Details of the Target

General Information of Target

Target ID LDTP15474
Target Name Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4)
Gene Name L3MBTL4
Gene ID 91133
Synonyms
Lethal(3)malignant brain tumor-like protein 4; H-l(3)mbt-like protein 4; L(3)mbt-like protein 4; L3mbt-like 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWPQPHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPET
TTSEGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYY
SQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE
LQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESE
KSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE
RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQ
EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW
EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM
WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR
EQEDVETGGEAAGAGEADVGAGGEDAGSGAEDVGPGGEDVGAGREAAGEGGENAGAEEDV
AAGGEDAGGEEDAGAGEEDMGPGGEDARGGEDAGAGEEDAGGGGDDAGAGGEDAGAGRED
AGAGGEDVGAGREDAGAGGEDVGAGGEDVGAGRRRCGSSRGCRNRRRSCGNTRRCRSRRS
GAEDVGPEGEDVGAGREAAGEGGENAGAEDVAAGGEDAGEEEDAGGEDAGAAREDAGAGG
DDVGAGREDAGAGGEDVGAGGEDAGAGGEDAGAGGEDAGPGGEDAGAGGEDAGPGGEDAG
AGGEDAGPGGEDVGPGGEDVGAGGEDVGAGGDAREGGEDTRSEREDAGEAARARGAVLRA
LPPSLQSSL
Target Bioclass
Other
Subcellular location
Nucleus
Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility.
Uniprot ID
Q8NA19
Ensemble ID
ENST00000400104.7
HGNC ID
HGNC:26677
ChEMBL ID
CHEMBL1287624

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C379(0.78); C384(0.78)  LDD1125  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0246  AC128 PaTu 8988t C379(0.78); C384(0.78)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C379(0.72); C384(0.72)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C379(0.74); C384(0.74)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C379(0.86); C384(0.86)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C379(0.70); C384(0.70)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C379(0.88); C384(0.88)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C379(0.81); C384(0.81)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C379(1.03); C384(1.03)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C379(1.00); C384(1.00)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C379(0.81); C384(0.81)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C379(0.86); C384(0.86)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C379(0.90); C384(0.90)  LDD1137  [1]
 LDCM0260  AC140 PaTu 8988t C379(0.79); C384(0.79)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C379(0.74); C384(0.74)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C379(1.02); C384(1.02)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C379(1.00); C384(1.00)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C379(1.14); C384(1.14)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C379(0.94); C384(0.94)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C379(0.98); C384(0.98)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C379(0.79); C384(0.79)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C379(0.97); C384(0.97)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C379(1.14); C384(1.14)  LDD1148  [1]
 LDCM0271  AC150 PaTu 8988t C379(0.76); C384(0.76)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C379(0.97); C384(0.97)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C379(1.03); C384(1.03)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C379(1.00); C384(1.00)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C379(0.84); C384(0.84)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C379(0.90); C384(0.90)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C379(1.06); C384(1.06)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C379(1.29); C384(1.29)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C379(1.03); C384(1.03)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C379(0.65); C384(0.65)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C379(1.11); C384(1.11)  LDD1157  [1]
 LDCM0280  AC20 PaTu 8988t C379(0.69); C384(0.69)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C379(1.01); C384(1.01)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C379(0.67); C384(0.67)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C379(0.62); C384(0.62)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C379(0.69); C384(0.69)  LDD1163  [1]
 LDCM0332  AC68 PaTu 8988t C379(1.27); C384(1.27)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C379(0.86); C384(0.86)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C379(1.16); C384(1.16)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C379(1.71); C384(1.71)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C379(1.31); C384(1.31)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C379(1.43); C384(1.43)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C379(1.30); C384(1.30)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C379(0.83); C384(0.83)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C379(1.27); C384(1.27)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C379(2.01); C384(2.01)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C379(1.50); C384(1.50)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C379(1.60); C384(1.60)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C379(1.23); C384(1.23)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C379(1.47); C384(1.47)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C379(1.48); C384(1.48)  LDD1227  [1]
 LDCM0374  CL105 PaTu 8988t C379(0.86); C384(0.86)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C379(0.86); C384(0.86)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C379(1.10); C384(1.10)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C379(0.63); C384(0.63)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C379(0.70); C384(0.70)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C379(0.92); C384(0.92)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C379(0.77); C384(0.77)  LDD1260  [1]
 LDCM0403  CL16 PaTu 8988t C379(0.74); C384(0.74)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C379(0.63); C384(0.63)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C379(0.65); C384(0.65)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C379(0.60); C384(0.60)  LDD1285  [1]
 LDCM0408  CL20 PaTu 8988t C379(0.93); C384(0.93)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C379(1.17); C384(1.17)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C379(0.63); C384(0.63)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C379(0.69); C384(0.69)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C379(0.65); C384(0.65)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C379(0.60); C384(0.60)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C379(0.86); C384(0.86)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C379(0.68); C384(0.68)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C379(1.00); C384(1.00)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C379(0.90); C384(0.90)  LDD1296  [1]
 LDCM0419  CL30 PaTu 8988t C379(0.71); C384(0.71)  LDD1298  [1]
 LDCM0420  CL31 PaTu 8988t C379(0.84); C384(0.84)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C379(0.63); C384(0.63)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C379(0.59); C384(0.59)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C379(0.73); C384(0.73)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C379(0.66); C384(0.66)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C379(0.81); C384(0.81)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C379(0.61); C384(0.61)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C379(0.77); C384(0.77)  LDD1307  [1]
 LDCM0430  CL40 PaTu 8988t C379(0.64); C384(0.64)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C379(0.69); C384(0.69)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C379(0.72); C384(0.72)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C379(0.85); C384(0.85)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C379(0.62); C384(0.62)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C379(0.68); C384(0.68)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C379(0.92); C384(0.92)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C379(0.97); C384(0.97)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C379(0.81); C384(0.81)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C379(0.67); C384(0.67)  LDD1318  [1]
 LDCM0441  CL50 PaTu 8988t C379(0.64); C384(0.64)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C379(0.77); C384(0.77)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C379(0.68); C384(0.68)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C379(0.75); C384(0.75)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C379(1.40); C384(1.40)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C379(1.19); C384(1.19)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C379(0.89); C384(0.89)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C379(1.05); C384(1.05)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C379(0.65); C384(0.65)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C379(1.00); C384(1.00)  LDD1329  [1]
 LDCM0452  CL60 PaTu 8988t C379(0.91); C384(0.91)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C379(1.15); C384(1.15)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C379(1.33); C384(1.33)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C379(1.54); C384(1.54)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C379(0.99); C384(0.99)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C379(0.90); C384(0.90)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C379(1.06); C384(1.06)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C379(1.39); C384(1.39)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C379(1.29); C384(1.29)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C379(1.32); C384(1.32)  LDD1340  [1]
 LDCM0463  CL70 PaTu 8988t C379(1.09); C384(1.09)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C379(1.27); C384(1.27)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C379(1.67); C384(1.67)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C379(1.37); C384(1.37)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C379(1.55); C384(1.55)  LDD1346  [1]
 LDCM0468  Fragment33 PaTu 8988t C379(1.12); C384(1.12)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C379(0.63); C384(0.63)  LDD1306  [1]
 LDCM0022  KB02 MGG123 C858(2.71)  LDD2469  [2]
 LDCM0023  KB03 MGG123 C858(2.97)  LDD2886  [2]
 LDCM0024  KB05 MGG123 C858(3.09)  LDD3303  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031
Ninein-like protein (NINL) . Q9Y2I6

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840