Details of the Target

General Information of Target

Target ID LDTP15037
Target Name Zinc finger protein 691 (ZNF691)
Gene Name ZNF691
Gene ID 51058
Synonyms
Zinc finger protein 691
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAE
HREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALG
ADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPA
GLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERG
GDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQ
DKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEG
DVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRP
SIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNAC
S
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q5VV52
Ensemble ID
ENST00000372502.5
HGNC ID
HGNC:28028

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C176(2.03)  LDD3343  [1]
IA-alkyne
 Probe Info  		C230, C232(20.00)  LDD1707  [2]
Lodoacetamide azide
 Probe Info  		C229(0.00); C230(0.00); C232(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
HHS-465
 Probe Info  		K141(0.00); K144(0.00); Y143(0.00)  LDD2240  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C230(1.00)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C230(0.79)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C230(1.11)  LDD1513  [7]
 LDCM0280  AC20 HEK-293T C230(1.11)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C230(0.96)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C230(0.91)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C230(1.05)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C230(0.91)  LDD1523  [7]
 LDCM0288  AC28 HEK-293T C230(1.01)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C230(1.17)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C230(0.75)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C230(1.04)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C230(0.99)  LDD1532  [7]
 LDCM0297  AC36 HEK-293T C230(0.90)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C230(0.98)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C230(0.81)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C230(1.06)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C230(1.32)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C230(0.97)  LDD1541  [7]
 LDCM0306  AC44 HEK-293T C230(0.93)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C230(1.08)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C230(1.16)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C230(1.01)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C230(1.18)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C230(1.19)  LDD1551  [7]
 LDCM0315  AC52 HEK-293T C230(0.98)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C230(1.08)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C230(0.67)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C230(1.16)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C230(1.21)  LDD1558  [7]
 LDCM0323  AC6 HEK-293T C230(0.86)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C230(1.32)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C230(1.19)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C230(0.78)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C230(1.13)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C230(1.08)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C230(1.08)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C230(0.92)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C230(1.21)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C230(0.99)  LDD1514  [7]
 LDCM0368  CL10 HEK-293T C230(0.86)  LDD1572  [7]
 LDCM0372  CL103 HEK-293T C230(0.93)  LDD1576  [7]
 LDCM0376  CL107 HEK-293T C230(0.87)  LDD1580  [7]
 LDCM0379  CL11 HEK-293T C230(1.18)  LDD1583  [7]
 LDCM0381  CL111 HEK-293T C230(1.69)  LDD1585  [7]
 LDCM0385  CL115 HEK-293T C230(1.19)  LDD1589  [7]
 LDCM0389  CL119 HEK-293T C230(1.11)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C230(1.15)  LDD1594  [7]
 LDCM0394  CL123 HEK-293T C230(1.39)  LDD1598  [7]
 LDCM0398  CL127 HEK-293T C230(0.94)  LDD1602  [7]
 LDCM0402  CL15 HEK-293T C230(1.06)  LDD1606  [7]
 LDCM0408  CL20 HEK-293T C230(0.97)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C230(1.42)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C230(1.18)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C230(1.18)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C230(1.38)  LDD1616  [7]
 LDCM0415  CL27 HEK-293T C230(1.14)  LDD1619  [7]
 LDCM0418  CL3 HEK-293T C230(1.38)  LDD1622  [7]
 LDCM0421  CL32 HEK-293T C230(1.54)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C230(1.14)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C230(1.01)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C230(1.08)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C230(0.92)  LDD1629  [7]
 LDCM0428  CL39 HEK-293T C230(1.28)  LDD1632  [7]
 LDCM0434  CL44 HEK-293T C230(1.24)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C230(1.36)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C230(0.99)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C230(1.03)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C230(1.24)  LDD1642  [7]
 LDCM0447  CL56 HEK-293T C230(1.02)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C230(1.57)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C230(0.68)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C230(1.18)  LDD1653  [7]
 LDCM0452  CL60 HEK-293T C230(1.05)  LDD1655  [7]
 LDCM0455  CL63 HEK-293T C230(1.05)  LDD1658  [7]
 LDCM0460  CL68 HEK-293T C230(0.97)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C230(1.06)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C230(0.89)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C230(1.25)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C230(1.50)  LDD1668  [7]
 LDCM0473  CL8 HEK-293T C230(1.01)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C230(1.09)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C230(1.13)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C230(0.85)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C230(1.09)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C230(1.32)  LDD1681  [7]
 LDCM0481  CL87 HEK-293T C230(2.14)  LDD1684  [7]
 LDCM0484  CL9 HEK-293T C230(1.01)  LDD1687  [7]
 LDCM0487  CL92 HEK-293T C230(1.01)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C230(1.18)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C230(1.06)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C230(1.10)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C230(1.24)  LDD1694  [7]
 LDCM0494  CL99 HEK-293T C230(1.03)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C230(0.98)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C230(1.60)  LDD1671  [7]
 LDCM0022  KB02 HEK-293T C230(0.83)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C230(0.99)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1299 C176(2.03)  LDD3343  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402