Details of the Target

General Information of Target

Target ID LDTP15721
Target Name Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)
Gene Name PHYHIPL
Gene ID 84457
Synonyms
KIAA1796; Phytanoyl-CoA hydroxylase-interacting protein-like
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEPAPGLVEQPKCLEAGSPEPEPAPWQALPVLSEKQSGDVELVLAYAAPVLDKRQTSRLL
KEVSALHPLPAQPHLKRVRPSRDAGSPHALEMLLCLAGPASGPRSLAELLPRPAVDPRGL
GQPFLVPVPARPPLTRGQFEEARAHWPTSFHEDKQVTSALAGRLFSTQERAAMQSHMERA
VWAARRAAARGLRAVGAVVVDPASDRVLATGHDCSCADNPLLHAVMVCVDLVARGQGRGT
YDFRPFPACSFAPAAAPQAVRAGAVRKLDADEDGLPYLCTGYDLYVTREPCAMCAMALVH
ARILRVFYGAPSPDGALGTRFRIHARPDLNHRFQVFRGVLEEQCRWLDPDT
Target Bioclass
Other
Family
PHYHIP family
Function May play a role in the development of the central system.
Uniprot ID
Q96FC7
Ensemble ID
ENST00000373878.3
HGNC ID
HGNC:29378

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S25G; p.R299H .
COLO679 SNV: p.S245L .
FADU SNV: p.E226Ter .
Ishikawa (Heraklio) 02 ER SNV: p.K67E DBIA    Probe Info 
KATOIII SNV: p.H202L .
SNGM SNV: p.A159T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IPM
 Probe Info  		C17(0.00); C370(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C32(1.76); C370(1.59)  LDD3333  [3]
W1
 Probe Info  		C17(0.00); C63(0.00); C32(0.00); C370(0.00)  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C63(1.06)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C63(1.10)  LDD1508  [4]
 LDCM0237  AC12 HEK-293T C63(0.92)  LDD1510  [4]
 LDCM0276  AC17 HEK-293T C63(0.91)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C63(1.08)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C63(1.08)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C63(1.04)  LDD1519  [4]
 LDCM0284  AC24 HEK-293T C63(1.07)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C63(0.90)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C63(1.00)  LDD1525  [4]
 LDCM0288  AC28 HEK-293T C63(0.87)  LDD1527  [4]
 LDCM0293  AC32 HEK-293T C63(0.90)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C63(1.01)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C63(1.04)  LDD1534  [4]
 LDCM0297  AC36 HEK-293T C63(1.00)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C63(1.04)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C63(0.89)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C63(1.00)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C63(1.01)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C63(0.89)  LDD1545  [4]
 LDCM0310  AC48 HEK-293T C63(0.98)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C63(1.02)  LDD1550  [4]
 LDCM0313  AC50 HEK-293T C63(1.00)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C63(1.00)  LDD1554  [4]
 LDCM0319  AC56 HEK-293T C63(1.02)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C63(1.05)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C63(1.01)  LDD1560  [4]
 LDCM0324  AC60 HEK-293T C63(0.90)  LDD1563  [4]
 LDCM0328  AC64 HEK-293T C63(0.94)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C63(0.97)  LDD1569  [4]
 LDCM0356  AKOS034007680 HEK-293T C63(1.02)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C63(0.90)  LDD1514  [4]
 LDCM0369  CL100 HEK-293T C63(0.91)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C63(0.89)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C63(0.89)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C63(1.34)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C63(0.94)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C63(0.97)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C63(0.91)  LDD1581  [4]
 LDCM0380  CL110 HEK-293T C63(0.89)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C63(0.89)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C63(1.11)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C63(0.92)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C63(0.93)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C63(1.04)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C63(0.91)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C63(0.77)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C63(1.25)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C63(1.02)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C63(0.90)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C63(0.77)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C63(1.11)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C63(0.96)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C63(0.93)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C63(0.90)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C63(0.93)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C63(0.85)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C63(1.08)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C63(0.83)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C63(1.07)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C63(1.03)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C63(1.07)  LDD1612  [4]
 LDCM0412  CL24 HEK-293T C63(1.07)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C63(0.92)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C63(0.93)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C63(0.97)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C63(1.03)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C63(1.08)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C63(1.00)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C63(0.95)  LDD1625  [4]
 LDCM0425  CL36 HEK-293T C63(1.05)  LDD1629  [4]
 LDCM0428  CL39 HEK-293T C63(0.96)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C63(0.91)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C63(1.01)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C63(0.87)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C63(1.05)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C63(0.94)  LDD1638  [4]
 LDCM0438  CL48 HEK-293T C63(0.92)  LDD1642  [4]
 LDCM0440  CL5 HEK-293T C63(0.97)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C63(0.92)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C63(0.91)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C63(0.88)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C63(1.12)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C63(1.08)  LDD1650  [4]
 LDCM0451  CL6 HEK-293T C63(1.22)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C63(0.90)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C63(1.02)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C63(1.17)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C63(0.75)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C63(1.12)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C63(0.98)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C63(0.97)  LDD1663  [4]
 LDCM0465  CL72 HEK-293T C63(0.95)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C63(0.86)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C63(1.07)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C63(0.94)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C63(0.96)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C63(0.80)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C63(1.06)  LDD1677  [4]
 LDCM0478  CL84 HEK-293T C63(0.95)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C63(0.99)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C63(0.91)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C63(0.89)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C63(0.93)  LDD1686  [4]
 LDCM0485  CL90 HEK-293T C63(0.81)  LDD1688  [4]
 LDCM0487  CL92 HEK-293T C63(1.06)  LDD1690  [4]
 LDCM0491  CL96 HEK-293T C63(0.90)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C63(0.86)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C63(0.96)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C63(0.82)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C63(1.04)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C63(0.86)  LDD1631  [4]
 LDCM0022  KB02 22RV1 C370(1.43)  LDD2243  [3]
 LDCM0023  KB03 22RV1 C370(1.65)  LDD2660  [3]
 LDCM0024  KB05 MOLM-13 C32(1.76); C370(1.59)  LDD3333  [3]
 LDCM0112  W16 Hep-G2 C32(0.60)  LDD0239  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A) Cyclic nucleotide phosphodiesterase family O76083
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402