Details of the Target

General Information of Target

Target ID LDTP15667
Target Name Coronin-2A (CORO2A)
Gene Name CORO2A
Gene ID 7464
Synonyms
IR10; WDR2; Coronin-2A; IR10; WD repeat-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLS
LLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETT
IGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVS
LRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLF
LVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLW
GHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEK
VEEEGAGEGAGGEAGADKEQNGCLPPPESESKV
Target Bioclass
Other
Family
WD repeat coronin family
Uniprot ID
Q92828
Ensemble ID
ENST00000343933.9
HGNC ID
HGNC:2255

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C335(1.23); C474(1.17)  LDD0080  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C25(0.00); C101(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
NAIA_5
 Probe Info  		C25(0.00); C335(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C335(1.25)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C335(1.18)  LDD0543  [1]
 LDCM0237  AC12 HCT 116 C335(1.24)  LDD0554  [1]
 LDCM0259  AC14 HCT 116 C335(1.26)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C335(1.47)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C335(0.88)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C335(1.37)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C335(0.96)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C335(0.96)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C335(0.94)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C335(0.94)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C335(0.87)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C335(0.81)  LDD0601  [1]
 LDCM0296  AC35 HCT 116 C335(0.68)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C335(1.23)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C335(0.98)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C335(1.17)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C335(1.10)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C335(1.10)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C335(1.32)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C335(1.11)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C335(1.59)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C335(0.81)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C335(0.66)  LDD0624  [1]
 LDCM0320  AC57 HCT 116 C335(1.28)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C335(0.93)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C335(1.12)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C335(0.86)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C335(0.99)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C335(1.44)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C335(1.02)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C335(0.90)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C335(0.88)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C335(1.22)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C335(1.26)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C335(1.04)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C335(1.08)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C335(0.99)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C335(1.28)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C335(1.03)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C335(1.20)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C335(1.03)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C335(0.88)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C335(1.32)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C335(0.89)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C335(1.10)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C335(0.99)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C335(0.92)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C335(1.05)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C335(1.15)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C335(1.10)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C335(0.98)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C335(1.17)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C335(0.84)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C335(1.07)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C335(1.33)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C335(1.01)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C335(1.33)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C335(0.91)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C335(1.04)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C335(0.95)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C335(0.98)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C335(0.81)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C335(1.12)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C335(1.23)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C335(0.95)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C335(0.92)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C335(0.95)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C335(1.13)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C335(1.04)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C335(1.08)  LDD0592  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0632  CL-Sc Hep-G2 C335(0.71)  LDD2227  [4]
 LDCM0370  CL101 HCT 116 C335(1.45)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C335(1.21)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C335(0.99)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C335(0.82)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C335(0.97)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C335(1.16)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C335(1.11)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C335(1.06)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C335(0.97)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C335(0.98)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C335(0.94)  LDD0698  [1]
 LDCM0387  CL117 HCT 116 C335(1.15)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C335(1.11)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C335(1.34)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C335(1.19)  LDD0708  [1]
 LDCM0396  CL125 HCT 116 C335(1.36)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C335(1.34)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C335(1.29)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C335(1.64)  LDD0716  [1]
 LDCM0436  CL46 HCT 116 C335(0.78)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C335(1.04)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C335(0.96)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C335(0.95)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C335(0.83)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C335(0.92)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C335(0.88)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C335(0.79)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C335(0.78)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C335(0.88)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C335(1.07)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C335(0.81)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C335(0.97)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C335(1.14)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C335(0.89)  LDD0769  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HCT 116 C335(1.23); C474(1.17)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C335(1.48); C474(1.37)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C335(1.20); C474(1.07)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frataxin, mitochondrial (FXN) Frataxin family Q16595
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxysterols receptor LXR-beta (NR1H2) Nuclear hormone receptor family P55055
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264