Details of the Target

General Information of Target

Target ID LDTP15695
Target Name Transmembrane protein 186 (TMEM186)
Gene Name TMEM186
Gene ID 25880
Synonyms
C16orf51; Transmembrane protein 186
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGNCSWEAHPGNRNKMCPGLSEAPELYSRGFLTIEQIAMLPPPAVMNYIFLLLCLCGLV
GNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCR
VLGLCMFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNY
FCVFLGRGAPGAACRHMDIFLGILLFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHV
ILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQ
RLWEPLRVVFQRALRDGAELGEAGGSTPNTVTMEMQCPPGNAS
Target Bioclass
Other
Family
TMEM186 family
Subcellular location
Mitochondrion inner membrane
Function As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I.
Uniprot ID
Q96B77
Ensemble ID
ENST00000333050.7
HGNC ID
HGNC:24530

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C156(1.01)  LDD1508  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C156(1.01)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C156(0.95)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C156(0.93)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C156(1.09)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C156(0.93)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C156(0.99)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C156(0.98)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C156(1.07)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C156(0.98)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C156(0.98)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C156(0.98)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C156(1.01)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C156(1.02)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C156(1.01)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C156(0.96)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C156(0.84)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C156(1.03)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C156(1.04)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C156(0.96)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C156(0.95)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C156(1.02)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C156(0.98)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C156(0.95)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C156(0.98)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C156(0.98)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C156(0.94)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C156(1.04)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C156(1.04)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C156(1.12)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C156(0.94)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C156(0.98)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C156(1.00)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C156(0.94)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C156(1.00)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C156(0.96)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C156(1.00)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C156(0.98)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C156(0.99)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C156(0.99)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C156(1.01)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C156(1.01)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C156(1.08)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C156(1.01)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C156(1.08)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C156(0.90)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C156(1.00)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C156(1.06)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C156(1.06)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C156(1.63)  LDD1572  [1]
 LDCM0379  CL11 HEK-293T C156(1.09)  LDD1583  [1]
 LDCM0390  CL12 HEK-293T C156(1.29)  LDD1594  [1]
 LDCM0405  CL18 HEK-293T C156(1.05)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C156(1.13)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C156(1.28)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C156(1.14)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C156(1.21)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C156(1.27)  LDD1616  [1]
 LDCM0419  CL30 HEK-293T C156(1.03)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C156(1.08)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C156(1.47)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C156(1.31)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C156(1.13)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C156(1.37)  LDD1629  [1]
 LDCM0432  CL42 HEK-293T C156(0.99)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C156(1.09)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C156(1.23)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C156(1.27)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C156(1.11)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C156(1.22)  LDD1642  [1]
 LDCM0445  CL54 HEK-293T C156(1.16)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C156(1.09)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C156(1.19)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C156(1.32)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C156(1.20)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C156(1.22)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C156(1.31)  LDD1655  [1]
 LDCM0458  CL66 HEK-293T C156(1.10)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C156(1.15)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C156(1.22)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C156(1.20)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C156(1.29)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C156(1.29)  LDD1668  [1]
 LDCM0471  CL78 HEK-293T C156(1.08)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C156(1.28)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C156(1.09)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C156(1.20)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C156(1.07)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C156(1.14)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C156(1.32)  LDD1681  [1]
 LDCM0484  CL9 HEK-293T C156(1.25)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C156(1.22)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C156(1.06)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C156(1.22)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C156(1.14)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C156(1.20)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C156(1.24)  LDD1694  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019