Details of the Target

General Information of Target

Target ID LDTP15031
Target Name Tetratricopeptide repeat protein 39B (TTC39B)
Gene Name TTC39B
Gene ID 158219
Synonyms
C9orf52; Tetratricopeptide repeat protein 39B; TPR repeat protein 39B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTPGKHSGASARAANGGAWGYRDFRGGQKKGWCTTPQLVATMPVSPAGSHKQQNFGLNNA
TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN
GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL
GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL
TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN
KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG
STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL
AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC
DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWPERIYQSPYGVT
AVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGT
TGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQ
APGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVF
LSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHIST
LDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLETGRGDIMDTLL
GSKSNQSA
Target Bioclass
Other
Family
TTC39 family
Function Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).
Uniprot ID
Q5VTQ0
Ensemble ID
ENST00000507285.5
HGNC ID
HGNC:23704

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C203(0.25)  LDD2228  [1]
IA-alkyne
 Probe Info  		C277(1.64)  LDD2182  [2]
DBIA
 Probe Info  		C139(1.05); C203(1.02)  LDD1509  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C139(1.05); C203(1.02)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C139(1.00)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C139(1.21)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C139(0.96)  LDD1513  [3]
 LDCM0278  AC19 HEK-293T C139(1.03); C203(1.19)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C139(0.89)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C139(1.10)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C139(0.99)  LDD1522  [3]
 LDCM0287  AC27 HEK-293T C139(1.12); C203(1.02)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C139(0.94)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C139(1.12); C203(0.83)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C139(0.87)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C139(1.02)  LDD1531  [3]
 LDCM0296  AC35 HEK-293T C139(1.02); C203(0.99)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C139(1.08)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C139(1.13)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C139(1.23)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C139(0.86)  LDD1540  [3]
 LDCM0305  AC43 HEK-293T C139(1.03); C203(0.99)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C139(1.07)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C139(1.07)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C139(1.05)  LDD1548  [3]
 LDCM0314  AC51 HEK-293T C139(1.11); C203(1.03)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C139(0.93)  LDD1554  [3]
 LDCM0317  AC54 HEK-293T C139(1.16)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C139(1.04)  LDD1557  [3]
 LDCM0322  AC59 HEK-293T C139(1.02); C203(1.21)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C139(1.06)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C139(1.09)  LDD1563  [3]
 LDCM0326  AC62 HEK-293T C139(1.01)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C139(1.18)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C139(1.13)  LDD1568  [3]
 LDCM0367  CL1 HEK-293T C139(0.85)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C139(0.94)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C139(1.23)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C139(0.99)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C139(0.86)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C139(1.10)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C139(0.85)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C139(0.80)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C139(1.09)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C139(0.84)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C139(1.29)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C139(0.91)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C139(0.93)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C139(0.81)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C139(0.76)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C139(1.08)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C139(0.98)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C139(0.98)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C139(0.89)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C139(1.07)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C139(0.81)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C139(0.93)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C139(1.09)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C139(0.70)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C139(1.13)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C139(0.75)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C139(0.75)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C139(1.06)  LDD1607  [3]
 LDCM0406  CL19 HEK-293T C139(1.13); C203(0.98)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C139(0.97)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C139(1.22)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C139(1.26)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C139(0.95)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C139(0.73)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C139(1.04)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C139(0.70)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C139(0.93); C203(1.58)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C139(0.92)  LDD1625  [3]
 LDCM0423  CL34 HEK-293T C139(1.00)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C139(1.29)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C139(1.04)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C139(0.65)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C139(1.01)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C139(1.06)  LDD1634  [3]
 LDCM0433  CL43 HEK-293T C139(1.11); C203(0.91)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C139(0.99)  LDD1638  [3]
 LDCM0436  CL46 HEK-293T C139(1.15)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C139(1.22)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C139(0.73)  LDD1643  [3]
 LDCM0443  CL52 HEK-293T C139(1.01)  LDD1646  [3]
 LDCM0446  CL55 HEK-293T C139(1.12); C203(1.40)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C139(1.02)  LDD1650  [3]
 LDCM0449  CL58 HEK-293T C139(1.22)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C139(1.30)  LDD1653  [3]
 LDCM0453  CL61 HEK-293T C139(0.93)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C139(0.76)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C139(1.44)  LDD1659  [3]
 LDCM0459  CL67 HEK-293T C139(1.00); C203(1.19)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C139(1.01)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C139(1.21); C203(1.19)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C139(1.24)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C139(1.17)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C139(0.89)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C139(0.90)  LDD1672  [3]
 LDCM0472  CL79 HEK-293T C139(1.01); C203(1.17)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C139(1.73)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C139(0.92)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C139(1.07)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C139(0.99)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C139(0.78)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C139(0.82)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C139(0.79)  LDD1685  [3]
 LDCM0486  CL91 HEK-293T C139(1.26); C203(1.10)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C139(0.98)  LDD1690  [3]
 LDCM0489  CL94 HEK-293T C139(1.08)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C139(1.07)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C139(1.13)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C139(0.72)  LDD1697  [3]
 LDCM0634  CY-0357 Hep-G2 C203(0.25)  LDD2228  [1]
 LDCM0495  E2913 HEK-293T C139(0.76)  LDD1698  [3]
 LDCM0625  F8 Ramos C277(0.67)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C277(1.82)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C277(0.47)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C277(1.37)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C277(1.03)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C277(1.69)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C277(1.27)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C277(1.09)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C277(1.46)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C277(1.08)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C277(0.72)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C277(1.32)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C277(1.32)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C277(1.79)  LDD2201  [2]
 LDCM0468  Fragment33 HEK-293T C139(0.85)  LDD1671  [3]
 LDCM0596  Fragment38 Ramos C277(1.02)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C277(0.80)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C277(1.23)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C277(1.36)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C277(1.29)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C277(1.70)  LDD2188  [2]
 LDCM0022  KB02 Ramos C277(1.64)  LDD2182  [2]
 LDCM0023  KB03 Ramos C277(1.06)  LDD2183  [2]
 LDCM0024  KB05 Ramos C277(1.32)  LDD2185  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019