Details of the Target

General Information of Target

Target ID LDTP15360
Target Name Transcription elongation factor A protein-like 8 (TCEAL8)
Gene Name TCEAL8
Gene ID 90843
Synonyms
Transcription elongation factor A protein-like 8; TCEA-like protein 8; Transcription elongation factor S-II protein-like 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEVGRTGISYPGALLPQGFWAAVEVWLERPQVANKRLCGARLEARWSAALPCAEARGPG
TSAGSEQKERGPGPGQGSPGGGPGPRSLSGPEQGTACCELEEAQGQCQQEEAQREAASVP
LRDSGHPGHAEGREGDFPAADLDSLWEDFSQSLARGNSELLAFLTSSGAGSQPEAQRELD
VVLRTVIPKTSPHCPLTTPRREIVVQDVLNGTITFLPLEEDDEGNLKVKMSNVYQIQLSH
SKEEWFISVLIFCPERWHSDGIVYPKPTWLGEELLAKLAKWSVENKKSDFKSTLSLISIM
KYSKAYQELKEKYKEMVKVWPEVTDPEKFVYEDVAIAAYLLILWEEERAERRLTARQSFV
DLGCGNGLLVHILSSEGHPGRGIDVRRRKIWDMYGPQTQLEEDAITPNDKTLFPDVDWLI
GNHSDELTPWIPVIAARSSYNCRFFVLPCCFFDFIGRYSRRQSKKTQYREYLDFIKEVGF
TCGFHVDEDCLRIPSTKRVCLVGKSRTYPSSREASVDEKRTQYIKSRRGCPVSPPGWELS
PSPRWVAAGSAGHCDGQQALDARVGCVTRAWAAEHGAGPQAEGPWLPGFHPREKAERVRN
CAALPRDFIDQVVLQVANLLLGGKQLNTRSSRNGSLKTWNGGESLSLAEVANELDTETLR
RLKRECGGLQTLLRNSHQVFQVVNGRVHIRDWREETLWKTKQPEAKQRLLSEACKTRLCW
FFMHHPDGCALSTDCCPFAHGPAELRPPRTTPRKKIS
Target Bioclass
Other
Family
TFS-II family, TFA subfamily
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8IYN2
Ensemble ID
ENST00000360000.8
HGNC ID
HGNC:28683

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C5(1.79)  LDD3401  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]
Phosphinate-6
 Probe Info  		C5(0.00); C114(0.00)  LDD0018  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C114(1.09)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C5(1.00)  LDD1510  [5]
 LDCM0270  AC15 HEK-293T C5(1.10)  LDD1513  [5]
 LDCM0278  AC19 HEK-293T C114(1.00)  LDD1517  [5]
 LDCM0280  AC20 HEK-293T C5(0.99)  LDD1519  [5]
 LDCM0283  AC23 HEK-293T C5(1.14)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C5(1.21)  LDD1523  [5]
 LDCM0287  AC27 HEK-293T C114(1.17)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C5(0.96)  LDD1527  [5]
 LDCM0290  AC3 HEK-293T C114(1.05)  LDD1529  [5]
 LDCM0292  AC31 HEK-293T C5(0.82)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C5(1.20)  LDD1532  [5]
 LDCM0296  AC35 HEK-293T C114(1.09)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C5(1.11)  LDD1536  [5]
 LDCM0300  AC39 HEK-293T C5(1.13)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C5(0.94)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C5(1.00)  LDD1541  [5]
 LDCM0305  AC43 HEK-293T C114(1.23)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C5(1.09)  LDD1545  [5]
 LDCM0309  AC47 HEK-293T C5(1.02)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C5(1.04)  LDD1549  [5]
 LDCM0314  AC51 HEK-293T C114(1.04)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C5(1.10)  LDD1554  [5]
 LDCM0318  AC55 HEK-293T C5(1.31)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C5(1.21)  LDD1558  [5]
 LDCM0322  AC59 HEK-293T C114(1.13)  LDD1561  [5]
 LDCM0324  AC60 HEK-293T C5(1.00)  LDD1563  [5]
 LDCM0327  AC63 HEK-293T C5(1.35)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C5(1.05)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C5(0.92)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C5(0.92)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C5(1.16)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C5(1.00); C114(1.01)  LDD1571  [5]
 LDCM0369  CL100 HEK-293T C5(0.97)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C5(0.93); C114(1.11)  LDD1574  [5]
 LDCM0373  CL104 HEK-293T C5(1.01)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C5(1.21); C114(1.06)  LDD1578  [5]
 LDCM0377  CL108 HEK-293T C5(1.08)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C5(0.79); C114(0.98)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C5(0.82)  LDD1583  [5]
 LDCM0382  CL112 HEK-293T C5(1.02)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C5(1.18); C114(1.15)  LDD1587  [5]
 LDCM0386  CL116 HEK-293T C5(1.33)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C5(1.08); C114(1.02)  LDD1591  [5]
 LDCM0390  CL12 HEK-293T C5(1.00)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C5(1.07)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C5(1.04); C114(1.14)  LDD1596  [5]
 LDCM0395  CL124 HEK-293T C5(1.03)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C5(1.01); C114(1.14)  LDD1600  [5]
 LDCM0399  CL128 HEK-293T C5(1.14)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C5(1.10); C114(1.11)  LDD1604  [5]
 LDCM0403  CL16 HEK-293T C5(1.08)  LDD1607  [5]
 LDCM0406  CL19 HEK-293T C114(1.27)  LDD1610  [5]
 LDCM0408  CL20 HEK-293T C5(1.00)  LDD1612  [5]
 LDCM0411  CL23 HEK-293T C5(1.11)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C5(1.25)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C5(0.97); C114(1.05)  LDD1617  [5]
 LDCM0416  CL28 HEK-293T C5(1.24)  LDD1620  [5]
 LDCM0420  CL31 HEK-293T C114(1.13)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C5(1.01)  LDD1625  [5]
 LDCM0424  CL35 HEK-293T C5(1.20)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C5(1.35)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C5(1.19); C114(1.08)  LDD1630  [5]
 LDCM0429  CL4 HEK-293T C5(1.04)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C5(1.42)  LDD1634  [5]
 LDCM0433  CL43 HEK-293T C114(1.35)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C5(1.07)  LDD1638  [5]
 LDCM0437  CL47 HEK-293T C5(1.02)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C5(1.72)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C5(1.03); C114(1.13)  LDD1643  [5]
 LDCM0443  CL52 HEK-293T C5(1.27)  LDD1646  [5]
 LDCM0446  CL55 HEK-293T C114(1.33)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C5(1.07)  LDD1650  [5]
 LDCM0450  CL59 HEK-293T C5(0.88)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C5(1.24)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C5(1.16); C114(1.11)  LDD1656  [5]
 LDCM0456  CL64 HEK-293T C5(0.99)  LDD1659  [5]
 LDCM0459  CL67 HEK-293T C114(1.30)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C5(1.03)  LDD1663  [5]
 LDCM0462  CL7 HEK-293T C114(1.38)  LDD1665  [5]
 LDCM0464  CL71 HEK-293T C5(1.15)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C5(1.50)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C5(1.00); C114(1.14)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C5(1.29)  LDD1672  [5]
 LDCM0472  CL79 HEK-293T C114(1.12)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C5(0.76)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C5(0.93)  LDD1677  [5]
 LDCM0477  CL83 HEK-293T C5(0.97)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C5(0.92)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C5(1.16); C114(1.11)  LDD1682  [5]
 LDCM0482  CL88 HEK-293T C5(1.35)  LDD1685  [5]
 LDCM0486  CL91 HEK-293T C114(1.29)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C5(1.20)  LDD1690  [5]
 LDCM0490  CL95 HEK-293T C5(0.95)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C5(1.08)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C5(1.02); C114(1.13)  LDD1695  [5]
 LDCM0022  KB02 HEK-293T C5(0.90)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C5(0.93)  LDD1497  [5]
 LDCM0024  KB05 RD C5(1.79)  LDD3401  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine--tRNA ligase, cytoplasmic (YARS1) Class-I aminoacyl-tRNA synthetase family P54577
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
COMM domain-containing protein 1 (COMMD1) . Q8N668
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402