDCM0417  CL29 HEK-293T C91(1.10)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C91(1.17)  LDD1623  [4]
 LDCM0420  CL31 PaTu 8988t C91(0.87)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C91(0.65)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C91(0.76)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C91(0.66)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C91(0.77)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C91(0.72)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C91(0.63)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C91(0.61)  LDD1307  [3]
 LDCM0430  CL40 PaTu 8988t C91(0.70)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C91(0.66)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C91(0.66)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C91(0.68)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C91(0.62)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C91(0.84)  LDD1314  [3]
 LDCM0438  CL48 HEK-293T C91(1.86)  LDD1642  [4]
 LDCM0440  CL5 HEK-293T C91(1.14)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C91(1.18)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C91(1.54)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C91(1.67)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C91(1.49)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C91(1.19)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C91(1.39)  LDD1651  [4]
 LDCM0451  CL6 HEK-293T C91(1.46)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C91(1.42)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C91(1.20)  LDD1657  [4]
 LDCM0457  CL65 HEK-293T C91(1.10)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C91(1.00)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C91(1.25)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C91(1.19)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C91(1.16)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C91(1.33)  LDD1665  [4]
 LDCM0465  CL72 HEK-293T C91(1.73)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C91(1.22)  LDD1670  [4]
 LDCM0469  CL76 PaTu 8988t C91(0.47)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C91(0.55)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C91(0.37)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C91(0.42)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C91(3.16)  LDD1676  [4]
 LDCM0474  CL80 PaTu 8988t C91(0.42)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C91(0.74)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C91(0.76)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C91(0.43)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C91(0.43)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C91(0.48)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C91(0.39)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C91(0.44)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C91(0.62)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C91(0.33)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C91(1.34)  LDD1687  [4]
 LDCM0485  CL90 PaTu 8988t C91(0.38)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C91(1.27)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C91(1.40)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C91(1.39)  LDD1691  [4]
 LDCM0491  CL96 HEK-293T C91(1.89)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C91(1.26)  LDD1696  [4]
 LDCM0427  Fragment51 PaTu 8988t C91(0.76)  LDD1306  [3]
 LDCM0022  KB02 HCT 116 C91(1.32)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C91(1.14)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C91(0.93)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402