Details of the Target

General Information of Target

Target ID LDTP17390
Target Name BTB/POZ domain-containing protein KCTD18 (KCTD18)
Gene Name KCTD18
Gene ID 130535
Synonyms
BTB/POZ domain-containing protein KCTD18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSATRAKKVKMATKSCPECDQQVPVACKSCPCGYIFISRKLLNAKHSEKSPPSTENKHEA
KRRRTERVRREKINSTVNKDLENRKRSRSNSHSDHIRRGRGRPKSASAKKHEEEREKQEK
EIDIYANLSDEKAFVFSVALAEINRKIINQRLIL
Target Bioclass
Other
Uniprot ID
Q6PI47
Ensemble ID
ENST00000359878.8
HGNC ID
HGNC:26446

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.L279WfsTer98 .
Ishikawa (Heraklio) 02 ER SNV: p.A309V DBIA    Probe Info 
JURKAT SNV: p.W235Ter .
MEWO SNV: p.S104F .
MOLT4 SNV: p.R32H; p.A87T IA-alkyne    Probe Info 
NUGC3 SNV: p.A311T .
OVISE SNV: p.F314L .
SW1783 SNV: p.G178R .
TC71 SNV: p.N138S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C390(3.18)  LDD0168  [1]
DBIA
 Probe Info  		C385(3.27); C390(3.27)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C390(3.18)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C390(5.78)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C56(1.22)  LDD0812  [2]
 LDCM0226  AC11 HEK-293T C21(0.97)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C21(1.09)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C21(0.89)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C21(1.09)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C56(1.28)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C56(1.21)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C56(1.18)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C56(1.04)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C56(1.05)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C56(1.20)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C56(1.14)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C56(1.07)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C56(1.09)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C56(1.23)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C56(1.20)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C56(1.07)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C56(1.35)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C56(1.09)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C56(0.97)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C56(1.09)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C56(1.03)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C56(1.17)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C56(1.09)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C56(1.05)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C21(0.98)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C21(1.17)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C21(1.04)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C21(1.07)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C56(1.36)  LDD0899  [2]
 LDCM0303  AC41 HEK-293T C21(1.03)  LDD1542  [5]
 LDCM0305  AC43 HEK-293T C21(0.94)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C21(1.15)  LDD1545  [5]
 LDCM0308  AC46 HEK-293T C21(0.95)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C21(1.16)  LDD1548  [5]
 LDCM0311  AC49 HEK-293T C21(0.96)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C56(1.24)  LDD0910  [2]
 LDCM0314  AC51 HEK-293T C21(0.93)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C21(1.06)  LDD1554  [5]
 LDCM0317  AC54 HEK-293T C21(0.98)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C21(0.97)  LDD1557  [5]
 LDCM0320  AC57 HEK-293T C56(1.06)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C56(0.96)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C56(0.92)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C21(0.94)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C56(0.84)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C56(0.95)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C56(0.81)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C56(0.98)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C56(0.84)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C56(0.91)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C56(0.86)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C56(0.92)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C56(1.17)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C56(1.22)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C21(1.00)  LDD1568  [5]
 LDCM0335  AC70 HEK-293T C56(1.29)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C56(1.44)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C56(1.57)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C56(1.33)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C56(1.77)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C56(1.54)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C56(1.42)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C56(1.32)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C56(1.27)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C56(1.43)  LDD0942  [2]
 LDCM0346  AC80 HEK-293T C56(1.51)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C56(1.53)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C56(1.86)  LDD0946  [2]
 LDCM0356  AKOS034007680 HEK-293T C21(1.05)  LDD1570  [5]
 LDCM0020  ARS-1620 HCC44 C385(1.14); C390(1.14)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C21(1.06)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C21(0.86)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C56(1.40)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C21(1.08)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C21(0.97)  LDD1576  [5]
 LDCM0374  CL105 HEK-293T C56(1.16)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C56(1.16)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C56(1.25)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C56(1.17)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C56(1.10)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C21(1.01)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C56(1.08)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C56(0.96)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C56(0.94)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C56(0.96)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C56(1.10)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C56(1.19)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C56(1.25)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C21(1.15)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C21(1.05)  LDD1593  [5]
 LDCM0392  CL121 HEK-293T C21(1.07)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C21(0.84)  LDD1598  [5]
 LDCM0396  CL125 HEK-293T C56(1.13)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C56(0.92)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C56(1.08)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C56(1.13)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C21(1.05)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C21(1.03)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C56(0.92)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C56(0.75)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C56(1.14)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C56(1.04)  LDD1004  [2]
 LDCM0408  CL20 HEK-293T C56(0.92)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C56(0.93)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C56(0.85)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C56(0.80)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C56(0.89)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C56(0.85)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C56(0.82)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C56(0.95)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C56(0.83)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C56(0.91)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C21(0.95)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C56(0.95)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C21(0.94)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C21(1.01)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C21(0.89)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C21(0.97)  LDD1628  [5]
 LDCM0426  CL37 HEK-293T C21(1.17)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C21(0.95)  LDD1632  [5]
 LDCM0431  CL41 HEK-293T C21(1.01)  LDD1635  [5]
 LDCM0433  CL43 HEK-293T C21(0.92)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C21(1.12)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C21(0.98)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C21(1.04)  LDD1641  [5]
 LDCM0439  CL49 HEK-293T C21(1.21)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C21(1.11)  LDD1644  [5]
 LDCM0444  CL53 HEK-293T C21(0.98)  LDD1647  [5]
 LDCM0446  CL55 HEK-293T C21(0.89)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C21(1.14)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C21(0.85)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C21(1.05)  LDD1653  [5]
 LDCM0453  CL61 HEK-293T C21(1.17)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C21(0.99)  LDD1658  [5]
 LDCM0457  CL65 HEK-293T C21(1.04)  LDD1660  [5]
 LDCM0459  CL67 HEK-293T C21(0.94)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C21(1.29)  LDD1663  [5]
 LDCM0462  CL7 HEK-293T C21(0.93)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C21(0.95)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C21(1.19)  LDD1667  [5]
 LDCM0466  CL73 HEK-293T C21(1.08)  LDD1669  [5]
 LDCM0470  CL77 HEK-293T C21(1.07)  LDD1673  [5]
 LDCM0472  CL79 HEK-293T C21(0.99)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C21(0.92)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C21(1.12)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C21(0.95)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C21(1.05)  LDD1680  [5]
 LDCM0479  CL85 HEK-293T C21(1.23)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C21(1.12)  LDD1684  [5]
 LDCM0483  CL89 HEK-293T C21(1.05)  LDD1686  [5]
 LDCM0486  CL91 HEK-293T C56(1.35)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C56(1.09)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C56(1.11)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C56(1.43)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C56(1.50)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C56(1.37)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C56(1.45)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C56(1.30)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C56(1.32)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C21(0.98)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C21(0.99)  LDD1671  [5]
 LDCM0022  KB02 HCT 116 C385(3.27); C390(3.27)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C385(1.40); C390(1.40)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C385(2.41); C390(2.41)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C385(1.14); C390(1.14)  LDD2173  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402