Details of the Target

General Information of Target

Target ID LDTP16174
Target Name Armadillo repeat-containing X-linked protein 1 (ARMCX1)
Gene Name ARMCX1
Gene ID 51309
Synonyms
ALEX1; Armadillo repeat-containing X-linked protein 1; ARM protein lost in epithelial cancers on chromosome X 1; Protein ALEX1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYSPQTQETD
SAVQKELRNQTPAPSAAQTSAPSKYHRTRSGGARDERYRSDIHTEAVQAALAKHKEQKMA
LPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQ
GSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSAPPDVTTTTSSSSSSSSIRPANI
DLPPSGIVKGMHKGSNRSSLMDTADGVPVSSRVSTKIQQLLNTLKRPKRPPLKEFFVDDS
EEIVEVPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGTTQAKCSCLTALD
MTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFY
GCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFK
GWPRLKWVVTDSKYLSKPPKDWQPHISPAGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHC
QALSQACNYSEGETIVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRV
HAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSH
GLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTV
QDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVN
SAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKT
VYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVP
ANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVG
NLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCT
ASCLQLHKRAERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPH
AQNLTATLPTVRMIVDVSKAACILTSQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKR
LPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLD
PYCGLGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTK
GLGNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRV
NVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPE
TKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGF
VRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTN
LLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRD
SFLADQLDPIYVAYNM
Target Bioclass
Other
Family
Eutherian X-chromosome-specific Armcx family
Subcellular location
Mitochondrion
Function
Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.
Uniprot ID
Q9P291
Ensemble ID
ENST00000372829.8
HGNC ID
HGNC:18073

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K116(3.23)  LDD0277  [1]
DBIA
 Probe Info  		C144(2.75)  LDD3310  [2]
IPM
 Probe Info  		C144(2.05); C152(1.66)  LDD1701  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C292(1.09); C298(1.09)  LDD1094  [6]
 LDCM0226  AC11 PaTu 8988t C292(1.23); C298(1.23)  LDD1105  [6]
 LDCM0237  AC12 PaTu 8988t C292(1.11); C298(1.11)  LDD1116  [6]
 LDCM0259  AC14 PaTu 8988t C292(1.39); C298(1.39)  LDD1138  [6]
 LDCM0270  AC15 PaTu 8988t C292(1.08); C298(1.08)  LDD1149  [6]
 LDCM0285  AC25 PaTu 8988t C292(0.80); C298(0.80)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C292(0.86); C298(0.86)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C292(0.66); C298(0.66)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C292(0.82); C298(0.82)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C292(0.67); C298(0.67)  LDD1168  [6]
 LDCM0291  AC30 PaTu 8988t C292(0.88); C298(0.88)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C292(0.70); C298(0.70)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C292(0.64); C298(0.64)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C292(0.95); C298(0.95)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C292(0.98); C298(0.98)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C292(0.89); C298(0.89)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C292(0.72); C298(0.72)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C292(0.81); C298(0.81)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C292(0.71); C298(0.71)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C292(0.80); C298(0.80)  LDD1179  [6]
 LDCM0302  AC40 PaTu 8988t C292(0.82); C298(0.82)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C292(0.95); C298(0.95)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C292(0.83); C298(0.83)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C292(0.98); C298(0.98)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C292(1.15); C298(1.15)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C292(0.85); C298(0.85)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C292(0.97); C298(0.97)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C292(0.86); C298(0.86)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C292(0.89); C298(0.89)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C292(0.81); C298(0.81)  LDD1190  [6]
 LDCM0313  AC50 PaTu 8988t C292(1.06); C298(1.06)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C292(0.22); C298(0.22)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C292(0.79); C298(0.79)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C292(0.99); C298(0.99)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C292(1.19); C298(1.19)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C292(0.93); C298(0.93)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C292(1.04); C298(1.04)  LDD1198  [6]
 LDCM0323  AC6 PaTu 8988t C292(1.06); C298(1.06)  LDD1202  [6]
 LDCM0332  AC68 PaTu 8988t C292(1.14); C298(1.14)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C292(1.14); C298(1.14)  LDD1212  [6]
 LDCM0334  AC7 PaTu 8988t C292(1.00); C298(1.00)  LDD1213  [6]
 LDCM0335  AC70 PaTu 8988t C292(1.08); C298(1.08)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C292(1.14); C298(1.14)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C292(0.88); C298(0.88)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C292(0.89); C298(0.89)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C292(1.69); C298(1.69)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C292(1.25); C298(1.25)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C292(1.31); C298(1.31)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C292(1.05); C298(1.05)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C292(1.51); C298(1.51)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C292(1.11); C298(1.11)  LDD1223  [6]
 LDCM0345  AC8 PaTu 8988t C292(0.93); C298(0.93)  LDD1224  [6]
 LDCM0346  AC80 PaTu 8988t C292(1.09); C298(1.09)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C292(1.00); C298(1.00)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C292(0.97); C298(0.97)  LDD1227  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C292(1.10); C298(1.10)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C292(1.27); C298(1.27)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C292(1.21); C298(1.21)  LDD1154  [6]
 LDCM0370  CL101 PaTu 8988t C292(1.01); C298(1.01)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C292(0.91); C298(0.91)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C292(1.18); C298(1.18)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C292(1.09); C298(1.09)  LDD1252  [6]
 LDCM0382  CL112 PaTu 8988t C292(0.86); C298(0.86)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C292(0.78); C298(0.78)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C292(0.69); C298(0.69)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C292(0.73); C298(0.73)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C292(0.72); C298(0.72)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C292(0.77); C298(0.77)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C292(0.69); C298(0.69)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C292(0.87); C298(0.87)  LDD1268  [6]
 LDCM0391  CL120 PaTu 8988t C292(0.50); C298(0.50)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C292(0.99); C298(0.99)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C292(0.88); C298(0.88)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C292(0.89); C298(0.89)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C292(0.86); C298(0.86)  LDD1274  [6]
 LDCM0403  CL16 PaTu 8988t C298(1.12)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C298(1.07)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C298(1.42)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C298(1.14)  LDD1285  [6]
 LDCM0408  CL20 PaTu 8988t C298(1.31)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C298(1.59)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C298(1.40)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C298(1.41)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C298(1.32)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C298(1.32)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C298(1.32)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C298(1.61)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C298(1.79)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C298(1.25)  LDD1296  [6]
 LDCM0419  CL30 PaTu 8988t C298(1.82)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C292(1.02); C298(1.02)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C292(0.98); C298(0.98)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C292(1.13); C298(1.13)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C292(1.30); C298(1.30)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C298(1.01); C292(1.01)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C292(0.80); C298(0.80)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C292(1.12); C298(1.12)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C292(0.84); C298(0.84)  LDD1307  [6]
 LDCM0430  CL40 PaTu 8988t C292(0.94); C298(0.94)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C292(1.04); C298(1.04)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C292(1.22); C298(1.22)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C292(1.50); C298(1.50)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C292(1.09); C298(1.09)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C292(0.78); C298(0.78)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C292(1.07); C298(1.07)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C292(0.91); C298(0.91)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C292(0.97); C298(0.97)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C292(0.79); C298(0.79)  LDD1318  [6]
 LDCM0441  CL50 PaTu 8988t C292(0.93); C298(0.93)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C292(1.48); C298(1.48)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C292(0.88); C298(0.88)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C292(1.07); C298(1.07)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C292(0.91); C298(0.91)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C292(1.06); C298(1.06)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C292(1.42); C298(1.42)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C292(2.07); C298(2.07)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C292(0.99); C298(0.99)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C292(2.00); C298(2.00)  LDD1329  [6]
 LDCM0452  CL60 PaTu 8988t C292(1.11); C298(1.11)  LDD1331  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C144(1.06); C152(1.05)  LDD1702  [3]
 LDCM0427  Fragment51 PaTu 8988t C292(1.05); C298(1.05)  LDD1306  [6]
 LDCM0022  KB02 42-MG-BA C144(1.14)  LDD2244  [2]
 LDCM0023  KB03 MDA-MB-231 C144(2.05); C152(1.66)  LDD1701  [3]
 LDCM0024  KB05 COLO792 C144(2.75)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coilin (COIL) Coilin family P38432
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.