Details of the Target

General Information of Target

Target ID LDTP15815
Target Name 1-aminocyclopropane-1-carboxylate synthase-like protein 1 (ACCS)
Gene Name ACCS
Gene ID 84680
Synonyms
PHACS; 1-aminocyclopropane-1-carboxylate synthase-like protein 1; ACC synthase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPWSRVRVAKCQMLVTCFFILLLGLSVATMVTLTYFGAHFAVIRRASLEKNPYQAVHQW
AFSAGLSLVGLLTLGAVLSAAATVREAQGLMAGGFLCFSLAFCAQVQVVFWRLHSPTQVE
DAMLDTYDLVYEQAMKGTSHVRRQELAAIQDVFLCCGKKSPFSRLGSTEADLCQGEEAAR
EDCLQGIRSFLRTHQQVASSLTSIGLALTVSALLFSSFLWFAIRCGCSLDRKGKYTLTPR
ACGRQPQEPSLLRCSQGGPTHCLHSEAVAIGPRGCSGSLRWLQESDAAPLPLSCHLAAHR
ALQGRSRGGLSGCPERGLSD
Target Bioclass
Enzyme
Family
Class-I pyridoxal-phosphate-dependent aminotransferase family
Function Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine.
Uniprot ID
Q96QU6
Ensemble ID
ENST00000263776.9
HGNC ID
HGNC:23989

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L108F .
IGROV1 Insertion: p.T19HfsTer9 .
IM95 SNV: p.P226S .
MEWO SNV: p.Q463Ter .
NB1 SNV: p.S175F .
OVK18 SNV: p.E244D .
SKMEL3 SNV: p.L330F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C468(1.39)  LDD3334  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 PaTu 8988t C109(1.11)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C109(0.81)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C109(0.91)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C109(0.94)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C109(0.96)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C109(1.00)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C109(1.11)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C109(0.95)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C109(0.93)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C109(1.09)  LDD1104  [2]
 LDCM0227  AC110 PaTu 8988t C109(0.95)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C109(1.32)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C109(0.94)  LDD1108  [2]
 LDCM0230  AC113 PaTu 8988t C109(0.97)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C109(0.94)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C109(0.96)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C109(1.19)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C109(0.95)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C109(1.04)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C109(0.96)  LDD1115  [2]
 LDCM0237  AC12 HEK-293T C109(0.96)  LDD1510  [3]
 LDCM0238  AC120 PaTu 8988t C109(1.12)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C109(1.09)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C109(1.07)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C109(0.94)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C109(1.11)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C109(1.15)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C109(1.03)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C109(1.39)  LDD1124  [2]
 LDCM0276  AC17 PaTu 8988t C109(1.19)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C109(1.08)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C109(1.20)  LDD1157  [2]
 LDCM0280  AC20 PaTu 8988t C109(1.03)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C109(1.30)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C109(1.30)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C109(1.55)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C109(1.15)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C109(1.02)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C109(1.17)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C109(1.21)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C109(1.06)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C109(0.96)  LDD1168  [2]
 LDCM0291  AC30 PaTu 8988t C109(1.19)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C109(0.96)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C109(1.80)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C109(1.11)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C109(1.35)  LDD1174  [2]
 LDCM0297  AC36 HEK-293T C109(1.11)  LDD1536  [3]
 LDCM0301  AC4 HEK-293T C109(1.09)  LDD1540  [3]
 LDCM0306  AC44 HEK-293T C109(1.31)  LDD1545  [3]
 LDCM0308  AC46 PaTu 8988t C109(1.04)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C109(1.16)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C109(1.40)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C109(1.41)  LDD1190  [2]
 LDCM0313  AC50 PaTu 8988t C109(1.62)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C109(1.23)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C109(1.04)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C109(1.76)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C109(1.57)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C109(1.12)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C109(1.22)  LDD1198  [2]
 LDCM0320  AC57 PaTu 8988t C109(0.93)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C109(1.04)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C109(1.08)  LDD1201  [2]
 LDCM0324  AC60 PaTu 8988t C109(1.38)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C109(1.15)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C109(1.01)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C109(1.21)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C109(1.12)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C109(1.03)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C109(0.88)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C109(0.90)  LDD1210  [2]
 LDCM0332  AC68 PaTu 8988t C109(0.70)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C109(0.89)  LDD1212  [2]
 LDCM0335  AC70 PaTu 8988t C109(0.90)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C109(0.72)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C109(0.87)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C109(1.18)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C109(0.72)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C109(0.68)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C109(0.78)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C109(1.24)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C109(0.78)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C109(0.89)  LDD1223  [2]
 LDCM0346  AC80 PaTu 8988t C109(0.62)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C109(0.89)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C109(1.43)  LDD1227  [2]
 LDCM0365  AC98 PaTu 8988t C109(0.97)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C109(1.03)  LDD1245  [2]
 LDCM0374  CL105 PaTu 8988t C109(1.02)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C109(1.24)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C109(0.87)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C109(1.24)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C109(1.07)  LDD1257  [2]
 LDCM0380  CL110 PaTu 8988t C109(1.24)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C109(1.49)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C109(1.07)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C109(1.14)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C109(0.98)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C109(0.87)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C109(0.77)  LDD1265  [2]
 LDCM0392  CL121 PaTu 8988t C109(1.42)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C109(1.83)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C109(2.59)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C109(1.71)  LDD1274  [2]
 LDCM0396  CL125 PaTu 8988t C109(1.42)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C109(1.43)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C109(1.02)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C109(1.07)  LDD1278  [2]
 LDCM0408  CL20 HEK-293T C109(1.23)  LDD1612  [3]
 LDCM0420  CL31 PaTu 8988t C109(1.44)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C109(1.01)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C109(1.22)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C109(1.21)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C109(1.49)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C109(0.92)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C109(1.33)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C109(1.65)  LDD1307  [2]
 LDCM0430  CL40 PaTu 8988t C109(1.07)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C109(1.32)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C109(1.65)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C109(1.44)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C109(1.18)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C109(1.41)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C109(1.18)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C109(1.27)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C109(0.97)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C109(1.06)  LDD1318  [2]
 LDCM0441  CL50 PaTu 8988t C109(1.68)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C109(1.20)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C109(1.02)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C109(1.18)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C109(1.20)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C109(1.18)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C109(1.21)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C109(1.41)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C109(1.25)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C109(1.19)  LDD1329  [2]
 LDCM0452  CL60 PaTu 8988t C109(1.07)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C109(0.93)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C109(0.90)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C109(0.97)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C109(1.25)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C109(1.27)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C109(1.12)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C109(1.31)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C109(1.34)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C109(1.32)  LDD1340  [2]
 LDCM0463  CL70 PaTu 8988t C109(1.32)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C109(1.03)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C109(1.01)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C109(1.16)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C109(1.04)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C109(0.77)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C109(1.53)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C109(0.99)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C109(1.16)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C109(1.54)  LDD1676  [3]
 LDCM0474  CL80 PaTu 8988t C109(1.25)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C109(1.36)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C109(1.12)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C109(1.29)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C109(1.19)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C109(1.02)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C109(1.49)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C109(1.15)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C109(1.31)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C109(1.41)  LDD1362  [2]
 LDCM0485  CL90 PaTu 8988t C109(1.72)  LDD1364  [2]
 LDCM0487  CL92 HEK-293T C109(0.92)  LDD1690  [3]
 LDCM0468  Fragment33 PaTu 8988t C109(1.33)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C109(1.29)  LDD1306  [2]
 LDCM0022  KB02 697 C468(0.96)  LDD2245  [1]
 LDCM0023  KB03 786-O C468(1.59)  LDD2664  [1]
 LDCM0024  KB05 MOLM-16 C468(1.39)  LDD3334  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-aminocyclopropane-1-carboxylate synthase-like protein 1 (ACCS) Class-I pyridoxal-phosphate-dependent aminotransferase family Q96QU6
Cytochrome b-c1 complex subunit 7 (UQCRB) UQCRB/QCR7 family P14927

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vinylglycine . DB03214

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402